XiaoYong Tong

Assistant Professor of Medicine

Education:

PhD of Pharmacology Peking Union Medical College, Beijing, China

General Field of Work:

Cardiovascular and Diabetic fields

Affiliations other than medicine:

Evans Center for Interdisciplinary Biomedical Research

Contact information:

Office:
650 Albany street, X729

Office Telephone:
6174141009

Lab Telephone:
6176387116

Fax number:
6176387113

Email:
xytong@bu.edu

Keywords:

atherosclerosis; angiogenesis; restenosis, SERCA; Nitric oxide; NADPH oxidase

Summary of academic interest:

Diabetic patients have much higher morbidity and mortality of cardiovascular diseases including atherosclerosis and restenosis compared with other populations. Vascular smooth muscle cell (SMC) migration contributes significantly to these pathological processes. Generally SMCs stay quiescent in vasculature. When the endothelium layer is disrupted, the underlying SMCs migrate from media to intima and form the neointima. This process is accelerated in diabetes mellitus (DM). Nitric oxide (NO), the biologically active component of endothelium-derived relaxing factor, has critical roles in the maintenance of vascular homeostasis. Previous studies showed that NO reduces intracellular calcium, which causes relaxation and inhibits SMC growth and proliferation in native smooth muscle. Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) plays a very important role in maintaining intracellular calcium level by uptaking calcium into SR/ER. Our previous studies s! howed that NO upregulated SERCA activity by S-glutathiolation of the most reactive thiol on cysteine-674 (C674) and inhibited SMC migration. My major focus is to study the mechanisms of cardiovascular dysfunction in diabetes, mainly focus on SERCA, NADPH oxidase and smooth muscle cell migration. Those studies can also be expanded to obesity, insulin resistance and metabolic symptoms.

Recent Publications:

1. Tong XY, Porter LM, Liu G, Dhar-Chowdhury P, Srivastava S, Pountnery DJ, Yoshida H, Artman M, Fishman GI, Yu C, Iyer R, Morley GE, Gustein DE, Coetzee WA (2006). Consequences of cardiac myocyte-specific ablation of KATP channels in transgenic mice expressing dominant negative Kir6 subunits. Am J Physiol Heart Circ Physiol. 291 (2): H543-51. PMID: 16501027

2. Malester B*, Tong XY*, Ghui I, Xu J, Hendricks-Munoz KD and Coetzee WA (2007) Transgenic disruption of endothelial KATP channels in the mouse: effects on coronary flow mediated by altered endothelin-1 release. FASEB J. 21(9):2162-72. (Co-first author) PMID: 17341678

3. Ying J, Tong XY, Pimental D, Weisbrod R, Trucillo MP, Adachi T, Cohen R (2007). Cysteine-674 of the sarco/endoplasmic reticulum calcium ATPase is required for the inhibition of cell migration by nitric oxide. Arterioscler Thromb Vasc Biol. 27(4):783-90. PMID: 17234728

4. Tong XY*, Ying J, Pimentel DR, Trucillo M, Adachi T, Cohen RA (2008). High glucose oxidizes SERCA cysteine-674 and prevents inhibition by nitric oxide of smooth muscle cell migration. J Mol Cell Cardiol. 44: 361-369. (corresponding author) PMID: 18164028

5. Tong XY* and Schröder K (2009). NADPH oxidases are responsible for the failure of nitric oxide to inhibit migration of smooth muscle cells exposed to high glucose. Free Radical Bio Med. 47(11):1578-83. (corresponding author) PMID: 19733235

6. Tong XY*, Hou X, Jourd’heuil D, Weisbrod RM, Pimentel DR, Cohen RA (2010). Upregulation of Nox4 by TGF beta1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat. Cir Res.107 (8):975-83. (corresponding author) PMID: 20724704

7. Cohen RA and Tong XY*. (2010). Vascular oxidative stress: the common link in hypertensive and diabetic vascular disease. J Cardiovascu Pharmacol. 55(4):308-16. (Invited review, corresponding author) PMID: 20422735

8. Tong XY*, Evangelista A, Cohen RA (2010). Targeting the redox regulation of SERCA in vascular physiology and disease. Curr Opin Pharmacol. 10(2):133-8. (Invited review, corresponding author) PMID: 20045379