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Barbara S. Nikolajczyk, Ph.D.

Associate Professor of Microbiology
72 East Concord Street
Office: L516A; 617-638-7019
Lab: L516; 617-638-7164
bnikol@bu.edu

B.S.    The Ohio State University, Columbus, Ohio
Ph.D.  The University of North Carolina at Chapel Hill

BN Lab 2015

The Nikolajczyk lab reported the first B cell and T cell functional analyses from type 2 diabetes patients and has since identified roles for lymphocyte-associated changes in disease pathogenesis. Lab focus also includes inflammatory complications of type 2 diabetes such as cardiovascular and periodontal disease. The lab complements analyses of human cells with whole animal models of obesity and type 2 diabetes. We anticipate this combination of ” bench to bedside” and “bedside to bench” approaches will move lab-derived insights to the clinic over the short term.

Representative Publications

  1. Ip, B, Belkina, AC, DeFuria, J, Jagannathan-Bogdan, M, Hasson, B, Kuchibhatla, R, McDonnell, ME, Abovian, CM, Istfan, N, Xiao, Q, Kepler, TB, and Nikolajczyk, BS. 2015. B cells support a dominant TH17 cytokine signature in type 2 diabetes. (in press).
  2. Zhu M, Nikolajczyk BS. 2014. Immune cells link obesity-associated type 2 diabetes and periodontitis. J Dent Res. 93:346-52. PMID: 24393706.
  3. Zhu M, Belkina AC, Defuria J, Carr JD, Van Dyke TE, Gyurko R, Nikolajczyk BS. 2014. B cells promote obesity-associated periodontitis and oral pathogen-associated inflammation. J. Leukoc. Biol. [Epub ahead of print]. PMID: 24782490.
  4. Strissel, KJ, Denis, GV, and Nikolajczyk, BS. 2014. Immune regulators of inflammation in obesity-associated type 2 diabetes and coronary artery disease. Curr. Opin. Endocrinol. Diabetes Obesity 21(5):330-338. PMID: 25106001.
  5. DeFuria, J, Belkina, AC, Jagannathan-Bogdan, M, Snyder-Cappione, J, Carr, JD, Nersesova, Y, Markham, D, Strissel, KJ, Watkins, A, Allen, J, Bouchard, J, Torald, G, Jasuja, R, Obin, MS, McDonnell, ME, Apovian, C, Denis, GV and Nikolajczyk, BS. 2013. B cells promote inflammation in obesity and type 2 diabetes through regulation of T cell function and an inflammatory cytokine profile. Proc. Natl. Acad. Sci. USA 110:5133-5138, 2013. PMID: 23479618.
  6. Belkina, AC, Nikolajczyk, BS, Denis, GV. 2013. BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses. J. Immunol. 190:3670-8. PMID: 23420887.
  7. Nikolajczyk, BS, Jagannathan-Bogdan, M, Denis, G. 2012. The Outliers become a Stampede as Immunometabolism Reaches a Tipping Point. Immunol. Rev. 249:253-275. PMID 22889227.
  8. Jagannathan-Bogdan, M, McDonnell, ME, Shin, H, Rehman, Q, Hasturk, H, Apovian, CM, and Nikolajczyk, BS. 2011. Elevated pro-inflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in T2D. J. Immunol. 186:1162-172. PMID: 21169542
  9. Ganley-Leal, LM, Liang, YM, Jagannathan-Bogdan, M, Farraye, FA and Nikolajczyk, BS. 2010. Differential regulation of TLR4 expression in human B cells and monocytes. Mol. Immunol. 48:82-88. PMID: 20956019
  10. Nikolajczyk, BS. 2010. B cells as unappreciated mediators of human non-autoimmune inflammatory disease. Cytokine 50:234-242. PMID: 20382544
  11. Jagannathan, M, McDonnell, ME, Liang, Y, Hasturk, H, Hetzel, JT, Rubin, D, Kantarci, A, Van Dyke, TE, Ganley-Leal, LM, and Nikolajczyk, BS. 2010. Toll-like receptors regulate B cell cytokine production in patients with diabetes. Diabetologia 53:1461-1471. PMID: 20383694
  12. Jagannathan, M, Hasturk, H, Liang, Y, Shin, H, Hetzel, JT, Kantarci, A, Rubin, D, McDonnell, ME, Van Dyke, TE, Ganley-Leal, LM, and Nikolajczyk, BS. 2009. TLR cross-talk specifically regulates cytokine production by B cells from chronic inflammatory disease patients. J. Immunol. 183:7461-7470. PMID: 19917698
  13. Noronha, AM, Liang, Y, Hetzel, JT, Hasturk, H, Kantarci, A, Stucchi, A, Zhang, Y, Nikolajczyk, BS, Farraye, FA, and Ganley-Leal, LM. 2009. Hyperactivated B cells in human inflammatory bowel disease. J. Leuk. Biol. 86:1007-1016. PMID19589946
  14. *Shin, H, *Zhang, Y, Jagannathan, M, Hasturk, H, Kantarci, A, Liu, H, Van Dyke, TE, Ganley-Leal, LM and Nikolajczyk, BS. 2009. B cells from periodontal disease patients express surface Toll-like Receptor 4. J. Leuk. Biol. 85:648-655.  *equal contribution. PMID: 19118102
  15. Zhang, Y, Saccani, S, Shin, H and Nikolajczyk, BS. 2008. Dynamic protein associations define two phases of IL-1beta transcriptional activation. J. Immunol. 181:503-512. PMID: 18566416

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Primary teaching affiliate
of BU School of Medicine