Marie E. McDonnell

Assistant Professor of Medicine

Education:MEM in office

MD 5/23/1999 Boston University School of Medicine Boston, MA
BA 5/8/1994 College of the Holy Cross Worcester, MA
New York Presbyterian Hospital-Columbia Campus Post Graduate Resident New York, NY 6/26/99-5/7/2002
New York Presbyterian Hospital-Columbia Campus Chief Medical Resident New York, NY 5/8/2002-5/22/2003
Boston University – Boston Medical Center Post Graduate Fellow in Endocrinology Boston, MA 7/1/2003-6/30/2005

General Field of Work:

Endocrinology, Diabetes and Metabolism

Affiliations other than medicine:

Assistant Professor in Medicine Boston University School of Medicine, Boston, MA 7/1/2006- present
Instructor in Medicine Boston University School of Medicine, Boston, MA 1/01/2005 – 6/30/2006
Clinical Teaching Fellow Boston University School of Medicine, Boston, MA 7/1/2003-6/30/2005
Instructor in Medicine College of Physicians & Surgeons, Columbia University, New York, NY 5/8/2002-5/22/2003
Attending Physician, Section of Endocrinology
Boston University School of Medicine, Boston, MA1/01/2005-pres.
Assistant Attending Physician College of Physicians & Surgeons, Columbia University, New York, NY 5/8/2002-5/22/2003

Contact information:

Office and Lab:  Evans 256
Phone: (617)-638-8533
marie.mcdonnell@bmc.org

Keywords:

Inpatient Diabetes
Obesity-related type 2 diabetes
Inflammation
Adipocyte immunology

Summary of academic interest:idp

The research interests of Dr. McDonnell include two distinct areas, 1) the management and global care of the patient with diabetes admitted to the hospital and 2) the underlying mechanisms explaining the pathophysiologic links between obesity and type 2 diabetes.

In the area of inpatient diabetes, I am leading our team in the development of a large database for the purpose of designing risk/benefit strategies for insulin dosing. This includes patient-tailored insulin therapy and transitions of care as priorities. Interventions being studied currently include a diabetes rapid follow-up program for patients presenting to the Emergency Room/Urgent care, and the Newly Identified Diabetes Nursing Pathway, which incorporates resource allocation and standardized low-literacy bedside education into a structured inpatient stay for our patients with new diabetes.

Additionally I participate in a multidisciplinary research program to investigate the immunologic aspects of chronic inflammation in obesity-related type 2 diabetes, which relates not only to the development of the disease from insulin resistant pre-diabetic states, but to the progression of serious complications, such as cardiovascular disease. I have co-developed adipose tissue biopsy techniques within the Obesity research group here at BMC. This research group has been active in the area of inflammation, adipose tissue immunology and insulin resistance, and we have been able to associate the presence of organized groups of adipose tissue macrophages with systemic insulin resistance and vascular reactivity in humans. Other overlapping collaborations with researchers in microbiology and immunology have allowed me to investigate the role of circulating immune cells in the modulation of chronic inflammation in type 2 diabetes, and how other factors, such as bacteria and thei! r products, may add to the fascinating interplay between lymphocytes, monocytes and adipocytes.

Recent Publications:

Inpatient Diabetes

Pietras SM, Hanrahan P, Arnold LM, Sternthal E, McDonnell ME. State-of-the-art inpatient diabetes care: The evolution of an academic hospital. Endocr Pract. 2010 Mar 29:1-28. PMID: 20350921.

Rubin DJ, Rybin D, Doros G, McDonnell ME. Weight-based, insulin dose-related hypoglycemia in hospitalized patients with diabetes. Diabetes Care. 2011 Aug;34(8):1723-8. Epub 2011 Jun 23. PubMed PMID: 21700919.

Lazar HL, McDonnell M, Chipkin SR, Furnary AP, Engelman RM, Sadhu AR, Bridges CR, Haan CK, Svedjeholm R, Taegtmeyer H, Shemin RJ; Society of Thoracic Surgeons Blood Glucose Guideline Task Force. The Society of Thoracic Surgeons practice guideline series: Blood glucose management during adult cardiac surgery Ann Thorac Surg. 2009 Feb;87(2):663-9.

Lazar HL, McDonnell ME, Chipkin S,Fitzgerald C, Bliss C, Cabral H. Effects of aggressive versus moderate glycemic control on clinical outcomes in diabetic coronary artery bypass graft patients. Annals of Surgery. In Press

Obesity and Inflammation

Apovian CM, Bigornia S, Mott M, Meyers MR, Ullor J, Gagua M, McDonnell ME, Hess D, Joseph L, Gokce, N. Adipose Macrophage Infiltration is Associated with Insulin Resistance and Vascular Endothelial Dysfunction in Obese Subjects. Arteriosclerosis, Thrombosis, and Vascular Biology. 2008 Jun; 28:1654-1659.

McDonnell ME, Liang Y, Noronha A, Coukos J, Kasper DL, Farraye FA, Ganley-Leal LM. Systemic Toll-like receptor ligands modify B-cell responses in human inflammatory bowel disease. Inflamm Bowel Dis. 2011 Jan;17(1):298-307. PMID: 20806343.

Jagannathan-Bogdan M, McDonnell ME, Shin H, Rehman Q, Hasturk H, Apovian CM, Nikolajczyk BS. Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes. J Immunol. 2011 Jan 15;186(2):1162-72. PMID: 21169542

Jagannathan M, McDonnell M, Liang Y, Hasturk H, Hetzel J, Rubin D, Kantarci A,Van Dyke TE, Ganley-Leal LM, Nikolajczyk BS. Toll-like receptors regulate B cell cytokine production in patients with diabetes. Diabetologia. 2010 Jul;53(7):1461-71. Epub 2010 Apr 11. PubMed PMID: 20383694; PubMed Central PMCID:PMC2895399.