David C. Seldin, M.D., Ph.D.
Professor of Medicine and Microbiology
Director, Graduate Program in Molecular Medicine,
Chief, Section of Hematology-Oncology
650 Albany Street
Office; X426; 617-638-7027
Lab: X4; 617-638-7522
B.A. Harvard College
M.D.-Ph.D. Harvard Medical School/M.I.T. Program in Health, Science, & Technology
My laboratory has two areas of interest. The first is the molecular basis of cancer, in which we make use of transgenic and knockout mouse models to complement biochemical and cell biological studies of the role of serine-threonine kinases in cellular growth control. We study a kinase, protein kinase CK2 (casein kinase II), that can behave as an oncogene when expressed in a dysregulated fashion in cells  or in the mammary gland . CK2 regulates two important signaling pathways that control cellular proliferation and apoptosis; the Wnt/beta-catenin pathway  and the NFkappaB pathway. In addition to characterizing pathological situations in which CK2 dysregulation leads to cancer, we are using gene targeting technology to characterize the essential development roles of the isoforms of CK. Another area of research in the laboratory is focussed upon the disease systemic (AL) amyloidosis, in which clonal immunoglobulin light chains form fibrillar deposits in tissues leading to organ failure and death. We are cloning, sequencing and expressing patient amyloidogenic light chains to develop animal models for this disease .
- Xu X, Toselli PA, Russell LD, Seldin DC. 1999. Globozoospermia in mice lacking the protein kinase CK2alpha’ catalytic subunit. Nature Genetics. 23;118-121.
- Landesman-Bollag E, Romieu-Mourez R, Song D, Sonenshein GE, Cardiff RD, Seldin DC. 2001. Protein Kinase CK2 in Mammary Gland Tumorigenesis. Oncogene. 20:3247-3257.
- Dominguez I, Mizuno J, Wu H, Song D, Symes K, and Seldin DC. 2004. Protein Kinase CK2 is Required for Dorsal Axis Formation in Xenopus Embryos. Dev. Biol. 274(1):110-124.
- Lou DY, Dominguez I, Toselli P, Landesman-Bollag E, O’Brien C, and Seldin DC. 2008. The Alpha Catalytic Subunit Of Protein Kinase CK2 Is Required For Mouse Embryonic Development. Mol. Cell. Biol. 28(1):131-139.
- Ward JE, Brenner DA, Eberhard J, Liao R, Connors LH, O’Hara C, and Seldin DC. In vitro and in vivo mouse models for AL amyloidosis. In: Amyloid and Amyloidosis, Ed by G Grateau, RA Kyle, M Skinner. CRC Press, Boca Raton, pp 64-66, 2004.
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