Emergency BU Alert BU Medical Campus OPEN Jan. 28, 2015 Boston University Medical Campus will be open Wednesday, Jan. 28, 2015. BUSM classes will be held as scheduled. Staff should check with their managers regarding work schedules. Medical, PA and GMS students who are assigned to inpatient services or clinics are expected to be present, if possible. Students who are assigned to outpatient services should check with their course director or the policy at the clinical site. GMS classes are canceled. Staff should check with their manager regarding their work schedules. The Henry M. Goldman School of Dental Medicine will follow normal school hours. All Patient Treatment Centers will be open for patient care and all classes will be held as scheduled. BU School of Public Health classes are canceled; SPH non-essential staff may telecommute. Employees who are part of the BUMC parking program should park in your assigned lot or garage. The Boston parking ban is still in effect. For updated information, please call the weather/emergency hotline at 617-638-6886 or visit the BU Emergency Communications website at http://www.bu.edu/ehs/comm/

Signaling

It is now a fundamental principle that diffusible molecules act intracellularly to translate an external signal into appropriate cellular responses. Second messengers like calcium, inositol polyphosphates and cyclic nucleotides, are such molecules. Calcium in particular can mediate cellular reactions as diverse as muscle contraction, neurotransmitter release, phototransduction and neuron excitability. One important question is how an elevation of intracellular calcium mediates so many processes. The answer lies in the versatility of the calcium signaling system. Assessing the role of calcium in biological systems involves powerful biophysical techniques such as electrophysiology and calcium sensitive dyes; other techniques involve measurement of calcium using calcium-sensitive microelectrodes. An example is shown below for Drosophila.

Set up for measurement of extracellular voltage and calcium by means of calcium-sensitive microelectrodes in the retina of Drosophila

Anoxia activates light-sensitive channels as monitored by calcium influx: extracellular voltage change (ERG, top trace) and measurement with calcium-sensitive microelectrode (ECa, bottom trace) in response to light (LM, light monitor) and anoxia (N2).

The following links provide more information about specific projects in several laboratories of the department.

Directory|BUMC
June 16, 2010
Primary teaching affiliate
of BU School of Medicine