Katya Ravid

Professor of Medicine and Biochemistry

Director, Evans Center for Interdisciplinary Biomedical Research

Scientific Director, BU Transgenic Core

Education:

DSc/PhD, Technion-Israel Institute of Technology

Post-Doc, Massachusetts Institute of Technology

General field of research:

Blood Stem Cells; Cardiovascular; Cell Cycle Control

Affiliations other than medicine:

Evans Center for Interdisciplinary Biomedical Research

Whitaker Cardiovascular Institute

Pharmacology and Experimental Therapeutics

Department of Biochemistry

Contact information:

Office

700 Albany Street, W-601

Boston, MA 02118

Phone: (617) 638-5053

Lab

700 Albany Street, W-500

Boston, MA 02118

Phone: (617) 638-5095

kravid@bu.edu

Other research websites:

http://www.bumc.bu.edu/exchweb/bin/redir.asp?URL=http://www.bumc.bu.edu/ravidlab/

http://www.bumc.bu.edu/transgenic

http://www.bumc.bu.edu/cardiograd

http://www.bu.edu/cores/cores/animal-research.html

http://www.bumc.bu.edu/medicine/evansbiomedicalresearch

Research group information:

Please visit: www.bumc.bu.edu/ravidlab

Keywords:

Megakaryocytes, Platelets, Stem Cells, Blood Cells, Thrombosis, Vascular Biology, Cell Cycle, Gene Expression

ravidtubulin

Staining of tubulin in a polyploid megakaryocyte (DJ. McCrann in Dr. Ravid’s lab)

Summary of research interest:

The cells of all blood lineages arise from pluripotent hematopoietic stem cells that reside in the marrow. The bone marrow also contains stem cells of other lineages, including fat, vascular etc. Our research is focused on two interrelated projects that bear on mechanisms associated with the development of blood and vascular pathologies: (1) molecular mechanisms involved in cell cycle control during the development of bone marrow megakaryocytes into platelets, a process that includes cellular polyploidization prior to platelet fragmentation. We also identified mechanisms of polyploidy in vascular smooth muscle cells, and found that the degree of polyploidy serves as an excellent biomarker for aging; (2) the role of vascular and bone marrow cell (progenitors and mature) adenosine receptors in vascular regeneration during injury or atherosclerosis. Transgenic and knockout models are used to assist in exploring mechanisms in vivo.

Selected publications:

For an updated list, please visit: www.bumc.bu.edu/ravidlab

Technologies available for sharing upon request:

Bone marrow cell isolation and culturing; immunostaining; atherosclerosis models; platelet function; megakaryocyte preparation; cell cycle control; ploidy analysis