Jiang-Fan Chen, MD, PhD
Professor of Neurology and Pharmacology
Boston University School of Medicine
72 East Concord Street, E-3
Boston, MA 02118
Phone: (617) 414-1249
Fax: (617) 638-5354
I received my MD training in China and my PhD in Pharmacology from Medical College of Pennsylvania in the USA, as well as postdoctoral training in transgenic mice at SUNY at Stony Brook. During my 8 years at Mass. General Hospital/Harvard Medical School (as postdoctoral fellow, instructor and then assistant professor), I, together with colleagues, generated and characterized adenosine A2A receptor knockout mice, and developed my expertise in adenosine receptor neurobiology. I joined the Dept of Neurology at Boston University School of Medicine in June 2001, and now direct the Molecular Neuropharmacology Lab, investigating the role of adenosine receptors in the development and treatment of neuropsychological disorders such as Parkinson’s disease, stroke, and more recently retinopathy. By coupling genetic knockout models with pharmacological approaches, my work significantly advances our knowledge of A2A receptor action under physiological and pathological conditions, providing support for the use of A2A antagonists as a novel treatment strategy for Parkinson’s disease, and contributes to the understanding of adenosine neurobiology in basal ganglia and neuropsychiatric disorders. I have published >110 papers on adenosine neurobiology in primary neuroscience journals. I have co-chaired several international conferences on “Targeting the adenosine A2A receptor in Parkinson’s disease” (2002 and 2006) and several other international conferences on adenosine biology. Most recently, my lab has made a major effort to generate several novel cell-type specific A2A receptor knockout models and uncover interesting distinct functions of the A2A receptor in various cellular elements. In summary, I have a demonstrated record of successful and productive research in the area of adenosine receptor neurobiology.
Labadorf A, Hoss AG, Lagomarsino V, Latourelle JC, Hadzi TC, Bregu J, MacDonald ME, Gusella JF, Chen JF, Akbarian S, Weng Z, Myers RH. RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression. PLoS One. 2015 Dec 4;10(12):e0143563. doi: 10.1371/journal.pone.0143563.
Dong X, Tsuji J, Labadorf A, Roussos P, Chen JF, Myers RH, Akbarian S, Weng Z. The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington’s Disease. PLoS One. 2015 Dec 4;10(12):e0144398. doi: 10.1371/journal.pone.0144398.
Shang P, He ZY, Chen JF, Huang SY, Liu BH, Liu HX, Wang XT. Absence of the Adenosine A2A Receptor Confers Pulmonary Arterial Hypertension Through RhoA/ROCK Signaling Pathway in Mice. J Cardiovasc Pharmacol. 2015 Dec; 66(6):569-75.
Hoss AG, Labadorf A, Latourelle JC, Kartha VK, Hadzi TC, Gusella JF, MacDonald ME, Chen JF, Akbarian S, Weng Z, Vonsattel JP, Myers RH. miR-10b-5p expression in Huntington”s disease brain relates to age of onset and the extent of striatal involvement. BMC Med Genomics. 2015 Dec; 8(1):83.
Matos M, Shen HY, Augusto E, Wang Y, Wei CJ, Wang YT, Agostinho P, Boison D, Cunha RA, Chen JF. Deletion of Adenosine A2A Receptors From Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia. Biol Psychiatry. 2015 Dec 1; 78(11):763-74.
Bai G, Cheung I, Shulha HP, Coelho JE, Li P, Dong X, Jakovcevski M, Wang Y, Grigorenko A, Jiang Y, Hoss A, Patel K, Zheng M, Rogaev E, Myers RH, Weng Z, Akbarian S, Chen JF. Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains. Hum Mol Genet. 2015 Mar 1;24(5):1441-56. doi: 10.1093/hmg/ddu561.
Chen JF. Adenosine receptor control of cognition in normal and disease. Int Rev Neurobiol. 2014; 119:257-307.
Chen JF, Lee CF, Chern Y. Adenosine receptor neurobiology: overview. Int Rev Neurobiol. 2014; 119:1-49.
Wang T, Xi NN, Chen Y, Shang XF, Hu Q, Chen JF, Zheng RY. Chronic caffeine treatment protects against experimental autoimmune encephalomyelitis in mice: therapeutic window and receptor subtype mechanism. Neuropharmacology. 2014 Nov;86:203-11. doi: 10.1016/j.neuropharm.2014.06.029.
Shen HY, Canas PM, Garcia-Sanz P, Lan JQ, Boison D, Moratalla R, Cunha RA, Chen JF. Adenosine A2A receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation. PLoS One. 2013; 8(11):e80902
Matos M, Augusto E, Agostinho P, Cunha RA, Chen JF. Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-a2 controlling glutamate uptake in astrocytes. J Neurosci. 2013 Nov 20; 33(47):18492-502.
Chiodi V, Mallozzi C, Ferrante A, Chen JF, Lombroso PJ, Di Stasi AM, Popoli P, Domenici MR. Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP. Neuropsychopharmacology. 2014 Feb; 39(3):569-78.
Hoss AG, Kartha VK, Dong X, Latourelle JC, Dumitriu A, Hadzi TC, Macdonald ME, Gusella JF, Akbarian S, Chen JF, Weng Z, Myers RH. MicroRNAs located in the Hox gene clusters are implicated in Huntington’s disease pathogenesis. PLoS Genet. 2014 Feb 27;10(2):e1004188. doi: 10.1371/journal.pgen.1004188.
Ning YL, Yang N, Chen X, Xiong RP, Zhang XZ, Li P, Zhao Y, Chen XY, Liu P, Peng Y, Wang ZG, Chen JF, Zhou YG. Adenosine A2A receptor deficiency alleviates blast-induced cognitive dysfunction. J Cereb Blood Flow Metab. 2013 Nov;33(11):1789-98. doi: 10.1038/jcbfm.2013.127.
Augusto E, Matos M, Sévigny J, El-Tayeb A, Bynoe MS, Müller CE, Cunha RA, Chen JF. Ecto-5′-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions. J Neurosci. 2013 Jul 10;33(28):11390-9. doi: 10.1523/JNEUROSCI.5817-12.2013.
Wei CJ, Augusto E, Gomes CA, Singer P, Wang Y, Boison D, Cunha RA, Yee BK, Chen JF. Regulation of fear responses by striatal and extrastriatal adenosine A2A receptors in forebrain. Biol Psychiatry. 2014 Jun 1;75(11):855-63. doi: 10.1016/j.biopsych.2013.05.003.
Chen JF, Eltzschig HK, Fredholm BB. Adenosine receptors as drug targets–what are the challenges? Nat Rev Drug Discov. 2013 Apr;12(4):265-86. doi: 10.1038/nrd3955. Review.
Lazarus M, Chen JF, Urade Y, Huang ZL. Role of the basal ganglia in the control of sleep and wakefulness. Curr Opin Neurobiol. 2013 Oct;23(5):780-5. doi: 10.1016/j.conb.2013.02.001. Epub 2013 Apr 24. Review.