Sudha Seshadri, MD

Professor of Neurology
Boston University School of Medicine
72 East Concord Street, B 605
Boston, MA 02118

Phone: 617-414-1337
Fax: 617-617-638-8086
Email: suseshad@bu.edu

Medical School: Madras University (Christian Medical College, Vellore and Madras Medical College, Madras)- 1986
Residency: All India Institute of Medical Sciences, New Delhi (Internal Medicine, 1988 and Neurology 1992) and Boston University School of Medicine Neurology, (2005)
Board Certifications: Neurology
Special Interests: Alzheimer’s Disease, Stroke, Vascular Cognitive Impairment, Neuroepidemiology

 

Recent Publications

Broer L, Buchman AS, Deelen J, Evans DS, Faul JD, Lunetta KL, Sebastiani P, Smith JA, Smith AV, Tanaka T, Yu L, Arnold AM, Aspelund T, Benjamin EJ, De Jager PL, Eirkisdottir G, Evans DA, Garcia ME, Hofman A, Kaplan RC, Kardia SL, Kiel DP, Oostra BA, Orwoll ES, Parimi N,Psaty BM, Rivadeneira F, Rotter JI, Seshadri S, Singleton A, Tiemeier H, Uitterlinden AG, Zhao W, Bandinelli S, Bennett DA, Ferrucci L, Gudnason V, Harris TB, Karasik D, Launer LJ, Perls TT, Slagboom PE, Tranah GJ, Weir DR, Newman AB, van Duijn CM, Murabito JM. GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy. J Gerontol A Biol Sci Med Sci. 2014 Sep 8. pii: glu166.

Gupta A, Preis SR, Beiser A, Devine S, Hankee L, Seshadri S, Wolf PA, Au R. Mid-life Cardiovascular Risk Impacts Memory Function: The Framingham Offspring Study. Alzheimer Dis Assoc Disord. 2014 Sep 1.

Weinstein G, Seshadri S. Circulating biomarkers that predict incident dementia. Alzheimers Res Ther. 2014 Jan 21;6(1):6. doi: 10.1186/alzrt235. eCollection 2014. Review.

Kilarski LL, Achterberg S, Devan WJ, Traylor M, Malik R, Lindgren A, Pare G, Sharma P, Slowik A, Thijs V, Walters M, Worrall BB, Sale MM, Algra A, Kappelle LJ, Wijmenga C, Norrving B, Sandling JK, Rönnblom L, Goris A, Franke A, Sudlow C, Rothwell PM, Levi C, Holliday EG, Fornage M, Psaty B, Gretarsdottir S, Thorsteinsdottir U, Seshadri S, Mitchell BD, Kittner S, Clarke R, Hopewell JC, Bis JC, Boncoraglio GB, Meschia J, Ikram MA, Hansen BM, Montaner J, Thorleifsson G, Stefanson K, Rosand J, de Bakker PI, Farrall M, Dichgans M, Markus HS, Bevan S; GARNET Collaborative Research Group, Wellcome Trust Case Control Consortium 2, Australian Stroke Genetic Collaborative, the METASTROKE Consortium, and the International Stroke Genetics Consortium. Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. Neurology. 2014 Aug 19;83(8):678-85. doi: 10.1212/WNL.0000000000000707. Epub 2014 Jul 16.

Bis JC, DeStefano A, Liu X, Brody JA, Choi SH, Verhaaren BF, Debette S, Ikram MA, Shahar E, Butler KR Jr, Gottesman RF, Muzny D, Kovar CL, Psaty BM, Hofman A, Lumley T, Gupta M, Wolf PA, van Duijn C, Gibbs RA, Mosley TH, Longstreth WT Jr, Boerwinkle E, Seshadri S, Fornage M. Associations of NINJ2 sequence variants with incident ischemic stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) consortium. PLoS One. 2014 Jun 24;9(6):e99798. doi: 10.1371/journal.pone.0099798. eCollection 2014.

Weinstein G, Beiser AS, Choi SH, Preis SR, Chen TC, Vorgas D, Au R, Pikula A, Wolf PA, Destefano AL, Vasan RS, Seshadri S. Serum Brain-Derived Neurotrophic Factor and the Risk for Dementia: The Framingham Heart Study. JAMA Neurol. 2013 Nov 25.

Pikula A, Beiser AS, Chen TC, Preis SR, Vorgias D, Decarli C, Au R, Kelly-Hayes M, Kase CS, Wolf PA, Vasan RS, Seshadri S. Serum Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor Levels Are Associated With Risk of Stroke and Vascular Brain Injury: Framingham Study. Stroke 2013. Aug 8 (ahead of print)

Romero JR, Mercado M, Beiser AS, Pikula A, Seshadri S, Kelly-Hayes M, Wolf PA, Kase CS. Transient global amnesia and neurological events: the Framingham Heart Study. Front Neurol 2013;4:47.

Williams FM, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, Traylor M, Bevan S, Dichgans M, Rothwell PM, Sudlow C, Farrall M, Silander K, Kaunisto M, Wagner P, Saarela O, Kuulasmaa K, Virtamo J, Salomaa V, Amouyel P, Arveiler D, Ferrieres J, Wiklund PG, Arfan Ikram M, Hofman A, Boncoraglio GB, Parati EA, Helgadottir A, Gretarsdottir S, Thorsteinsdottir U, Thorleifsson G, Stefansson K, Seshadri S, et al. ; EuroCLOT Investigators the Wellcome Trust Case Control Consortium 2 MOnica Risk, Genetics, Archiving and Monograph MetaStroke and the International Stroke Genetics Consortium. Ischemic stroke is associated with the ABO locus: The EuroCLOT study. Ann Neurol 2013;73(1):16-31.

Weinstein G, Beiser AS, Au R, Decarli C, Wolf PA, Seshadri S. Association of parental stroke with brain injury and cognitive measures in offspring: the Framingham Heart Study. Stroke 2013;44(3):812-5.

Nyborn JA, Himali JJ, Beiser AS, Devine SA, Du Y, Kaplan E, O’Connor MK, Rinn WE, Denison HS, Seshadri S, Wolf PA, Au R. The Framingham Heart Study clock drawing performance: normative data from the offspring cohort. Exp Aging Res 2013;39:80-108.

Ahl RE, Beiser A, Seshadri S, Auerbach S, Wolf PA, Au R. Defining MCI in the Framingham Heart Study Offspring: Education Versus WRAT-based Norms.
Alzheimer Dis Assoc Disord. 2013 Jan 14.

Chen MH, Huang J, Chen WM, Larson MG, Fox CS, Vasan RS, Seshadri S, O’Donnell CJ, Yang Q. Using family-based imputation in genome-wide association studies with large complex pedigrees: the Framingham Heart Study. PLoS One. 2012;7(12):e51589.

Maillard P, Seshadri S, Beiser A, Himali JJ, Au R, Fletcher E, Carmichael O, Wolf PA, DeCarli C. Effects of systolic blood pressure on white-matter integrity in young adults in the Framingham Heart Study: a cross-sectional study. Lancet Neurol 2012;11(12):1039-47.

Traylor M, Farrall M, Holliday EG, Sudlow C, Hopewell JC, Cheng YC, Fornage M, Ikram MA, Malik R, Bevan S, Thorsteinsdottir U, Nalls MA, Longstreth W, Wiggins KL, Yadav S, Parati EA, Destefano AL, Worrall BB, Kittner SJ, Khan MS, Reiner AP, Helgadottir A, Achterberg S, Fernandez-Cadenas I, Abboud S, Schmidt R, Walters M, Chen WM, Ringelstein EB, O’Donnell M, Ho WK, Pera J, Lemmens R, Norrving B, Higgins P, Benn M, Sale M, Kuhlenbäumer G, Doney AS, Vicente AM, Delavaran H, Algra A, Davies G, Oliveira SA, Palmer CN, Deary I, Schmidt H, Pandolfo M, Montaner J, Carty C, de Bakker PI, Kostulas K, Ferro JM, van Zuydam NR, Valdimarsson E, Nordestgaard BG, Lindgren A, Thijs V, Slowik A, Saleheen D, Paré G, Berger K, Thorleifsson G; Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2), Hofman A, Mosley TH, Mitchell BD, Furie K, Clarke R, Levi C, Seshadri S, Gschwendtner A, Boncoraglio GB, Sharma P, Bis JC, Gretarsdottir S, Psaty BM, Rothwell PM, Rosand J, Meschia JF, Stefansson K, Dichgans M, Markus HS; International Stroke Genetics Consortium.Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol 2012;11(11):951-62.

Romero JR, Preis SR, Beiser AS, DeCarli C, Lee DY, Viswanathan A, Benjamin EJ, Fontes J, Au R, Pikula A, Wang J, Kase CS, Wolf PA, Irrizary MC, Seshadri S. Lipoprotein Phospholipase A2 and Cerebral Microbleeds in the Framingham Heart Study. Stroke September 2012

Weinstein G, Wolf PA, Beiser AS, Au R, Seshadri S.  Risk Estimations, Risk Factors, and Genetic Variants Associated with Alzheimer’s Disease in Selected Publications from the Framingham Heart Study. Alzheimers Dis. 2012 Jul 12.

Pikula A, Beiser AS, DeCarli C, Himali JJ, Debette S, Au R, Selhub J, Toffler GH, Wang TJ, Meigs JB, Kelly-Hayes M, Kase CS, Wolf PA, Vasan RS, Seshadri S.
Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study.Circulation. 2012;125(17):2100-7.

Westwood AJ, Perloff MD, McGeeney BE, Seshadri S. Constructional apraxia reversed with methylprednisolone. J Neuropsychiatry Clin Neurosci. 2012;24(2):E51-2.

Kao PF, Banigan MG, Vanderburg CR, McKee AC, Polgar PR, Seshadri S, Delalle I. Increased Expression of TrkB and Capzb2 Accompanies Preserved Cognitive Status in Early Alzheimer Disease Pathology. J Neuropathol Exp Neurol. 2012;71(7):654-64.

Bis JC, DeCarli C, Smith AV, van der Lijn F, Crivello F, Fornage M, Debette S, Shulman JM, Schmidt H, Srikanth V, Schuur M, Yu L, Choi SH, Sigurdsson S, Verhaaren BF, DeStefano AL, Lambert JC, Jack CR Jr, Struchalin M, Stankovich J, Ibrahim-Verbaas CA, Fleischman D, Zijdenbos A, den Heijer T, Mazoyer B, Coker LH, Enzinger C, Danoy P, Amin N, Arfanakis K, van Buchem MA, de Bruijn RF, Beiser A, Dufouil C, Huang J, Cavalieri M, Thomson R, Niessen WJ, Chibnik LB, Gislason GK, Hofman A, Pikula A, Amouyel P, Freeman KB, Phan TG, Oostra BA, Stein JL, Medland SE, Vasquez AA, Hibar DP, Wright MJ, Franke B, Martin NG, Thompson PM; Enhancing Neuro Imaging Genetics through Meta-Analysis Consortium, Nalls MA, Uitterlinden AG, Au R, Elbaz A, Beare RJ, van Swieten JC, Lopez OL, Harris TB, Chouraki V, Breteler MM, De Jager PL, Becker JT, Vernooij MW, Knopman D, Fazekas F, Wolf PA, van der Lugt A, Gudnason V, Longstreth WT Jr, Brown MA, Bennett DA, van Duijn CM, Mosley TH, Schmidt R, Tzourio C, Launer LJ, Ikram MA, Seshadri S; Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nat Genet 2012;44(5):545-51.

Seshadri S. Homocysteine and the risk of dementia. Clin Chem 2012;58(6):1059-60.

Taal HR, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, Warrington NM, Kaakinen M, Kreiner-Møller E, Bradfield JP, Freathy RM, Geller F, Guxens M, Cousminer DL, Kerkhof M, Timpson NJ, Ikram MA, Beilin LJ, Bønnelykke K, Buxton JL, Charoen P, Chawes BL, Eriksson J, Evans DM, Hofman A, Kemp JP, Kim CE, Klopp N, Lahti J, Lye SJ, McMahon G, Mentch FD, Müller-Nurasyid M, O’Reilly PF, Prokopenko I, Rivadeneira F, Steegers EA, Sunyer J, Tiesler C, Yaghootkar H; Cohorts for Heart and Aging Research in Genetic Epidemiology Consortium, Breteler MM, Decarli C, Breteler MM, Debette S, Fornage M, Gudnason V, Launer LJ, van der Lugt A, Mosley TH Jr, Seshadri S, …..Heinrich J, Jarvelin MR, Jaddoe VW; Early Growth Genetics Consortium. Common variants at 12q15 and 12q24 are associated with infant head circumference. Nat Genet. 2012;44(5):532-8.

Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, Vrooman HA, Sigurdsson S, Ropele S, Taal HR, Mook-Kanamori DO, Coker LH, Longstreth WT Jr, Niessen WJ, DeStefano AL, Beiser A, Zijdenbos AP, Struchalin M, Jack CR Jr, Rivadeneira F, Uitterlinden AG, Knopman DS, Hartikainen AL, Pennell CE, Thiering E, Steegers EA, Hakonarson H, Heinrich J, Palmer LJ, Jarvelin MR, McCarthy MI, Grant SF, St Pourcain B, Timpson NJ, Smith GD, Sovio U; Early Growth Genetics Consortium, Nalls MA, Au R, Hofman A, Gudnason H, van der Lugt A, Harris TB, Meeks WM, Vernooij MW, van Buchem MA, Catellier D, Jaddoe VW, Gudnason V, Windham BG, Wolf PA, van Duijn CM, Mosley TH Jr, Schmidt H, Launer LJ, Breteler MM, DeCarli C; Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Common variants at 6q22 and 17q21 are associated with intracranial volume. Nat Genet 2012;44(5):539-44.

Stein JL, Medland SE, Vasquez AA, Hibar DP, Senstad RE, Winkler AM, Toro R, Appel K, Bartecek R, ….; Alzheimer’s Disease Neuroimaging Initiative; EPIGEN Consortium; IMAGEN Consortium; Saguenay Youth Study Group, Bis JC, Ikram MA, Smith AV, Gudnason V, Tzourio C, Vernooij MW, Launer LJ, DeCarli C, Seshadri S; ……Smoller JW, Wardlaw JM, Weale ME, Martin NG, Franke B, Wright MJ, Thompson PM; Enhancing Neuro Imaging Genetics through Meta-Analysis Consortium. Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet 2012;44:552-61.

Au R, Seshadri S, Knox K, Beiser A, Himali JJ, Cabral HJ, Auerbach S, Green RC, Wolf PA, McKee AC. The Framingham Brain Donation Program: Neuropathology Along The Cognitive Continuum. Curr Alzheimer Res 2012 Apr 2.

Driver JA, Beiser A, Au R, Kreger BE, Splansky GL, Kurth T, Kiel DP, Lu KP, Seshadri S, Wolf PA. Inverse association between cancer and Alzheimer’s disease: results from the Framingham Heart Study. BMJ 2012;344:e1442.

Tan ZS, Harris WS, Beiser AS, Au R, Himali JJ, Debette S, Pikula A, Decarli C, Wolf PA, Vasan RS, Robins SJ,Seshadri S. Red blood cell ω-3 fatty acid levels and markers of accelerated brain aging. Neurology 2012;78(9):658-64.

Hsieh YC, Seshadri S, Chung WT, Hsieh FI, Hsu YH, Lin HJ, Tseng HP, Lien LM, Bai CH, Hu CJ, Jeng JS, Tang SC, Chen CI, Yu CC, Chiou HY. Association between genetic variant on Chromosome 12p13 and stroke survival and recurrence: A one year prospective study in Taiwan. J Biomed Sci. 2012;19(1):1.

Barral S, Fernández-Cadenas I, Bis JC, Montaner J, Ikram AM, Launer LJ, Fornage M, Schmidt H, Brickman AM,Seshadri S, Mayeux R. No association of ALOX5AP polymorphisms with risk of MRI-defined brain infarcts. Neurobiol Aging. 2012 Mar;33(3):629.e1-3

van Himbergen TM, Beiser AS, Ai M, Seshadri S, Otokozawa S, Au R, Thongtang N, Wolf PA, Schaefer EJ. Biomarkers for Insulin Resistance and Inflammation and the Risk for All-Cause Dementia and Alzheimer Disease: Results From the Framingham Heart Study. Arch Neurol. 2012 Jan 2.

Poly C, Massaro JM, Seshadri S, Wolf PA, Cho E, Krall E, Jacques PF, Au R. The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort. Am J Clin Nutr 2011;94(6):1584-91

Jefferson AL, Himali JJ, Au R, Seshadri S, Decarli C, O’Donnell CJ, Wolf PA, Manning WJ, Beiser AS, Benjamin EJ. Relation of left ventricular ejection fraction to cognitive aging (from the Framingham Heart Study). Am J Cardiol. 2011;108(9):1346-51

Schnabel RB, Kerr KF, Lubitz SA, Alkylbekova EL, Marcus GM, Sinner MF, Magnani JW, Wolf PA, Deo R, Lloyd-Jones DM, Lunetta KL, Mehra R, Levy D, Fox ER, Arking DE, Mosley TH, Müller-Nurasyid M, Young TR, Wichmann HE, Seshadri S, Farlow DN, Rotter JI, Soliman EZ, Glazer NL, Wilson JG, Breteler MM, Sotoodehnia N, Newton-Cheh C, Kääb S, Ellinor PT, Alonso A, Benjamin EJ, Heckbert SR; Candidate Gene Association Resource (CARe) Atrial Fibrillation/Electrocardiography Working Group. Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute’s Candidate Gene Association Resource (CARe) project. Circ Cardiovasc Genet. 2011;4(5):557-64.

Zade D, Beiser A, McGlinchey R, Au R, Seshadri S, Palumbo C, Wolf PA, Decarli C, Milberg W. Apolipoprotein Epsilon 4 Allele Modifies Waist-to-Hip Ratio Effects on Cognition and Brain Structure. J Stroke Cerebrovasc Dis. 2011 Aug 9

Debette S, Seshadri S, Beiser A, Au R, Himali JJ, Palumbo C, Wolf PA, DeCarli C. Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline.Neurology 2011;77(5):461-8

Jefferson AL, Massaro JM, Beiser AS, Seshadri S, Larson MG, Wolf PA, Au R, Benjamin EJ. Inflammatory markers and neuropsychological functioning: the Framingham Heart Study. Neuroepidemiology. 2011;37(1):21-30

Fornage M, Debette S, Bis JC, Schmidt H, Ikram MA, Dufouil C, Sigurdsson S, Lumley T, DeStefano AL, Fazekas F, Vrooman HA, Shibata DK, Maillard P, Zijdenbos A, Smith AV, Gudnason H, de Boer R, Cushman M, Mazoyer B, Heiss G, Vernooij MW, Enzinger C, Glazer NL, Beiser A, Knopman DS, Cavalieri M, Niessen WJ, Harris TB, Petrovic K, Lopez OL, Au R, Lambert JC, Hofman A, Gottesman RF, Garcia M, Heckbert SR, Atwood LD, Catellier DJ, Uitterlinden AG, Yang Q, Smith NL, Aspelund T, Romero JR, Rice K, Taylor KD, Nalls MA, Rotter JI, Sharrett R, van Duijn CM, Amouyel P, Wolf PA, Gudnason V, van der Lugt A, Boerwinkle E, Psaty BM, Seshadri S, Tzourio C, Breteler MM, Mosley TH, Schmidt R, Longstreth WT, DeCarli C, Launer LJ. Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. Ann Neurol. 2011 Jun;69(6):928-39

Tan ZS, Beiser AS, Fox CS, Au R, Himali JJ, Debette S, Decarli C, Vasan RS, Wolf PA, Seshadri S. Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the Framingham Offspring Study. Diabetes Care 2011;34(8):1766-70

Seshadri S, Beiser A, Au R, Wolf PA, Evans DA, Wilson RS, Petersen RC, Knopman DS, Rocca WA, Kawas CH, Corrada MM, Plassman BL, Langa KM, Chui HC.Operationalizing diagnostic criteria for Alzheimer’s disease and other age-related cognitive impairment-Part 2. Alzheimers Dement. 2011;7(1):35-52

Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW, Seshadri S; American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Council on Cardiovascular Radiology and Intervention, and Council on Cardiovascular Surgery and Anesthesia. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke 2011;42(9):2672-713.

Debette S, Beiser A, Hoffmann U, Decarli C, O’Donnell CJ, Massaro JM, Au R, Himali JJ, Wolf PA, Fox CS, Seshadri S.Visceral fat is associated with lower brain volume in healthy middle-aged adults. Ann Neurol 2010;68(2):136-44.

Jefferson AL, Himali JJ, Beiser AS, Au R, Massaro JM,Seshadri S, Gona P, Salton CJ, DeCarli C, O’Donnell CJ, Benjamin EJ, Wolf PA, Manning WJ. Cardiac index is associated with brain aging: the Framingham Heart Study. Circulation 2010;122(7):690-7.

Saczynski JS, Beiser A, Seshadri S, Auerbach S, Wolf PA, Au R. Depressive symptoms and risk of dementia: the Framingham Heart Study. Neurology 2010;75(1):35-41.

Stavitsky K, Du Y, Seichepine D, Laudate TM, Beiser A, Seshadri S, Decarli C, Wolf PA, Au R. White matter hyperintensity and cognitive functioning in the racial and ethnic minority cohort of the Framingham Heart Study.
Neuroepidemiology 2010;35(2):117-22.

Albert M, Massaro J, DeCarli C, Beiser A, Seshadri S, Wolf PA, Au R. Profiles by sex of brain MRI and cognitive function in the framingham offspring study. Alzheimer Dis Assoc Disord. 2010;24(2):190-3.

Zade D, Beiser A, McGlinchey R, Au R, Seshadri S, Palumbo C, Wolf PA, Decarli C, Milberg W. Interactive effects of apolipoprotein E type 4 genotype and cerebrovascular risk on neuropsychological performance and structural brain changes. J Stroke Cerebrovasc Dis 2010;19(4):261-8.

Seshadri S, Fitzpatrick AL, Ikram MA, DeStefano AL, et al.; CHARGE Consortium; GERAD1 Consortium; EADI1 Consortium. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 2010;303(18):1832-40.

Seshadri S, Beiser A, Pikula A, Himali JJ, Kelly-Hayes M, Debette S, DeStefano AL, Romero JR, Kase CS, Wolf PA.Parental occurrence of stroke and risk of stroke in their children: the Framingham study. Circulation 2010;121(11):1304-12.

Romero JR, Beiser A, Seshadri S, Benjamin EJ, Polak JF, Vasan RS, Au R, Decarli C, Wolf PA. Carotid Artery Atherosclerosis, MRI Indices of Brain Ischemia, Aging, and Cognitive Impairment. The Framingham Study. Stroke 2009;40.

Ikram MA, Seshadri S, Bis JC, et al. Genomewide association studies of stroke. N Engl J Med 2009;360(17):1718-28.

Das RR, Seshadri S, Beiser AS, Kelly-Hayes M, Au R, Himali JJ, Kase CS, Benjamin EJ, Polak JF, O’Donnell CJ, Yoshita M, D’Agostino RB Sr, DeCarli C, Wolf PA. Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study. Stroke 2008;39(11):2929-35.

Romero JR, Vasan RS, Beiser AS, Polak JF, Benjamin EJ, Wolf PA, Seshadri S. Association of carotid artery atherosclerosis with circulating biomarkers of extracellular matrix remodeling: the Framingham Offspring Study. J Stroke Cerebrovasc Dis 2008;17(6):412-7.

Petrea RE, Beiser AS, Seshadri S, Kelly-Hayes M, Kase CS, Wolf PA. Gender Differences in Stroke Incidence and Poststroke Disability in the Framingham Heart Study. Stroke 2009;40:1032-7.

Jefferson AL, Massaro JM, Wolf PA, Seshadri S, Au R, Vasan R, Larson MG, Meigs JB, Keaney JF, Lipinska I, Kathiresan S, Benjamin EJ, DeCarli C.Inflammatory Biomarkers are Associated with Total Brain Volume: The Framingham Heart Study. Neurology 2007;68:1032-1038.

Wolf PA, Beiser A, Elias MF, Au R, Vasan RS, Seshadri S. Relation of Obesity to Cognitive Function: Importance of Central Obesity and Synergistic Influence of Concomitant Hypertension. The Framingham Heart study. Current Alzheimer Research 2007;4:111-116.

Tan ZS, Beiser AS, Vasan RS, Roubenoff R, Dinarello CA, Harris TB, Benjamin EJ, Au R, Kiel DP, Wolf PA, Seshadri S. Inflammatory markers and the risk of Alzheimer’s disease: The Framingham Study. Neurology 2007;68:1902-1908.

Seshadri S, DeStefano AL, Au R, Massaro JM, Beiser AS, Kelly-Hayes M, Kase CS, D’Agostino RB, DeCarli C, Atwood LD, Wolf PA. Genetic correlates of brain aging on MRI and cognitive test measures: a genome wide association and linkage analysis in the Framingham study. BMC Med Genet 2007.

Larson MG, Atwood LD, Benjamin EJ, Cupples LA, D’Agostino RB, Sr., Fox CS, Diddahally RG, Guo CY, Heard-Costa NL, Hwang SJ, Lunetta KL, Murabito JM, Newton-Cheh C, O’Connor GT, O’Donnell CJ, Seshadri S, Vasan RS, Wang TJ, Wolf PA, Levy D. Framingham Heart Study 100K Project: Genomewide Associations for Cardiovascular Disease Outcomes. BMC Med Genet 2007, 8.

Lunetta KL, D’Agostino, RB, Karasik D, Benjamin EJ, Guo CY, Govindaraju R, Kiel DP, Kelly-Hayes M, Massaro JM, Pencina MJ, Seshadri S, Murabito JM. Genetic Correlates of Longevity and Selected Age-related Phenotypes: Genome-wide Association Study in the Framingham Study. BMC Med Genet 2007, 8.

Cupples LA, Arruda H, Benjamin EJ, D’Agostino Sr RB, Demissie S, Destefano AL, Dupuis J, Falls K, Fox CS, Gottlieb DJ, Govindaraju DR, Guo CY, Heard-Costa N, Hwang SJ, Kathiresan S, Kiel DP, Larson MG, Laramie JM, Levy D, Liu CY, Lunetta KL, Mailman MD, Manning AK, Meigs JB, Murabito JM, Newton-Cheh C, O’Connor GT, O’Donnell CJ, Pandey MA, Qiong Y, Seshadri S, Vasan RS, Wilk JB, Wolf PA, Atwood LD: The Framingham Heart Study 100K SNP genome-wide association study resource: Overview of 17 phenotype working group reports. BMC Med Genet 2007, 8.

Seshadri S, Wolf PA, Besier A, Au R, Selhub J, Jacques PF, Rosenberg IH, D’Agostino RB, DeCarli C. Association of elevated plasma homocysteine levels with subclinical brain injury: relation to silent brain infarcts, white matter hyperintensity and MRI brain volume in the Framingham Offspring. Arch Neurol 2008; 65:642-649.

 

Primary teaching affiliate
of BU School of Medicine