Chief of Neurology – Carlos S. Kase, MD

Professor and ChairCarlos Kase
Boston University School of Medicine

72 East Concord Street, Neurology C-329
Boston, MA 02118

Phone: 617-638-7730
Fax: 617-638-7758

Medical School: Catholic University of Chile School of Medicine, Chile (1966)
Residency: Massachusetts General Hospital (1973)
Board Certifications: Neurology, Vascular Neurology
Special Interests: Stroke, Cerebrovascular Disease


Recent Publications

Saber H, Himali JJ, Shoamanesh A, Beiser A, Pikula A, Harris TB, Roubenoff R, Romero JR, Kase CS, Vasan RS, Seshadri S. Serum Leptin Levels and the Risk of Stroke: The Framingham Study. Stroke. 2015 Sep 3. pii: STROKEAHA.115.009463.

Zhu S, McClure LA, Lau H, Romero JR, White CL, Babikian V, Nguyen T, Benavente OR, Kase CS, Pikula A. Recurrent vascular events in lacunar stroke patients with metabolic syndrome and/or diabetes. Neurology. 2015 Aug 21. pii: 10.1212/WNL.0000000000001933.

Kase CS, Mohr JP, Martí-Fàbregas J. José Luis Martí Vilalta (1946-2014). Cerebrovasc Dis. 2015;40(1-2):99. doi: 10.1159/000437011.

Dey M, Stadnik A, Riad F, Zhang L, McBee N, Kase C, Carhuapoma JR, Ram M, Lane K, Ostapkovich N, Aldrich F, Aldrich C, Jallo J, Butcher K, Snider R, Hanley D, Ziai W, Awad IA. Bleeding and Infection With External Ventricular Drainage: A Systematic Review in Comparison With Adjudicated Adverse Events in the Ongoing Clot Lysis Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III (CLEAR-III IHV) Trial. Neurosurgery. 2015 Mar; 76(3):291-301.

Shoamanesh A, Preis SR, Beiser AS, Vasan RS, Benjamin EJ, Kase CS, Wolf PA, DeCarli C, Romero JR, Seshadri S. Inflammatory biomarkers, cerebral microbleeds, and small vessel disease: Framingham Heart Study. Neurology. 2015 Jan 28. pii: 10.1212/WNL.0000000000001279. [Epub ahead of print]

Pikula A, Beiser AS, Wang J, Himali JJ, Kelly-Hayes M, Kase CS, Yang Q, Seshadri S, Wolf PA. Lipid and lipoprotein measurements and the risk of ischemic vascular events: Framingham Study. Neurology. 2015 Feb 3;84(5):472-9. doi: 10.1212/WNL.0000000000001202. Epub 2015 Jan 7.

Weinstein G, Preis SR, Beiser AS, Au R, Kelly-Hayes M, Kase CS, Wolf PA, Seshadri S. Cognitive performance after stroke – The Framingham Heart Study. Int J Stroke. 2014 Oct;9 Suppl A100:48-54. doi: 10.1111/ijs.12275. Epub 2014 Apr 30.

Busza A, Cervantes-Arslanian AM, Kase CS. Clinical reasoning: a 32-year-old woman with right-sided numbness and word-finding difficulties. Neurology. 2014 Aug 26;83(9):e98-102. doi: 10.1212/WNL.0000000000000736.

Shoamanesh A, Masoud H, Furey K, Duerfeldt K, Lau H, Romero JR, Pikula A, Teal P, Nguyen TN, Kase CS, Babikian VL. Larger A1/M1 diameter ratio predicts embolic anterior cerebral artery territorial stroke. Stroke. 2014 Sep;45(9):2798-800.
doi: 10.1161/STROKEAHA.114.005672.

Shoamanesh A, Romero JR, Kase CS. Spontaneous cervical spinal epidural hematoma mimicking acute stroke. Can J Neurol Sci. 2014 Jul;41(4):533-4.

Romero JR, Preis SR, Beiser A, Decarli C, Viswanathan A, Martinez-Ramirez S, Kase CS, Wolf PA, Seshadri S. Risk Factors, Stroke Prevention Treatments, and Prevalence of Cerebral Microbleeds in the Framingham Heart Study. Stroke. 2014 Apr 8.

Culebras A, Messé SR, Chaturvedi S, Kase CS, Gronseth G. Summary of evidence-based guideline update: prevention of stroke in nonvalvular atrial fibrillation: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2014 Feb 25;82(8):716-24. doi: 10.1212/WNL.0000000000000145.

Rist PM, Glymour MM, Orav EJ, Kim E, Kase CS, Buring JE, Kurth T. Non-steroidal anti-inflammatory drug use and functional outcome from ischemic cerebral events among women. Eur J Intern Med. 2014 Mar;25(3):255-8. doi: 10.1016/j.ejim.2014.01.013.

Rodriguez-Luna D, Dowlatshahi D, Aviv RI, Molina CA, Silva Y, Dzialowski I, Lum C, Czlonkowska A, Boulanger JM, Kase CS, Gubitz G, Bhatia R, Padma V, Roy J, Stewart T, Huynh TJ, Hill MD, Demchuk AM; PREDICT/Sunnybrook ICH CTA Study Group. Venous phase of computed tomography angiography increases spot sign detection, but intracerebral hemorrhage expansion is greater in spot signs detected in arterial phase. Stroke. 2014 Mar;45(3):734-9. doi: 10.1161/STROKEAHA.113.003007.

Pikula A, Beiser AS, Chen TC, Preis SR, Vorgias D, DeCarli C, Au R, Kelly-Hayes M, Kase CS, Wolf PA, Vasan RS, Seshadri S. Serum brain-derived neurotrophic factor and vascular endothelial growth factor levels are associated with risk of stroke and vascular brain injury: Framingham Study. Stroke. 2013 Oct;44(10):2768-75. doi: 10.1161/STROKEAHA.113.001447.

Álvarez-Sabín J, Maisterra O, Santamarina E, Kase CS. Factors influencing haemorrhagic transformation in ischaemic stroke. Lancet Neurol. 2013 Jul;12(7):689-705. doi: 10.1016/S1474-4422(13)70055-3.

Romero JR, Mercado M, Beiser AS, Pikula A, Seshadri S, Kelly-Hayes M, Wolf PA, Kase CS. Transient global amnesia and neurological events: the framingham heart study. Front Neurol. 2013 May 14;4:47. doi: 10.3389/fneur.2013.00047.

Shoamanesh A, Catanese L, Sakai O, Pikula A, Kase CS. Diffusion-weighted imaging hyperintensities in intracerebral hemorrhage: microinfarcts or microbleeds? Ann Neurol. 2013 Jun;73(6):795-6. doi: 10.1002/ana.23853.

Burns JD, Green DM, Lau H, Winter M, Koyfman F, DeFusco CM, Holsapple JW, Kase CS. The effect of a neurocritical care service without a dedicated neuro-ICU on quality of care in intracerebral hemorrhage. Neurocrit Care. 2013 Jun;18(3):305-12. doi: 10.1007/s12028-013-9818-1.

Huynh TJ, Demchuk AM, Dowlatshahi D, Gladstone DJ, Krischek O, Kiss A, Hill MD, Molina CA, Rodriguez-Luna D, Dzialowski I, Silva Y, Czlonkowska A, Lum C, Boulanger JM, Gubitz G, Bhatia R, Padma V, Roy J, Kase CS, Aviv RI; PREDICT/Sunnybrook ICH CTA Study Group. Spot sign number is the most important spot sign characteristic for predicting hematoma expansion using first-pass computed tomography angiography: analysis from the PREDICT study. Stroke. 2013 Apr;44(4):972-7. doi: 10.1161/STROKEAHA.111.000410.

Connolly BJ, Pearce LA, Kurth T, Kase CS, Hart RG. Aspirin therapy and risk of subdural hematoma: meta-analysis of randomized clinical trials. J Stroke Cerebrovasc Dis. 2013 May;22(4):444-8. doi:10.1016/j.jstrokecerebrovasdis.2013.01.007.

Avetisyan R, Cabral H, Montouris G, Jarrett K, Shapiro GD, Berlowitz DR, Kase CS, Kazis LE. Evaluating racial/ethnic variations in outpatient epilepsy care. Epilepsy Behav. 2013 Apr;27(1):95-101. doi: 10.1016/j.yebeh.2012.12.020.

Rist PM, Buring JE, Kase CS, Kurth T. Effect of low-dose aspirin on functional outcome from cerebral vascular events in women. Stroke. 2013 Feb;44(2):432-6. doi: 10.1161/STROKEAHA.112.672451.

Rist PM, Buring JE, Kase CS, Ridker PM, Kurth T. Biomarkers and functional outcomes from ischaemic cerebral events in women: a prospective cohort study. Eur J Neurol. 2013 Feb;20(2):375-81. doi: 10.1111/j.1468-1331.2012.03874.x.

Romero JR, Preis SR, Beiser AS, DeCarli C, Lee DY, Viswanathan A, Benjamin EJ, Fontes J, Au R, Pikula A, Wang J, Kase CS, Wolf PA, Irrizary MC, Seshadri S.  Lipoprotein phospholipase A2 and cerebral microbleeds in the Framingham Heart Study. Stroke. 2012 Nov;43(11):3091-4. doi: 10.1161/STROKEAHA.112.656744.

Kase CS, Kurth T. Prevention of intracerebral hemorrhage recurrence. Continuum (Minneap Minn). 2011 Dec;17(6 2ndary Stroke Prevention):1304-17. doi: 10.1212/01.CON.0000410037.64971.e3. PubMed PMID: 22810032.

White CL, Szychowski JM, Roldan A, Benavente MF, Pretell EJ, Del Brutto OH, Kase CS, Arauz A, Meyer BC, Meissner I, Demaerschalk BM, McClure LA, Coffey CS, Pearce LA, Conwit R, Irby LH, Peri K, Pergola PE, Hart RG, Benavente OR; SPS3 Investigators. Clinical features and racial/ethnic differences among the 3020 participants in the Secondary Prevention of Small Subcortical Strokes (SPS3) trial. J Stroke Cerebrovasc Dis. 2013 Aug;22(6):764-74. doi: 10.1016/j.jstrokecerebrovasdis.2012.03.002.

Pikula A, Beiser AS, DeCarli C, Himali JJ, Debette S, Au R, Selhub J, Toffler GH, Wang TJ, Meigs JB, Kelly-Hayes M, Kase CS, Wolf PA, Vasan RS, Seshadri S. Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study. Circulation. 2012 May 1;125(17):2100-7. doi: 10.1161/CIRCULATIONAHA.110.989145. Epub 2012 Mar 28.

Demchuk AM, Dowlatshahi D, Rodriguez-Luna D, Molina CA, Blas YS, Dzialowski I, Kobayashi A, Boulanger JM, Lum C, Gubitz G, Padma V, Roy J, Kase CS, Kosior J, Bhatia R, Tymchuk S, Subramaniam S, Gladstone DJ, Hill MD, Aviv RI; PREDICT/Sunnybrook ICH CTA study group. Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot  sign (PREDICT): a prospective observational study. Lancet Neurol. 2012 Apr;11(4):307-14. doi: 10.1016/S1474-4422(12)70038-8.

Westwood AJ, Burns JD, Kase CS. Teaching NeuroImages: Isolated pineal hemorrhage. Neurology. 2011 Oct 18;77(16):e95. doi: 10.1212/WNL.0b013e318233b37f.

Rist PM, Lee IM, Kase CS, Gaziano JM, Kurth T. Physical activity and functional outcomes from cerebral vascular events in men. Stroke. 2011 Dec;42(12):3352-6. doi: 10.1161/STROKEAHA.111.619544.

Nguyen TN, Babikian VL, Romero R, Pikula A, Kase CS, Jovin TG, Norbash AM. Intra-arterial treatment methods in acute stroke therapy. Front Neurol. 2011 Mar 8;2:9. doi: 10.3389/fneur.2011.00009.


Primary teaching affiliate
of BU School of Medicine