Tanya Mealy – Research Technician

Dr. Jeffrey R. Moore
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Education

2000
Certificate in Biotechnology
Boston University School of Medicine, Boston, MA

1988
B.A.
Harvard University, Cambridge MA
(General Sciences)

Publications

Oshry L, Meers P, Mealy T, Pavlotsky N, Tauber AI. Annexin-mediated membrane fusion in human neutrophils.  Trans Assoc Am Physicians. 1991;104:213-220.

Oshry L, Meers P, Mealy T, Tauber AI. Annexin-mediated membrane fusion of human neutrophil plasma membranes and phospholipid vesicles.  Biochim Biophys Acta. 1991; 1066:239-244.

Meers P, Mealy T, Pavlotsky N, Tauber AI. Annexin I-mediated vesicular aggregation: mechanism and role in human neutrophils. Biochemistry. 1992; 31:6372-6382.

Meers P, Mealy T, Tauber AI. Annexin I interactions with human neutrophil specific granules: fusogenicity and coaggregation with plasma membrane vesicles.  Biochim Biophys Acta. 1993;1147:177-184.

Meers P, Mealy T. Relationship between annexin V tryptophan exposure, calcium, and phospholipid binding. Biochemistry. 1993; 32:5411-5418.

Meers P, Mealy T. Calcium-dependent annexin V binding to phospholipids: stoichiometry, specificity, and the role of negative charge.  Biochemistry. 1993; 32:11711-11721.

Meers P, Mealy T. Phospholipid determinants for annexin V binding sites and the role of tryptophan 187. Biochemistry. 1994; 33:5829-5837.

Campos B, Mo YD, Mealy TR, Li CW, Swairjo MA, Balch C, Head JF, Retzinger G, Dedman JR, Seaton BA. Mutational and crystallographic analyses of interfacial residues in annexin V suggest direct interactions with phospholipid membrane components.  Biochemistry. 1998; 37:8004-8010.

Wu F, Gericke A, Flach CR, Mealy TR, Seaton BA, Mendelsohn R.Domain structure and molecular conformation in annexin V/1,2-dimyristoyl-sn-glycero-3-phosphate/Ca2+ aqueous monolayers: a Brewster angle microscopy/infrared reflection-absorption spectroscopy study.  Biophys J. 1998; 74:3273-3281.

Wu F, Flach CR, Seaton BA, Mealy TR, Mendelsohn R. Stability of annexin V in ternary complexes with Ca2+ and anionic phospholipids: IR studies of monolayer and bulk phases.  Biochemistry. 1999; 38:792-799.

Capila I, VanderNoot VA, Mealy TR, Seaton BA, Linhardt RJ.Interaction of heparin with annexin V.  FEBS Lett. 1999; 446:327-330.
Kaetzel MA, Mo YD, Mealy TR, Campos B, Bergsma-Schutter W, Brisson A, Dedman JR, Seaton BA. Phosphorylation mutants elucidate the mechanism of annexin IV-mediated membrane aggregation.  Biochemistry. 2001; 40:4192-4199.

Capila I, Hernaiz MJ, Mo YD, Mealy TR, Campos B, Dedman JR, Linhardt RJ, Seaton BA. Annexin V—heparin oligosaccharide complex suggests heparan sulfate—mediated assembly on cell surfaces.  Structure. 2001; 9:57-64.
Alekshun MN, Levy SB, Mealy TR, Seaton BA, Head JF.The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolution. Nat Struct Biol. 2001; 8:710-4.

Mo Y, Campos B, Mealy TR, Commodore L, Head JF, Dedman JR, Seaton BA. Interfacial basic cluster in annexin V couples phospholipid binding and trimer formation on membrane surfaces.  J Biol Chem. 2003; 278:2437-2443.

Head JF, Mealy TR, McCormack FX, Seaton BA.Crystal structure of trimeric carbohydrate recognition and neck domains of surfactant protein A. J Biol Chem. 2003; 278:43254-43260.

Crouch E, McDonald B, Smith K, Cafarella T, Seaton B, Head J. Contributions of phenylalanine 335 to ligand recognition  by human surfactant protein D: ring interactions with SP-D ligands.
J Biol Chem. 2006 Jun 30;281(26):18008-14. Epub 2006 Apr 24.

Directory|BUMC
June 10, 2010
Primary teaching affiliate
of BU School of Medicine