Edward J. Miller, M.D. Ph.D.

Assistant Professor of MedicineMiller_Edward-2.5x3 and Radiology

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Education:

Loyola University Stritch School of Medicine, Maywood, Il, 1999-M.D.
Yale University, New Haven, CT, 2008-Ph.D.

Links to other websites:

http://profiles.bu.edu/Edward.Miller

General Field of Work:

Metabolic heart disease, Cardiomyopathy, Nuclear Cardiology, Cardiac Sarcoidosis

Cardiac Amyloidosis

Affiliations other than medicine:

Boston University School of Medicine, Section of Cardiovascular Medicine, Myocardial Biology Unit

Contact information:

Office:
650 Albany Street, X704, Boston, MA 02481

Lab:
Myocardial Biology Laboratory Boston University Medical Center 650 Albany St., X704

Email:
ejmiller@bu.edu

Other websites linked to:

http://www.asnc.org/

Keywords:

Metabolic heart disease, cardiomyopathy, nuclear cardiology, cardiac sarcoidosis, mitochondrial metabolism

Summary of academic interest:

My research interest is in the regulation of energy metabolism in the heart, focusing on signaling pathways that are disrupted in diabetic/metabolic heart disease. The aims of my research are both to understand the basic mechanisms that are responsible for altered cardiomyocyte metabolism in obesity-related metabolic heart disease, but also to investigate therapeutic options that can improve cardiac function in metabolic heart disease. One major focus of my work is to understand mitochondrial function in metabolic heart disease and to develop new methods to measure mitochondrial function

My clinical interests are in the evaluation and treatment of patients with infiltrative cardiomyopathies, such as amyloidosis and sarcoidosis. In particular, my research in these areas focuses on use of nuclear imaging techniques such as FDG PET/CT to diagnose and monitor patients with cardiac sarcoidosis.

Recent Publications:

1.  Qin F, Siwik DA, Luptak I, Hou X, Wang L, Higuchi A, Weisbrod RM, Ouchi N, Tu VH, Calamaras TD, Miller EJ, Verbeuren TJ, Walsh K, Cohen RA, Colucci WS. The Polyphenols Resveratrol and S17834 prevent the Structural and Functional Sequelae of Diet-Induced Metabolic Heart Disease in Mice. Circulation. 2012 Apr 10; 125(14):1757-64

2.  Li J, Miller EJ, Young LH.  Urocortin 2 Autocrine/aracrine and Pharmacologic Effects to Activate AMP-Activated Protein Kinase in the Heart. PNAS. 2013 Oct 1;110(40):16133-8.

3.  Berman JS, Govender P, Ruberb FL, Mazzini M, Miller EJ.  Scadding Revisited:  A Proposed Staging System for Sarcoidosis Based on Advanced Imaging.  Sarcoidosis Vasc Diffuse Lung Dis. 2014.  In Press.

4.  Ahmadian A, Brogan A, Berman JS, Sverdlov AL, Mercier G, Mazzini M, Govender P, Ruberg RL, Miller EJ.  Quantitative Interpretation of FDG PET/CT with Myocardial Perfusion Imaging Increases the Diagnostic Information in the Evaluation of Cardiac Sarcoidosis.  J Nuc Card.  2014.  In Press.

5.  Perret P, Dahmani R, Just P, Delay A, Canal F, Finzi L, Prip-buus C, Lambert M, Sujobert P, Buchet-Poyau K, Miller EJ, Cavard C, Marmier S, Terris B, Billaud M.  A novel LKB1 isoform enhances AMPK metabolic activity and displays oncogenic properties.  Oncogene. 2014.  In Press

6. Baron S, Li J, Russell RR, Neumann D, Miller EJ, Tuerk R, Walliman T, Hurley R, Witters, LA, Young LH. Dual mechanisms regulating AMPK kinase action in the ischemic heart. Circulation Research, 2005. 96(3): p. 337-45. PMCID15653571

7. Miller EJ, Russell RR, Li J, Young LH. AMPK-a pivotal rheostat in the control of cardiac metabolism. Drug Discovery Today: Disease Mechanisms, 2005. 2(1): p. 93-100.

8. Li J, Miller EJ, Ninomiya-Tsuji J, Russell RR, Young LH. AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart. Circulation Research. 2005. 97(9):872-9. PMCID16179588

9. Li J, Coven DL, Miller EJ, Hu X, Young ME, Carling D, Sinusas AJ, Young LH. Activation of AMPK alpha- and gamma- Isoform Complexes in the Intact Ischemic Rat Heart. Am J Physiol Heart Circ Physiol. Oct;291(4):H1927-34. PMCID16648175

10. Miller EJ, Li J, Sinusas K, Holman GD, Young LH. Infusion of a biotinylated bis-glucose photolabel: A new method to quantify cell-surface GLUT4 in the intact mouse heart. Am J Physiol Endo. 2007. June;292(6):E1922-8. PMCID17341550

11. Miller EJ, Li J, Leng L, McDonald C, Atsumi, T, Bucala R, Young LH. Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischemic heart. Nature. 2008. Jan 31;451(7178): 578-82. PMCID18235500

12. Kim A, Miller EJ, Young LH. AMPK, a Core Signaling Pathway in the Heart. Acta Physiol (Oxf). 2009 May;196(1):37-53. PMCID19239414

Additional recent publications (in chronological order)

1. Ozcan C, Miller EJ, Russell KS, Dewar ML, Rosenfeld LE. An unusual case of nonbacterial thrombotic (marantic) endocarditis. J Thorac Cardiovasc Surg. 2009 Jan;137(1):239-41. PMCID19154931

2. Miller EJ, Russell RR. Physics and Instrumentation of Cardiac SPECT. Ho and Reddy: Imaging of the Cardiovascular System. Chapter 20. Eds. Ho V, Reddy G. Elsevier. 2010. p. XXX. In Press.

3. Amundson D, Dadekian G, Etienne M, Gleeson T, Hicks T, Killian D, Kratovil K, Lewis C, Monsour M, Pasiuk B, Rhodes D, Miller EJ. Practicing Internal Medicine Onboard the USNS COMFORT in the Aftermath of the Haitian Earthquake. Ann Intern Med. 2010 Mar 3. [Epub ahead of print] PMCID20197507