Emergency BU Alert BU Medical Campus OPEN Jan. 28, 2015 Boston University Medical Campus will be open Wednesday, Jan. 28, 2015. BUSM classes will be held as scheduled. Staff should check with their managers regarding work schedules. Medical, PA and GMS students who are assigned to inpatient services or clinics are expected to be present, if possible. Students who are assigned to outpatient services should check with their course director or the policy at the clinical site. GMS classes are canceled. Staff should check with their manager regarding their work schedules. The Henry M. Goldman School of Dental Medicine will follow normal school hours. All Patient Treatment Centers will be open for patient care and all classes will be held as scheduled. BU School of Public Health classes are canceled; SPH non-essential staff may telecommute. Employees who are part of the BUMC parking program should park in your assigned lot or garage. The Boston parking ban is still in effect. For updated information, please call the weather/emergency hotline at 617-638-6886 or visit the BU Emergency Communications website at http://www.bu.edu/ehs/comm/

Igor Kramnik Ph.D.

Medicine- Pulmonary / NEIDL

Office: 650 Albany St. 6th floor

Phone: 617-414-0344

Email: ikramnik@bu.edu


Research in the Kramnik laboratory is focused on mechanisms of host resistance to virulent M. tuberculosis. Using forward genetic analysis of tuberculosis susceptibility in the mouse model, they have found a unique genetic locus that controls progression of pulmonary TB and formation of necrosis within lung granulomas and identified a candidate gene (Ipr1) by positional cloning. Most of the work in Dr. Kramnik’s laboratory in recent years has focused on the characterization of this locus at molecular, cellular and whole organism levels. They have demonstrated that the Lpr1 protein controls a novel interferon-dependent mechanism of ribosomal stress response in macrophages. They have created a set of congenic mouse strains that represent a first realistic model of human pulmonary tuberculosis in mice, which recapitulates a key element of the disease – formation of well-organized granulomas with necrotic core, in the lungs. This model allows assessing the efficiency of anti-tuberculosis vaccines, drugs and other interventions more accurately. They are currently using this model for the experimental analysis of the biology of tuberculosis granulomas and other lung-specific mechanisms of tuberculosis pathogenesis, as well as for translational research in collaborative studies.

Affiliated Websites:

BUSM Department of Microbiology Webpage