||Opportunities exist for federally funded postdoctoral and graduate studies. Interested candidates should contact Dr. Jeffrey Moore to discuss the potential for being an active member of an exciting researcher collaboration that focuses on the structure and mechanics of smooth muscle thin filaments.
Lab Mailing address:
Jeffrey R. Moore
Boston University School of Medicine
Dept. Physiology and Biophysics
Instructional Bldg. L
72 E. Concord St.
Boston, MA 02118
Dr. Jeffrey Moore is associated with two graduate programs within Boston University:
- Physiology and Biophysics
- Cell and Molecular Biology
Contact Dr. Jeffrey Moore or the programs directly for more information.
Potential Rotation Projects
- Calcium regulation of cardiac muscle contraction.
Use steady-state biochemical methods to investigate the effects of calcium on myosin ATPase activity and actin filament velocity.
Techniques: cloning, bacterial expression, protein purification, biochemical assays, in vitro motility assays.
- Biochemistry of muscle fatigue.
Use steady-state biochemical methods to investigate the effects of metabolites on myosin ATPase activity and actin filament velocity.
Techniques: protein purification, biochemical assays, in vitro motility assays
- Characterization of the effects of myosin regulatory light chain mutations on contractile function.
Techniques: protein purification, in vitro motility assays, optical trapping force measurements, and single molecule mechanics and kinetics.
- Characterization of cytoskeletal filament mechanics and actin binding protein interactions.
Techniques: protein purification, fluorescence microscopy and optical trapping.
For more details on projects click here