Richard H. Myers, PhD

Professor

Education:

PhD Georgia State University
Post Doc Emory University

General field of research:

Human Genetics

Affiliations other than medicine:

Evans Center for Interdisciplinary Biomedical Research
Neurology
Genome Science Institute
Bioinformatics
SPH Biostatistics
SPH Epidemiology
SPH Environmental Health

Contact information:

Office
E-304
Phone: (617) 638-5376

Lab
E-301
Phone: (617) 414-1202
Fax: (617) 638-5354

rmyers@bu.edu

Other research websites:

http://snp.bumc.bu.edu/ http://www.bumc.bu.edu/genetics/genetics-people/faculty/myers/

Research group information

Jemma B. Wilk DSc Assistant Professor
Jeanne Latourelle DSc Post-doc
Chris Pacheco PhD Post-doc
Audrey Hendricks BA Biostatistics Doctoral Student
Alexandra Dumitriu BS Bioinformatics Doctoral Student
Sally Williamson BS Laboratory Technician
Tiffany Massood MPH Study Coordinator

Keywords:

Human Genetics; Cardiovascular; Parkinson; Huntington

Summary of research interest:

My professional interests have focused upon the application of genetic research methods for the investigation of adult onset diseases with complex etiology (Parkinson’s disease, coronary heart disease, Alzheimer’s disease, pulmonary function, osteoarthritis, osteoporosis etc.). I have a long-standing interest in Huntington’s disease and have participated in a wide range of research investigations for this disease. I have been a member of the New England Huntington’s disease “Center Without Walls” since its inception in 1980. My HD studies may best be characterized as ‘Neurobiological Studies’ in that they include studies into the mechanisms of disease expression, including complex genetic modifier studies and a series of neuropathological studies of effects of disease expression in the brain. Additional interests are in the ethical issues influencing utilization of genetic test procedures.

I have been involved in a number of studies in positional cloning. I participated in the cloning of the gene for Huntington’s disease in 1993. I initiated the genome scan project in the Framingham Study, and a genome scan in Parkinson’s disease. My Parkinson’s disease genetic linkage study, known as the “GenePD” study, involves an international collaboration of twenty clinical centers in Parkinson’s disease. The study is seeking genetic loci involved in risk for PD. Since 1993 I have participated in genetic linkage studies for hypertension (the HyperGEN study, one of the NHLBI Family Blood Pressure Program Project studies), and the genome scan in the NHLBI Family Heart Study.

Recent publications:

Tobin JE, Latourelle JC, Lew MF, Klein C, Suchowersky O, Shill HA, Golbe LI, Mark MH, Growdon JH, Wooten GF, Racette BA, Perlmutter JS, Watts R, Guttman M, Baker KB, Goldwurm S, Pezzoli G, Singer C, Saint-Hilaire MH, Hendricks AE, Williamson S, Nagle MW, Wilk JB, Massood T, Laramie JM, DeStefano AL, Litvan I, Nicholson G, Corbett A, Isaacson S, Burn DJ, Chinnery PF, Pramstaller PP, Sherman S, Al-hinti J, Drasby E, Nance M, Moller AT, Ostergaard K, Roxburgh R, Snow B, Slevin JT, Cambi F, Gusella JF, Myers RH. 2008. Haplotypes and gene expression implicate the MAPT region for Parkinson disease: The GenePD Study Neurology 71:29-35 (PMID: 18509094).

Laramie JM, Wilk JB, Williamson S, Nagle MW, Latourelle JC, Tobin JE, Province MA, Borecki IB, Myers RH. 2008. Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; The NHLBI Family Heart Study. BMC Medical Genetics 9:46 (PMID: 18498660).

Wilk JB, Laramie JM, Latourelle JC, Williamson S, Nagle MW, Tobin JE, Leiendecker Foster C, Eckfeldt JH, Province MA, Borecki IB, Myers RH. 2008. NYD-SP18 is associated with obesity in the NHLBI Family Heart Study. International Journal of Obesity. 32:930-935 (PMID: 18317470).

Latourelle JC, Sun M, Lew MF, Suchowersky O, Klein C, Golbe LI, Mark MH, Growdon JH, Wooten GF, Watts RL, Guttman M, Racette BA, Perlmutter JS, Ahmed A, Shill HA, Singer C, Goldwurm S, Pezzoli G,Saint-Hilaire MH, Hendricks AE, Williamson S, Nagle MW, Wilk JB, Massood T, Huskey KW, Laramie JM, DeStefano AL, Baker K, Itin I, Litvan I, Nicholson G, Corbett A, Nance M, Drasby E, Isaacson S, Burn DJ, ChinneryPF, Pramstaller PP, Al-hinti J, Moller AT, Ostergaard K, Sherman SJ, RoxburghR, Snow B, Slevin JT, Cambi F, Gusella JF, Myers RH. 2008. The G2019S mutation in LRRK2 is not fully penetrant: The GenePD study BMC Medicine 6:23 (PMID: 18986508).

DeStefano AL, Latourelle JC, Lew MF, Suchowersky O, Klein C, Golbe LI, Mark MH, Growdon JH, Wooten GF, Watts RL, Guttman M, Racette BA, Perlmutter JS, Marlor L, Shill HA, Singer C, Goldwurm S, Pezzoli G, Saint-Hilaire MH, Hendricks AE, Gower A, Williamson S, Nagle MW, Wilk JB, Massood T, Huskey KW, Baker K, Itin I, Litvan I, Nicholson G, Corbett A, Nance M, Drasby E, Isaacson S, Burn DJ, Chinnery PF, Pramstaller PP, Al-hinti J, Moller AT, Ostergaard K, Sherman SJ, Roxburgh R, Snow B, Slevin JT, Cambi F, Gusella JF, Myers RH. 2008. Replication of Association between ELAVL4 and Parkinson Disease; The GenePD Study. Human Genetics 124:95-99 (PMID: 18587682).

Feitosa MF, Myers RH, Pankow JS, Province MA, Borecki IB. 2009. LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion. Atherosclerosis 204: 171-177 (PMID: 19101670).

Pankratz N, Wilk JB, Latourelle JC, DeStefano AL, Halter C, Pugh EW, Doheny KF, Gusella JF, Nichols WC, Foroud T, Myers RH, and the PSG –PROGENI and GenePD Investigators, Coordinators and Molecular Genetic Laboratories. 2009. Genomewide Association Study for Susceptibility Genes Contributing to Familial Parkinson Disease. Human Genetics. 124:593–605 (PMID: 18985386).

Wilk JB, Chen T-h, Gottlieb DJ, Walter RE, Nagle MW, Brandler BJ, Myers RH, Borecki IB, Silverman EK, Weiss ST, O’Connor GT. 2009. A Genome-wide Association Study of Pulmonary Function Measures in the Framingham Heart Study PLoS Genetics 5(3): (PMID: 19300500).

Technologies available for sharing upon request:

TaqMan Gene expression; SNP genotyping assays; Statistical genetic analytic methods for genome wide association studies; copy number variants; gene-gene interaction.