Igor Kramnik Ph.D.
Medicine- Pulmonary / NEIDL
Office: 650 Albany St. 6th floor
Research in the Kramnik laboratory is focused on mechanisms of host resistance to virulent M. tuberculosis. Using forward genetic analysis of tuberculosis susceptibility in the mouse model, they have found a unique genetic locus that controls progression of pulmonary TB and formation of necrosis within lung granulomas and identified a candidate gene (Ipr1) by positional cloning. Most of the work in Dr. Kramnik’s laboratory in recent years has focused on the characterization of this locus at molecular, cellular and whole organism levels. They have demonstrated that the Lpr1 protein controls a novel interferon-dependent mechanism of ribosomal stress response in macrophages. They have created a set of congenic mouse strains that represent a first realistic model of human pulmonary tuberculosis in mice, which recapitulates a key element of the disease – formation of well-organized granulomas with necrotic core, in the lungs. This model allows assessing the efficiency of anti-tuberculosis vaccines, drugs and other interventions more accurately. They are currently using this model for the experimental analysis of the biology of tuberculosis granulomas and other lung-specific mechanisms of tuberculosis pathogenesis, as well as for translational research in collaborative studies.