Richard Near

Research Assistant Professor

Education:

PhD -Univ. Washington
Post Doc -MIT

General field of research:

Cell Signaling in Breast Cancer and Immune cells

Affiliations other than medicine:

Hematology/Oncology

Contact information:

Office
Dept Medicine, Heme/Onc EBRC X425
Phone: (617) 638 7529

rocket1@bu.edu

Keywords:

Breast Cancer; Signaling; Knockout mice; Eye Immunology

Summary of research interest:

We examine Breast Cancer signaling affecting antiestrogen resistance, morphology, invasiveness and metastesis. The gene family NSP is studied -in particular BCAR3/AND34. AND Knockout mice have been made with major lens developmental deformaties. BCAR3 is associated with focal adhesion signaling via the adapter protein p130CAS.

near_eye-phenotype2

Recent publications:

A, Near RI, Infusini G, Vanden Borre P, Bloom A, Cai D, Costello CE, Lerner A. 2009. AND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern. Makkinje Cell Signal. [Epub ahead of print] PMID: 19454314

Near RI, Smith RS, Toselli PA, Freddo TF, Bloom AB, Vanden Borre P, Seldin DC, Lerner A. 2009. Loss of AND-34/BCAR3 expression in mice results in rupture of the adult lens. Mol Vis. 15:685-99. Epub 2009 Apr 3.PMID: 19365570 [PubMed - in process]

Near RI, Zhang Y, Makkinje A, Vanden Borre P, Lerner A. J. 2007. AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. Cell Physiol. 212(3):655-65.PMID: 17427198 [PubMed - indexed for MEDLINE]
Near RI, Matulka RA, Mann KK, Gogate SU, Trombino AF, Sherr DH. 1999. Regulation of preB cell apoptosis by aryl hydrocarbon receptor/transcription factor-expressing stromal/adherent cells. Proc Soc Exp Biol Med. 221(3):242-52.PMID: 10404042 [PubMed - indexed for MEDLINE].

Near RI, Mudgett-Hunter M, Novotny J, Bruccoleri R, Ng SC. 1993. Characterization of an anti-digoxin antibody binding site by site-directed in vitro mutagenesis. Mol Immunol. 30(4):369-77. PMID: 8455637 [PubMed - indexed for MEDLINE]

Technologies available for sharing upon request:

Knockout mice; Cell Signaling