Training Program in Inflammatory Diseases Research
T-PID provides a multidisciplinary background for trainees in inflammatory disorders coupled with intensive laboratory training in a particular research topic. The program provides predoctoral and postdoctoral trainees with a solid academic background in immunology with emphasis on multi disciplinary approaches to study common mechanisms of inflammation.
Faculty research interests encompass three broad research areas including 1) Pathogen induced inflammation; 2) Chronic non-communicable inflammatory disorders; and 3) Therapeutics and preventative strategies.
Figure: Inflammatory Disease and Therapeutics. This figure is included as an outline of the general concepts and organization of the inflammatory process that investigators included in this training grant proposal investigate. Each letter denotes a specific topic we will emphasize and an area where therapeutics have an impact, both in enhancing or suppressing the inflammatory process that can help immunity to diseases or to dampen an over exuberant immune response associated with inflammation. Specific examples include the following: (A and B) Use of immune adjuvants to enhance immunity to vaccines, use of TLR ligands to induce innate immune responses to suppress disease i.e. CpG DNA for infectious diseases, BCG for bladder cancer, blockade of innate immune responses induced by pattern recognition receptor ligands, i.e. sepsis, lupus; (C) Use of inflammatory cytokines to enhance immunity to pathogens, blockade of TNF in autoimmune disease, i.e. rheumatoid arthritis, inflammatory bowel disease; (D) Use of adjuvants to increase costimulatory activity; and (E) T cell suppression in transplants.