Selected Publications


Sommer, C.A., Stadtfeld, M., Murphy, G.J., Hochedlinger, K., Kotton, D.N., Mostoslavsky, G. iPS Cell Generation Using a Single Lentiviral Stem Cell Cassette. Stem Cells. 2009 Mar;27(3):543-549. Epub 2008 Dec 18. Highlighted in Mol. Ther. 17(3), 2009:401.

Sommer, C.A., Gianotti Sommer, A., Longmire, T.A., Christodoulou, C., Gostissa, M., Alt, F.W., Murphy, G.J., Kotton, D.N., and Mostoslavsky, G. Excision of Reprogramming Transgenes Improves the Differentiation Potential of iPS Cells Generated with a Single Excisable Vector. Stem Cells. 2010 Jan;28(1):64-74. Epub Nov 10 2009.

Staerk, J., Dawlaty, M.M., Gao, Q., Maetzel, D., Hanna, J., Sommer, C.A., Mostoslavsky, G., and Jaenisch, R. Reprogramming of Human Peripheral Blood Cells to Induced Pluripotent Stem Cells. Cell Stem Cell. 2010 July (7):20-24. DOI 10.1016/j.stem.2010.06.002.

Somers, A., Jean J.C., Sommer, C.A., Omari A., Ford, C.C., Mills, J.A., Ying, L., Gianotti Sommer, A., Jean, J.M., Smith, B.W., Lafyatis, R., Demierre, M.F., Weiss, D.J., French, D.L., Gadue, P., Murphy, G.J., Mostoslavsky, G., Kotton, D.N. Generation of transgene-free lung disease-specific human iPS cells using a single excisable lentiviral stem cell cassette. Stem Cells. 2010 Oct;28(10):1728-1740. Epub August 16 2010.

Koh, K.P., Yabuuchi, A., Rao, S., Huang, Y., Cunniff, K., Nardone, J., Laiho, A., Tahiliani, M., Sommer, C.A., Mostoslavsky, G., Laheesmaa, R., Orkin, S.H., Rodig, S.J., Daley, G.Q., and Rao, A. Tet1 and tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell. 2011 Feb 4;8(2):200-213.

Christodoulou, C., Longmire, T.A., Shen, S.S., Bourdon, A., Sommer, C.A., Gadue, P., Spira, A., Gouon-Evans, V., Murphy, G.J., Mostoslavsky, G.*, and Kotton, D.N.* Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes. Journal of Clinical Investigation. 2011 May 2. Pil:43853. Doi: 10.1172/JCI43853. Epub ahead of print. * Corresponding authors.

Mostoslavsky, G. The Magic Act of Generating Induced Pluripotent Stem Cells: Many Rabbits in the Hat. Stem Cells. 2012. Jan;30(1):28-32. Epub Sep 21 2011. doi: 10.1002/stem.742.

Farago, M., Rosenbluh, C., Tevlin, M., Fraenkel, S., Schlesinger, S., Masika, H., Gouzman, M., Teng, G., Schatz, D., Rais, Y., Hanna, J.H., Mildner, A., Jung, S., Mostoslavsky, G., Cedar, H., Bergman, Y. Clonal allelic predetermination of immunoglobulin-k rearrangement. Nature. 2012 Oct 25;490(7421):561-565. doi: 10.1038/nature11496. Epub 2012 Sep 30.

Lafaille, F.G., Pessach, I.M., Zhang, S.Y., Ciancanelli, M.J., Herman, M., Abhyankar, A., Ying, S.W., Keros, S., Goldstein, P.A., Mostoslavsky, G., Ordovas-Montanes, J., Jouanguy, E., Plancoulaine, S., Tu, E., Elkabetz, Y., Al-Muhsen, S., Tardieu, M., Schlaeger, T.M., Daley, G.Q., Abel, L., Casanova, J.L., Studer, L., Notarangelo, L.D.. Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells. Nature. 2012 Oct 28. Doi: 10.1038/nature11583.

Sommer, A.G., Rozelle, S.S., Sullivan, S., Mills, J.A., Park, S.M., Smith, B.W., Iyer, A.M., French, D.L., Kotton, D.N., Gadue, P., Murphy, G.J., Mostoslavsky, G. Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood Using the STEMCCA Lentiviral Vector. J Vis Exp. 2012 Oct 31;(68). doi:pii: 4327. 10.3791/4327.

Sommer, C.A., Christodoulou, C., Gianotti-Sommer, A., Shen, S.S., Sailaja, B.S., Hezroni, H., Spira, A., Meshorer, E., Kotton, D.N., Mostoslavsky, G. (2012) Residual Expression of Reprogramming Factors Affects the Transcriptional Program and Epigenetic Signatures of Induced Pluripotent Stem Cells. PLoS ONE 7(12): e51711. doi:10.1371/journal.pone.0051711. Epub 2012 Dec 14.

Smith, B.W., Rozelle, S.S., Leung, A., Ubellacker, J., Parks, A., Nah, S.K., French, D.L., Gadue, P., Monti, S., Chui, D.H., Steinberg, M.H., Frelinger, A.L., Michelson, A.D., Theberge, R., McComb, M.E. Costello, C.E., Kotton, D.N., Mostoslavsky, G., Sherr, D.H., Murphy, G.J. The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. Blood. 2013 Jul 18;122(3):376-385/blood-2012-11-466722. Epub 2013 May 30.

Leung, A., Nah, S.K., Reid, W., Ebata, A., Koch, C.M., Monti, S., Genereux, J.C., Wiseman, R.L., Wolozin, B., Connors, L.H., Berk, J.L., Seldin, D.C., Mostoslavsky, G., Kotton, D.N., Murphy, G.J. Induced Pluripotent Stem Cell Modeling of Multisystemic, Hereditary Transthyretin Amyloidosis. Stem Cell Reports. 2013 Oct 31;1(5):451-463. PMID:24286032

Sommer, C.A. and Mostoslavsky, G. RNA-Seq analysis of enteroendocrine cells reveals a role for FABP5 in the control of GIP secretion. Mol. Endocrinol. 2014 Nov;28(11):1855-1865. doi: 10.1210/me2014-1194. Epub 2014 Sep 30 PMID:25268051

Wilson, A.A., Ying, L., Liesa, M., Segeritz, C.P., Mills, J.A., Shen, S.S., Jean, J., Lonza, G.C., Liberti, D.C., Lang, A.H., Nazaire, J., Gower, A.C., Müeller, F.J., Mehta, P., Ordóñez, A., Lomas, D.A., Vallier, L., Murphy, G.J., Mostoslavsky, G., Spira, A., Shirihai, O.S., Ramirez, M.I., Gadue, P., Kotton, D.N. Emergence of a Stage-Dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-Deficient iPS Cells. Stem Cell Reports. 2015 May 12;4(5):873-85. doi: 10.1016/j.stemcr.2015.02.021. Epub 2015 Apr 2. PMID:25843048

Etchegaray, J.P., Chavez, L., Huang, Y., Ross, K.N., Choi, J., Martinez-Pastor, B., Walsh, R.M., Sommer, C.A., Lienhard, M., Gladden, A., Kugel, S., Silberman, D.M., Ramaswamy, S., Mostoslavsky, G., Hochedlinger, K., Goren, A., Rao, A., Mostoslavsky, R. The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine. Nat Cell Biol. 2015 May;17(5):545-57. doi: 10.1038/ncb3147. Epub 2015 Apr 27. PMID:25915124

Thomas, D.D., Sommer, A.G., Balazs, A.B., Beerman, I., Murphy, G.J., Rossi, D., Mostoslavsky, G. Insulin-like growth factor 2 (IGF2) modulates murine hematopoietic stem cell maintenance through upregulation of p57. Exp Hematol. 2016 Feb 9. pii: S0301-472X(16)00039-4. doi: 10.1016/j.exphem.2016.01.010. [Epub ahead of print] PMID:26872540

A full list of publications is available in PubMed.

Primary teaching affiliate
of BU School of Medicine