Katrina Steiling

Assistant Professor of Medicine

Education:Steiling_Katrina-2-5x3-5

Bachelor of Science, Boston College, Chestnut Hill, MA
Doctorate in Medicine, Boston University School of Medicine, Boston, MA
Internship and Residency in Internal Medicine, Boston University Medical Center, Boston, MA
Postdoctoral Research Fellowship, The Pulmonary Center, Boston University Medical Center, Boston MA
Pulmonary/Critical Care Fellowship, Boston University Medical Center, Boston, MA
Masters of Science (Bioinformatics), College of Engineering, Boston University, Boston, MA

Board Certifications: Internal Medicine, Pulmonary Disease, Critical Care Medicine

Other websites:

www.pulmonomics.org

General Field of Work:

Bioinformatics

Affiliations other than medicine:

Division of Computational Biomedicine
The Pulmonary Center
Center for Thoracic Oncology

Contact information:

Office:  72 East Concord Street, R-304
Lab:  72 East Concord Street, Evans 631
Office Telephone:  (617)-414-6996
Lab Telephone:  (617)-414-7050
Fax:  (617)-414-6999
Email: steiling@bu.edu

Keywords:

bioinformatics
gene expression
copd
lung cancer
cigarette smoking

Summary of academic interest:

Dr. Steiling’s research focuses on applying high-throughput genomic tools and emerging computational methods to develop improved diagnostics, prognostics, and risk stratification tools for phenotypically complex lung diseases such as COPD and lung cancer. Dr. Steiling’s primary research involves gene expression profiling of the airway epithelium from individuals with COPD in order to understand the molecular mechanisms of this disease and its relationship to lung cancer. She has also worked to apply airway gene expression profiling to the diagnosis of lung cancer, to understand the relationship between smoking-induced changes in gene expression in the bronchial airway and the upper airway, and to elucidate the relationship between smoking-induced changes in airway gene and protein expression.

Recent Publications:

Gower AC, Steiling K, Brothers JF, Lenburg ME, Spira A. “Transcriptomic
studies of the airway ‘field of injury’ associated with smoking-related lung
disease.” Proc Am Thorac Soc, 2011; 8(2):173-179.

Brody JS, Steiling K. “Interaction of cigarette exposure and airway epithelial
cell gene expression” Annu Rev Physiol. 2011; 73:437-456.

Spira A, Steiling K. Topics in genetics and genomics: Gene Expression.
In: UpToDate, Basow DS (Ed), UpToDate, Waltham, MA, 2010.

Steiling K, Lenberg ME, Spira A. “Airway Gene Expression in Chronic Obstructive Pulmonary Disease.” Proc Am Thorac Soc. 2009;6:697-700.

Steiling K, Kadar AY, Bergerate A, Flanigon J, Sridhar S, Shah V, Ahmad QR, Brody JS, Lenburg ME, Steffen M, Spira A. “Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokers.” PLoS ONE. 2009;4(4):e5043.

Steiling K, Ryan J, Brody JS*, Spira A*. “The field of tissue injury in the lung and airway.” Cancer Prevention Research, 2008; 1(6):396-403. *contributed equally as senior author

Beane J, Sebastiani P, Whitfield TH, Steiling K, Dumas YM, Lenburg ME, Spira A. “A prediction model for lung cancer diagnosis that integrates genomic and clinical features.” Cancer Prevention Research, 2008; 1:56-64.

Spira A, Beane JE, Shah V, Steiling K, Liu G, Schembri F, Gilman S, Dumas YM, Calner P, Sebastiani P, Sridhar S, Beamis J, Lamb C, Anderson T, Gerry N, Keane J, Lenburg ME, Brody JS. “Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer.” Nature Medicine, 2007; 13(3):361-6.