Jeffery R. Moore, Ph.D. – Publications

Dr. Jeffrey R. Moore
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Farman G. P., Muthu P., Kazmierczak K., Szczesna-Cordary D., Moore J.R. (2014) Impact of Familial Hypertrophic Cardiomyopathy-linked Mutations in the N-Terminus of the RLC on b-Myosin Cross-bridge Mechanics. J. Appl. Physiology. [Epub ahead of print]

Orzechowski M., Moore J.R. Fischer S. Lehman W.L. Farman G. P. (2014) Energy landscapes reveal the myopathic effects of tropomyosin mutations  Arch Biochem Biophys. Dec 15;564:89-99

Guo M., Ehrlicher A.J., Jensen M.H., Renz M., Moore J.R., Goldman R.D., Lippincott-Schwartz J., Mackintosh F.C., Weitz D.A. (2014) Probing the stochastic motor-driven properties of the cytoplasm using force spectrum microscopy. Cell. 158(4):822-832

Huang W, Liang J, Kazmierczak K, Muthu P, Duggal D, Farman GP, Sorensen L, Pozios I, Abraham TP, Moore JR, Borejdo J, Szczesna-Cordary D. (2014) Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice. J Mol Cell Cardiol. 30;74C:318-329. [Epub ahead of print] PMID: 24992035

Jensen M.H., Morris E.J., Gallant C. M., Morgan K.G., Weitz D.A., Moore J.R. (2014) Mechanism of calponin stabilization of crosslinked actin networks  Biophys. J. 106:793-800 PMCID: PMC3944828

Orzechowski M., Moore J.R. Fischer S. Lehman W.L. (2014) Tropomyosin movement on F-actin during muscle activation explained by energy landscapes.  Arch Biochem Biophys. 545:63-68. PMCID: PMC3943668

Muthu P., Liang J., Schmidt W., Moore J.R., Szczesna-Cordary D (2014) In vitro rescue study of a malignant familial hypertrophic cardiomyopathy phenotype by pseudo-phosphorylation of myosin regulatory light chain. Arch Biochem Biophys. 552-553: 29-39 PMCID: PMC4043912..

Saphirstein R. J., Gao Y.Z., Jensen M.H., Gallant C.M., Vetterkind S., Moore J.R., Morgan K.G.(2013) The focal adhesion: a regulated component of aortic stiffness. PLoS One. 23;8(4):e62461. doi: 10.1371/journal.pone.0062461. PMCID: PMC3633884.

Guo M., Ehrlicher A.J., Mahammad S., Fabich H., Jensen M.H., Moore J.R., Fredberg J.J., GoldmanR.D., Weitz D.A. (2013) The role of vimentin intermediate filaments in cortical and cytoplasmic mechanics. Biophys J. 2013 105(7):1562-8. PMCID: PMC3791300.

Szczesna-Cordary D., Morimoto S., Gomes A.V., Moore J.R. (2012) Cardiomyopathies:classification, clinical characterization, and functional phenotypes. Biochem Res Int. 870942. PMCID: PMC3529434.

Jensen M.H., Morris E.J., Huang R., Rebowski G., Dominguez R., Weitz D.A., Moore J.R., Wang C-L. (2012) The conformational state of actin filaments regulates branching by actin-related protein 2/3 (Arp2/3) complex. J Biol Chem. 287(37):31447-53 PMCID: PMC3438974

Moore, J. R., Leinwand, L., Warshaw, D. W. (2012) Understanding Cardiomyopathy Phenotypes Based on the Functional Impact of Mutations in the Myosin Motor. Circulation Res. 20;111:375-85.

Jensen M.H., Watt J., Hodgkinson J., Gallant C., Appel S., El-Mezgueldi M., Angelini T., Morgan K.G., Lehman W., and Moore J.R. (2011) Effects of basic calponin on the flexural mechanics and stability of F-actin Cytoskeleton Cytoskeleton 69(1):49-58.PMCID: PMC3355516.

Moore, J.R., Nirody J., Li X.E., Fischer S., Lehman W. (2011) Structural implications of conserved aspartate residues located in tropomyosin’s coiled-coil core. BioArchitecture 1:250-255.PMCID: PMC3384579.

Collins A., Huang R., Jensen M. H., Moore J.R., Lehman W., Wang Chih-Lueh Albert (2011) Structural studies on maturing actin filaments. BioArchitechture. BioArchitechture. 1:127-33.PMCID: PMC3173961.

Lu X., Kazmierczak K., Jiang X.,  Jones M., Watt J., Helfman D., Moore J.R., Szczesna-Cordary D, Lossos D. (2011) Germinal Center Specific Protein HGAL Directly Interacts with Both Myosin and Actin and Increases the Binding of Myosin to Actin FEBS J. 11:1922-31PMCID: PMC3097272

Lin T., Greenberg M.J., Moore J.R., Ostap E.M. (2011) A hearing loss-associated myo1c mutation(R156W) decreases the myosin duty ratio and force sensitivity. Biochemistry. 50(11):1831-8 PMCID: PMC3059334. Pub Med

Greenberg, M. J., Kazmierczak K., Szczesna-Cordary D., Moore J. R.  (2010) Cardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent    biochemistry. Proc Natl Acad Sci U S A. 107(40):17403-8. PMCID: PMC2951453. Pub Med

Greenberg MJ, Moore JR. (2010) The molecular basis of frictional loads in the in vitro motility assay with applications to the study of the loaded mechanochemistry of molecular motors. Cytoskeleton. 67(5):273-85. Pub Med

Greenberg, M., Mealy, T., Jones, M., Szczesna-Cordary, D.,  Moore, J., (2010) The direct molecular effects of fatigue and myosin regulatory light chain phosphorylation on the actomyosin contractile apparatus. Am J Physiol Regul Integr Comp Physiol 298(4):R989-96.PMCID: PMC2853388. Pub Med

Greenberg, M. and Moore, J. (2010) Actin in action and inaction: The differential effects of hypertrophic and dilated cardiomyopathy actin mutations on thin filament J Mol Cell Cardiol. 48:277-8. Pub Med

Greenberg, M., Watt, J., Mealy, T., Jones, M., Szczesna-Cordary, D., Moore, J., (2009) The Molecular Effects of Skeletal Muscle Myosin Regulatory Light Chain Phosphorylation Am J Physiol Regul Integr Comp Physiol 297(2): 265-74. PMCID: PMC2724231. Pub Med

Pant, K., Watt, J., Greenberg, M., Jones, M., Szczesna-Cordary, D., Moore, J., (2009) Removal of the Cardiac Myosin Regulatory Light Chain Increases Isometric Force Production. FASEB J 23: 3571-80. PMCID: PMC2747675. Pub Med

Greenberg, M.J., Watt J.D., Jones, M., Kazmierczak, K., Szczesna-Cordary, D., Moore, J.,R., (2009).Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanicsand kinetics. J Mol Cell Cardiol. Jan;46(1):108-15. PMCID: PMC2675789. Pub Med

Greenberg, M., Wang, C-L., Lehman, W., Moore, J., (2008) Modulation of actin mechanics by caldesmon and tropomyosin. Cell Motility and Cytoskeleton. Feb;65(2):156-64. PMCID: PMC2975105. Pub Med

Szczesna-Cordary, D., Jones, M., Moore, J., Watt, J., Kerrick, G., Xu, Y., Wang, Y., Wagg, C., and Lopaschuk, G. (2007) Myosin Regulatory Light Chain E22K Mutation Results in Decreased Cardiac Intracellular Calcium and Force Transients. FASEB J. Dec;21(14):3974-85.

Debold, E., Schmitt, J., Moore, J., Patlak, J., Beck, S., Seidman, J., Seidman, C., Warshaw, D. (2007) Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse a-cardiac myosin in the laser trap assay. Am J Physiol Heart Circ Physiol. Mar 9; Jul;293(1):H284-91

Moore, J., (2005) Stretch activation: Toward a molecular mechanism. in “Nature’s Versatile engine: Insect flight muscle Inside and Out”, Vigoreaux J., ed., Landes Bioscience Publishers.

Moore, J., Krementsova, E., Trybus, K., Warshaw, D.,(2004) Is the myosin V neck a compliant lever?, J. Mus. Res. Cell Motil. 25(1):29-35.

Irving T, Bhattacharya S, Tesic I, Moore, J., Farman, Simcox A, Vigoreaux J, Maughan D. (2001) Changes in myofibrillar structure and function produced by N-terminal deletion of the regulatory light chain in Drosophila. Submitted to J. Mus. Res. Cell Motil., 22(8):675-83.

Moore, J., Krementsova E, Trybus K, Warshaw D. (2001) Myosin V exhibits a high duty cycle and large unitary displacement, J. Cell Biol.,155 (4): 625-635 .
*See also Wells. W. (2001) “Myosin V: tight grip and big steps” J. Cell Biol.,155 (4): 495.

Moore, J., Dickinson M, Vigoreaux J, Maughan D. (2000) The Effect of removing the N-terminal extension of the Drosophila Myosin Regulatory Light Chain Upon Flight Ability and the Contractile Dynamics of Indirect Flight Muscle. Biophys J. 78: 1431-1440.PMCID: PMC1300741.

Vigoreaux J, Moore, J., Maughan D. (2000) Role of the elastic protein projectin in stretch activation and work output of Drosophila flight muscles. in “Elastic Filaments of the Cell”, Pollack G. and Granzier H, eds., Kluwer Academic/Plenum Publishers

Moore, J., Vigoreaux J, Maughan D. (1999) The Projectin mutant bentD/+ has reduced stretch activation and altered indirect flight muscle kinetics.J. Mus. Res. Cell Motil. 20: 797-806.

Maughan D, Moore, J., Vigoreaux J, Barnes B, Mulieri LA. (1998) Work production and work absorption in muscle strips from vertebrate cardiac and insect flight muscle fibers. Adv Exp Med Biol., 453:471-80

Vigoreaux JO, Hernandez C, Moore, J., Ayer G, Maughan D. (1998) A genetic deficiency that spans the flightin gene of Drosophila melanogaster affects the ultrastructure and function of the flight muscles. J Exp Biol., 201 ( Pt 13):2033-44

Dickinson MH, Hyatt CJ, Lehmann FO, Moore, J., Reedy MC, Simcox A, Tohtong R, Vigoreaux JO, Yamashita H, Maughan DW. (1997) Phosphorylation-dependent power output of transgenic flies: an integrated study. Biophys J.. 73(6):3122-34

Book Chapters

Moore, J., (2005) Stretch activation: Toward a molecular mechanism. in “Nature’s Versatile engine: Insect flight muscle Inside and Out”, Vigoreaux J., ed., Landes Bioscience Publishers.