TPID students from all Departments will be required to take the core courses (1-4) below. In addition, Molecular Medicine Students will be required to take part in (5); Biomedical Engineering in (6); Microbiology in (7); and Pathology students in (8). Required courses for Departments not listed above will be developed with the Graduate Director of the respective Departments. Representative course syllabi for the courses listed below are provided in the following websites: (www.bumc.bu.edu/gms and www.bu.edu/bme/graduate/courses).
(1) Foundations in Biomedical Sciences (4 modules, 2 credits per module)
(a) I: Protein Structure, Catalysis and Interaction (GMS FC701 2 credits – www.bumc.bu.edu/gms) This first module will provide students with a quantitative understanding of protein structure, function, posttranslational modification and the turnover of proteins in the cell. In addition, students will gain facility with thermodynamics, catalysis, kinetics and binding equilibriums as they apply to proteins and also to other molecules in biological systems (e.g. nucleic acids, lipids, vitamins, etc.).
(b) II: Structure and Function of the Genome (GMS FC702, 2 credits – www.bumc.bu.edu/gms) The second module will focus on the mechanisms of biological processes that influence the inheritance, regulation, and utilization of genes. Genetic and genomic, molecular, cell biological, and biochemical experimental approaches to understanding these processes will be explored. In addition, we will discuss the possibilities of utilizing these technologies in medical therapies.
(c) III: Architecture & Dynamics of the Cell (GMS FC703, 2 credits – www.bumc.bu.edu/gms) The third module will focus on the movement of proteins and membranes with the cell, the secretory process, the cytoskeletal framework of the cell and the resulting cell-cell interaction and communication with the matrix. Molecular, cell biological, and biochemical experimental approaches to understanding these processes will be explored. In addition, we will discuss the possibilities of utilizing these technologies in medical treatments.
(d) IV: Mechanisms of Cell Communication (GMS FC704, 2 credits – www.bumc.bu.edu/gms) The fourth module will focus on the mechanisms of cell communication. This module will begin by discussing overarching concepts before examining the specific types of molecules that initiate and transduce signals. Examples of cell signaling and subsequent cellular responses will be considered in different contexts to provide a framework on which future learning can be applied. As the module progresses, the complexity of the systems explored will increase from individual cells to multicellular environments such as tissues, organs, and organisms.
(2) Comprehensive Immunology (GMS MI 713, 4 credits- www.bumc.bu.edu/gms): This course is a comprehensive introduction to immunologic principals and applications. Emphasis is placed on analysis and interpretation of data from the primary literature.
(3) Immunological Basis of Disease (GMS MI 715; 4 credits- www.bumc.bu.edu/gms): This course is an in depth analysis of historically significant and contemporary topics in cellular and molecular immunology with a focus on immunologically based diseases. Emphasis is placed on the in-class discussion of research papers.
(4) Inflammatory Diseases and Therapeutics (GMS MM 2 credits). This course examines modalities that have been used to alter inflammation to either enhance the process to aid in protection from pathology, or to minimize inflammatory responses to treat sequelae associated with an over-exuberant immune response. This course examines common mechanisms of inflammatory processes with regard to disease induction, and to interventions to prevent or alleviate these inflammatory disorders.
(5) Genetics and Epidemiology of Human Diseases (GMS MM701, 4 credits- www.bumc.bu.edu/gms). This course covers fundamentals of the genetics of common human diseases and discusses examples of epidemiological approaches to study human disease.
(6) Molecular Bioengineering (ENG BE505, 4 credits- www.bu.edu/bme/graduate/courses). This course is an engineering science based introduction to the building blocks of living cells and materials for biotechnology. Throughout the course, detailed structural and energetic properties of molecules are emphasized.
(7) Concepts in Microbiology (GMS MI 700, 4 credits- www.bumc.bu.edu/gms): This course provides a fundamental understanding of the world of microbes and the concepts and mechanisms involved as microbes adapt in changing environments.
(8) Basic and Experimental Pathology (GMS PA 700, 6 credits- www.bumc.bu.edu/gms). This course provides an overview of the basic principles of Pathology through a lecture format. Topics include acute and chronic inflammation, pathology of auto-immunity, cancer immunology, and wound healing.