Emergency BU Alert BU Medical Campus OPEN Jan. 28, 2015 Boston University Medical Campus will be open Wednesday, Jan. 28, 2015. BUSM classes will be held as scheduled. Staff should check with their managers regarding work schedules. Medical, PA and GMS students who are assigned to inpatient services or clinics are expected to be present, if possible. Students who are assigned to outpatient services should check with their course director or the policy at the clinical site. GMS classes are canceled. Staff should check with their manager regarding their work schedules. The Henry M. Goldman School of Dental Medicine will follow normal school hours. All Patient Treatment Centers will be open for patient care and all classes will be held as scheduled. BU School of Public Health classes are canceled; SPH non-essential staff may telecommute. Employees who are part of the BUMC parking program should park in your assigned lot or garage. The Boston parking ban is still in effect. For updated information, please call the weather/emergency hotline at 617-638-6886 or visit the BU Emergency Communications website at http://www.bu.edu/ehs/comm/

Barbara S. Nikolajczyk, Ph.D.

Associate Professor of Microbiology
72 East Concord Street
Office: L516A; 617-638-7019
Lab: L516; 617-638-7164
bnikol@bu.edu

B.S.    The Ohio State University, Columbus, Ohio
Ph.D.  The University of North Carolina at Chapel Hill

graduation-2226

The Nikolajczyk lab reported the first B cell and T cell functional analyses from type 2 diabetes patients and has since identified roles for lymphocyte-associated changes in disease pathogenesis. Lab focus also includes inflammatory complications of type 2 diabetes such as cardiovascular and periodontal disease. The lab complements analyses of human cells with whole animal models of obesity and type 2 diabetes. We anticipate this combination of ” bench to bedside” and “bedside to bench” approaches will move lab-derived insights to the clinic over the short term.

Representative Publications

  1. Zhang, Y., S. Saccani, H. Shin, and B.S. Nikolajczyk. 2008. Dynamic protein associations define two phases of IL-1beta transcriptional activation. J. Immunol. 181:503-512. PMID: 18566416
  2. *Shin, H., Y. *Zhang, M. Jagannathan, H. Hasturk, A. Kantarci, H. Liu, T.E. Van Dyke, L.M. Ganley-Leal, and B.S. Nikolajczyk. 2009. B cells from periodontal disease patients express surface Toll-like Receptor 4. J. Leuk. Biol. 85:648-655.  *equal contribution. PMID: 19118102
  3. Noronha, A.M., Y. Liang, J.T. Hetzel, H. Hasturk, A. Kantarci, A Stucchi, Y. Zhang, B.S. Nikolajczyk, F.A. Farraye, and L.M. Ganley-Leal. 2009. Hyperactivated B cells in human inflammatory bowel disease. J. Leuk. Biol. 86:1007-1016. PMID19589946
  4. Jagannathan, M., H. Hasturk, Y. Liang, H. Shin, J.T. Hetzel, A. Kantarci, D. Rubin, M.E. McDonnell, T.E. Van Dyke, L.M. Ganley-Leal, and B.S. Nikolajczyk. 2009. TLR cross-talk specifically regulates cytokine production by B cells from chronic inflammatory disease patients. J. Immunol. 183:7461-7470. PMID: 19917698
  5. Jagannathan, M., M.E. McDonnell, Y. Liang, H. Hasturk, J.T. Hetzel, D. Rubin, A. Kantarci, T.E. Van Dyke, L.M. Ganley-Leal, and B.S. Nikolajczyk. 2010. Toll-like receptors regulate B cell cytokine production in patients with diabetes. Diabetologia 53:1461-1471. PMID: 20383694
  6. Nikolajczyk, B.S. 2010. B cells as unappreciated mediators of human non-autoimmune inflammatory disease. Cytokine 50:234-242. PMID: 20382544
  7. Ganley-Leal, LM, Liang, YM, Jagannathan-Bogdan, M, Farraye, FA and Nikolajczyk, BS. 2010. Differential regulation of TLR4 expression in human B cells and monocytes. Mol. Immunol. 48:82-88. PMID: 20956019
  8. Jagannathan-Bogdan, M, McDonnell, ME, Shin, H, Rehman, Q, Hasturk, H, Apovian, CM, and Nikolajczyk, BS. 2011. Elevated pro-inflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in T2D. J. Immunol. 186:1162-172. PMID: 21169542
  9. Nikolajczyk, BS, Jagannathan-Bogdan, M, Denis, G. 2012. The Outliers become a Stampede as Immunometabolism Reaches a Tipping Point. Immunol. Rev. 249:253-275. PMID 22889227.
  10. Belkina, AC, Nikolajczyk, BS, Denis, GV. 2013. BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses. J. Immunol. 190:3670-8. PMID: 23420887.
  11. DeFuria, J, Belkina, AC, Jagannathan-Bogdan, M, Snyder-Cappione, J, Carr, JD, Nersesova, Y, Markham, D, Strissel, KJ, Watkins, A, Allen, J, Bouchard, J, Torald, G, Jasuja, R, Obin, MS, McDonnell, ME, Apovian, C, Denis, GV and Nikolajczyk, BS. B cells promote inflammation in obesity and type 2 diabetes through regulation of T cell function and an inflammatory cytokine profile. Proc. Natl. Acad. Sci. USA 110:5133-5138, 2013. PMID: 23479618.
  12. Zhu M, Belkina AC, Defuria J, Carr JD, Van Dyke TE, Gyurko R, Nikolajczyk BS. 2014. B cells promote obesity-associated periodontitis and oral pathogen-associated inflammation. J. Leukoc. Biol. [Epub ahead of print]. PMID: 24782490.
  13. Zhu M, Nikolajczyk BS. 2014. Immune cells link obesity-associated type 2 diabetes and periodontitis. J Dent Res. 93:346-52. PMID: 24393706.

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Primary teaching affiliate
of BU School of Medicine