H. Christian Weber

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Assistant Professor of Medicine

Education:

MD; Hamburg University Schol of Medicine

General field of research:

Cancer; Obesity; Metabolism

Affiliations other than medicine:

Evans Center for Interdisciplinary Biomedical Research
Assistant Professor of Pathology and Laboratory Medicine

Contact information:

Office
EBRC Building, 5th floor, room 515
Phone: (617) 638-8330

Lab
EBRC Building, 5th floor, room 510
Phone: (617)-638 8346
Fax: (617)0638-7785

christian.weber@bmc.org

Research group information

Antonio d’Aiello
Ishita Deb Majumdar

Keywords:

Epithelial Cancer; Obesity; G protein-coupled Receptor Signaling; Fat Cell Metabolism; Regulatory Peptide GRP; GRP-receptor

Summary of research interest:

The major thrust of Dr. Weber’s laboratory focuses on cell and molecular biological studies of mammalian bombesin receptors in human cancer and obesity. This family of G protein-coupled receptors comprises the gastrin-releasing peptide receptor (GRP-R), the neuromedin B receptor (NMB-R), and the orphan bombesin receptor subtype-3 (BRS-3). The human GRP-R is found ectopically expressed in human cancers of the colon, stomach, and prostate thereby mediating potent mitogenic properties through ligand specific receptor activation. Our research is directed towards the understanding of molecular mechanisms of aberrant GRP-R expression in epithelial cells and intracellular signaling pathways relevant in GRP-R dependent cell proliferation. Furthermore, it has now been clearly established that GRP-R and BRS-3 play a significant role in the regulation of feeding behavior, obesity, and glucose homeostasis. Consequently, laboratory investigations are aimed
at the elucidation of ligand-activated intracellular signaling events and molecular mechanisms by which bombesin receptors regulate energy homeostasis.

Recent publications:

Xiao, D., Qu, X., and Weber, H.C. 2003. Activation of Extracellular Signal Regulated Kinase Mediates Bombesin-Induced Mitogenic responses in Prostate Cancer Cells. Cell Signalling 15 (10):945-953.

Qu, X., Xiao, D., and Weber, H.C. 2004. Transcriptional Activation of the Human Gastrin Releasing Peptide Receptor Gene in Gastrointestinal and Prostatic Epithelial Cancer Cells. J Mol Neuroscience 22: 75-82

Xiao, D., Chinnappan , D., Pestell, R., Albanese, C. and Weber, H. C. 2005. Bombesin Regulates Cyclin D1 Expression Through the Early Growth Response Protein EGR-1. Cancer Research 65 (21): 9934-9942

Tan YR, Qin XQ, Xiang Y, Yang T, Qu F, Wang Y, Liu HJ, Weber HC. 2007. PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells. Biochem J. 405(1):131-7.

Chinnappan, D., Qu, X., Xiao, D., Ratnasari, A. and Weber, H.C. 2008. Human Gastrin-Releasing Peptide Receptor Gene Regulation Requires Transcription Factor Binding at Two Distinct CRE Sites. Am J Physiol 295(1):G153-G162

Chinnappan, D., Xiao, D. Ratnasari, A., King, T., Andry, C. and H.C. Weber 2009. Transcription factor YY1 is over-expressed in gastrointestinal cancer cells. Int Journal Oncology (in press)

H. Christian Weber. 2009. Regulation and Signaling of Human Bombesin Receptors and Their Biological Effects. Current Opinions in Endocrinology, Diabetes & Obesity 16 (1): 66-71

Technologies available for sharing upon request:

PCR