Vanessa Xanthakis, Ph.D.

Assistant Professor of MedicineVanessa_Xanthakis


B.S. National and Kapodistrial University of Athens, Greece
M.S. (US equiv.) National and Kapodistrial University of Athens, Greece
Ph.D. Boston University

General field of research:

Cardiovascular Epidemiology

Affiliations other than medicine:

Department of Biostatistics,
Boston University School of Public Health

Contact information:

801 Massachusetts Avenue, Suite 470, Boston MA 02118

(617) 638-8016

(617) 638-8076



Preventive Medicine, Biostatistics, Cardiovascular Epidemiology

Recent publications:

  1. Xanthakis V, Enserro D, Murabito JM, Polak JF, Wollert KC, Januzzi JL, Wang TJ, Toffler G, Vasan RS. “Ideal cardiovascular health: associations with biomarkers and subclinical disease, and impact on incidence of cardiovascular disease in the Framingham Offspring Study”, Circulation 2014 PMID: 25274000
  2. Xanthakis V, Sullivan LM, Vasan RS, Benjamin EJ, Massaro JM, D’Agostino Ralph B, Pencina MJ. “Assessing the incremental predictive performance of novel biomarkers over standard predictors” Stat Med 2014, PMID:24719270
  3. Cheng S, Enserro D, Xanthakis V, Sullivan LM, Murabito JM, Benjamin EJ, Polak JF, O’Donnell CJ, Wolf PA, O’Connor GT, Keaney Jr. JF, Vasan RS. “Association of Exhaled Carbon Monoxide with Subclinical Cardiovascular Disease and Their Conjoint Impact on the Incidence of Cardiovascular Outcomes” Eur Heart J PMID: 24574370
  4. Xanthakis V, Larson MG, Wollert KC, Aragam J, Cheng S, Ho J, Coglianese E, Levy D, Colucci WS, Felker GM, Benjamin EJ, Januzzi JL, Wang TJ, Vasan RS. “Association of Novel Biomarkers of Cardiovascular Stress with Left Ventricular Hypertrophy and Dysfunction: implications for screening”. J Am Heart Assoc, 2013. PMID: 24200688
  5. Xanthakis V, Sullivan LM, Vasan RS. “Multilevel modeling versus cross-sectional analysis for assessing the longitudinal tracking of cardiovascular risk factors over time”. Stat Med. 2013 PMID: 23784950
  6. Musani SK, Vasan RS, Bidulescu A, Liu J, Xanthakis V, Sims M, Gawalapu RK, Samdarshi T, Steffes M, Taylor HA, Fox ER. “Aldosterone, C – reactive protein and Plasma B-Type Natriuretic Peptide are associated with the development of Metabolic Syndrome and Longitudinal Changes in Metabolic Syndrome Components: Findings from the Jackson Heart Study”. Diabetes Care PMID: 23757435
  7. Xanthakis V, Vasan RS. “Aldosterone and the Risk of Hypertension”. Curr Hypertens Rep. 2013; 15 (2):102-7. PMID: 23378101
  8. Cheng S, Xanthakis V, Sullivan LM, Vasan RS. “Blood Pressure Tracking Over the Adult Life Course: Patterns and Correlates in the Framingham Heart Study”. Hypertension. 2012 60 (6):1393-9. PMID: 23108660
  9. Xanthakis V, Vasan RS. “Improving cardiovascular health in women and children around the world”. Indian J Med Res. 2012; 136(3):359-61. PMID: 23041726
  10. Wang TJ, Wollert KC, Larson MG, Coglianese E, McCabe EL, Cheng S, Ho JE, Fradley MG, Ghorbani A, Xanthakis V, Kempf T, Benjamin EJ, Levy D, Vasan RS, Januzzi JL. “Prognostic Utility of Novel Biomarkers of Cardiovascular Stress: The Framingham Heart Study”. Circulation. 2012; 126 (13):1596-604. PMID: 22907935
  11. Haring R, Teng Z, Xanthakis V, Coviello A, Sullivan L, Bhasin S, Murabito JM, Wallaschofski H, Vasan RS.Association of sex steroids, gonadotropins, and their trajectories with clinical cardiovascular disease and all-cause mortality in elderly men from the Framingham Heart Study”. Clin Endocrinol (Oxf). 2012;78 (4):629-34. PMID: 22901104
  12. Kaess BM, Enserro DM, McManus DD, Xanthakis V, Chen MH, Sullivan LM, Ingram C, O’Donnell CJ, Keaney JF, Vasan RS, Glazer NL. “Cardiometabolic Correlates and Heritability of Fetuin-A, Retinol-Binding Protein 4 and Fatty-Acid Binding Protein 4 in the Framingham Heart Study”. J Clin Endocrinol Metab. 2012; 97 (10):e1943-7. PMID: 22855337
  13. Haring R, Xanthakis V, Coviello A, Sullivan L, Bhasin S, Wallaschofski H, Murabito JM, Vasan RS. “Clinical correlates of sex steroids and gonadotropins in men over the late adulthood: the Framingham Heart Study”. Int J Androl. 2012;35 (6): 775-82; PMID: 22640232
  14. Zachariah JP, Xanthakis V, Larson MG, Vita JA, Sullivan LM, Smith HM, Safa R, Peng X, Hamburg N, Levy D, Sawyer DB, Mitchell GF, Vasan RS. “Circulating Vascular Growth Factors and Central Hemodynamic Load in the Community”. Hypertension. 2012; 59 (4):773-9; PMID: 22371357
  15. Debette S, Visvikis-Siest S, Chen MH, Ndiaye NC, Song C, Destefano A, Safa R, Azimi Nezhad M, Sawyer D, Marteau JB, Xanthakis V, Siest G, Sullivan L, Pfister M, Smith H, Choi SH, Lamont J, Lind L, Yang Q, Fitzgerald P, Ingelsson E, Vasan RS, Seshadri S. “Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels”. Circulation Research. 2011;109(5):554-63. PMID: 21757650.
  16. Lüneburg N, Xanthakis V, Schwedhelm E, Sullivan LM, Maas R, Anderssohn M, Riederer U, Glazer NL, Vasan RS, Böger RH. Reference intervals for plasma-L-arginine and the L-arginine/ADMA ratio in the Framingham Offspring Cohort, in press Journal of Nutrition 2011;141 (12):2186-90. PMID: 22031661.
  17. Schwedhelm E, Xanthakis V, Maas R, Sullivan LM, Atzler D, Lüneburg N, Glazer NL, Riederer U, Vasan RS, Böger RH. “Plasma symmetric dimethylarginine reference limits from the Framingham offspring cohort”. Clinical Chemistry and Laboratory Medicine. 2011; 49 (11): 1907-10. PMID: 21864208
  18. Lam CS, Xanthakis V, Sullivan LM, Lieb W, Aragam J, Redfield MM, Mitchell GF, Benjamin EJ, Vasan RS. “Aortic root remodeling over the adult life course: longitudinal data from the Framingham Heart Study”. Circulation. 2010, PMID:20713896
  19. Cheng S, Xanthakis V, Sullivan LM, Lieb W, Massaro J, Aragam J, Benjamin EJ, Vasan RS. “Correlates of echocardiographic indices of cardiac remodeling over the adult life course: longitudinal observations from the Framingham Heart Study”. Circulation. 2010; PMID: 20660804
  20. Lam CS, Chen MH, Lacey SM, Yang Q, Sullivan LM, Xanthakis V, Safa R, Smith HM, Peng X, Sawyer DB, Vasan RS. “Circulating insulin-like growth factor-1 and its binding protein-3: metabolic and genetic correlates in the community”. Arteriosclerosis, Thrombosis, and Vascular Biology, 2010; PMID: 20378848
  21. Lieb W, Zachariah JP, Xanthakis V, Safa R, Chen MH, Sullivan LM, Larson MG, Smith HM, Yang Q, Mitchell GF, Vita JA, Sawyer DB, Vasan RS. “Clinical and genetic correlates of circulating angiopoietin-2 and soluble Tie-2 in the community”. Circulation: Cardiovascular Genetics, 2010; 3(3):300-6. PMID: 20348331
  22. McManus DD, Xanthakis V, Sullivan LM, Zachariah J, Aragam J, Larson MG, Benjamin EJ, Vasan RS. “Longitudinal tracking of left atrial diameter over the adult life course: Clinical correlates in the community”. Circulation. 2010; 121(5):667-74. PMID: 20100973
  23. Schwedhelm E, Xanthakis V, Maas R, Sullivan LM, Schulze F, Riederer U, Benndorf RA, Böger RH, Vasan RS. “Asymmetric dimethylarginine reference intervals determined with liquid chromatography-tandem mass spectrometry: results from the Framingham offspring cohort”. Clinical Chemistry, 2009; 55(8):1539-45. PMID:19541865
  24. Lieb W, Xanthakis V, Sullivan LM, Aragam J, Pencina MJ, Larson MG, Benjamin EJ, Vasan RS. “Longitudinal tracking of left ventricular mass over the adult life course: clinical correlates of short- and long-term change in the Framingham Offspring Study”. Circulation. 2009; 119(24):3085-92. PMID: 19506113
  25. Maas R, Xanthakis V, Polak JF, Schwedhelm E, Sullivan LM, Benndorf R, Schulze F, Vasan RS, Wolf PA, Böger RH, Seshadri S. “Associaton of the endogenous nitric oxide synthase inhibitor ADMA with carotid artery intimal media thickness in the Framingham Heart Study Offspring cohort”. Stroke. 2009; 40(8):2715-9. PMID: 19498184
  26. Böger RH, Sullivan LM, Schwedhelm E, Wang TJ, Maas R, Benjamin EJ, Schulze F, Xanthakis V, Benndorf RA, Vasan RS. “Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community”. Circulation. 2009; 119(12):1592-600. PMID: 19289633
  27. Lieb W, Safa R, Benjamin EJ, Xanthakis V, Yin X, Sullivan LM, Larson MG, Smith HM, Vita JA, Mitchell GF, Sawyer DB, Vasan RS. “Vascular endothelial growth factor, its soluble receptor, and hepatocyte growth factor: clinical and genetic correlates and association with vascular function”. Eur Heart J, 2009; 30(9):1121-7. Erratum in: Eur Heart J, 2010; 31(20):2557. PMID: 19223316
  28. Lieb W, Benndorf RA, Benjamin EJ, Sullivan LM, Maas R, Xanthakis V, Schwedhelm E, Aragam J, Schulze F, Böger RH, Vasan RS. “Plasma asymmetric dimethylarginine, L-arginine and left ventricular structure and function in a community-based sample”. Atherosclerosis. 2009; 204(1):282-7. PMID: 18829028