Mark E. McComb, PhD

Research Assistant Professor of Medicine

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Education:

PhD, University of Manitoba, Mass Spectrometry
Post doc, Boston University School of Medicine, Mass Spectrometry

General Field of Work:

Proteomics, Mass Spectrometry and Biomarker Discovery

Affiliations other than medicine:

Cardiovascular Proteomics Center
Center for Biomedical Mass Spectrometry
Evans Center for Interdisciplinary Biomedical Research
Vascular Biology Unit

Contact information:

Office and Lab: 670 Albany Street, suite 507
Phone: 617-638-4280
Fax: 617-638-4095
Email: mccomb@bu.edu

Other Links:

http://www.bumc.bu.edu/bucbm/faculty/mark-e-mccomb/
http://www.bumc.bu.edu/bucbm/
http://www.bumc.bu.edu/cardiovascularproteomics/
http://www.bumc.bu.edu/cardiovascularproteomics/proteomics-core-laboratory/
http://www.bumc.bu.edu/evanscenteribr/the-arcs/the-arcs/biomarkers-arc/
http://www.hupo.org/
http://www.ushupo.org/
http://www.asms.org/

Keywords:

Proteomics, Mass Spectrometry, Biomarkers, Cardiovascular Disease

Summary of academic interest:

Dr. McComb is a Research Assistant Professor of Medicine at Boston University School of Medicine (BUSM) and the Director of theDiscovery Proteomics Cardiovascular Proteomics Center (CPC) Core Research Laboratory part of the BUSM Center for Biomedical Mass Spectrometry. The CPC is one of 7 National Heart Lung and Blood Institute Proteomics Centers. Dr. McComb has authored/co-authored more than 40 peer-review publications, reviews and textbook chapters and has over 180 conference proceedings including many as invited speaker. Dr. McComb is an active member of the Human Proteome Organization (HUPO) whose mission is to characterize the entire human proteome. Dr. McComb’s research aims are directed towards the identification and characterization of differentially expressed proteins and differentially observed peptides and post-translational modifications (PTMs) associated with markers of huma! n disease with an emphasis directed towards cardiovascular disease. His laboratory focuses on applying mass spectrometry-based proteomics technology for the identification and characterization of proteins which may be perturbed by disease mechanism in-vivo. By studying these proteins and PTMs the aim is to identify patterns of changes and PTM events in order to gain a global comprehensive understanding of disease progression. Identification of specific proteins and PTMs which change as a function of disease will lead to the development of diagnostic and prognostic biomarkers which will have tremendous clinical utility.

Recent Publications:

Lavatelli, F., Perlman, D. H., Spencer, B., Prokaeva, T., McComb, M.E., Théberge, R., Connors, L. H., Bellotti, V., Seldin, D. C., Merlini, G., Skinner, M., and Costello, C. E., Amyloidogenic and associated proteins in systemic amyloidosis proteome of adipose tissue. Molecular & Cellular Proteomics, 2008. 7(8): p. 1570-1583.

Mathivanan, S., Ahmed, M., …, McComb, M.E., …, and Pandey, A., Human Proteinpedia enables sharing of human protein data. Nature Biotechnology, 2008. 26(2): p. 164-167.

Bhatia, V. N., Perlman, D. H., Costello, C. E., and McComb, M.E., Software Tool for Researching Annotations of Proteins: Open-Source Protein Annotation Software with Data Visualization. Analytical Chemistry, 2009. 81(23): p. 9819-9823.

Perlman, D. H., Bauer, S. M., Ashrafian, H., Bryan, N. S., Garcia-Saura, M. F., Lim, C. C., Fernandez, B. O., Infusini, G., McComb, M.E., Costello, C. E., and Feelisch, M., Mechanistic Insights Into Nitrite-Induced Cardioprotection Using an Integrated Metabolomic-Proteomic Approach. Circulation Research, 2009. 104(6): p. 796-U170.

Rex, S., Beaulieu, L. M., Perlman, D. H., Vitseva, O., Blair, P. S., McComb, M.E., Costello, C. E., and Freedman, J. E., Immune versus thrombotic stimulation of platelets differentially regulates signalling pathways, intracellular protein-protein interactions, and alpha-granule release. Thrombosis and Haemostasis, 2009. 102(1): p. 97-110.

Romesser, P. B., Perlman, D. H., Faller, D. V., Costello, C. E., McComb, M.E., and Denis, G. V., Development of a Malignancy-Associated Proteomic Signature for Diffuse Large B-Cell Lymphoma. American Journal of Pathology, 2009. 175(1): p. 25-35.

Ying, W. T., Perlman, D. H., Li, L., Théberge, R., Costello, C. E., and McComb, M.E., Highly efficient and selective enrichment of peptide subsets combining fluorous chemistry with reversed-phase chromatography. Rapid Communications in Mass Spectrometry, 2009. 23(24): p. 4019-4030.

Zee, R.S., Yoo, C.B., Pimentel, D.R., Perlman, D.H., Burgoyne, J.R., Hou, X., McComb, M.E., Costello, C.E., Cohen, R.A., Bachschmid, M.M., Redox regulation of sirtuin-1 is mediated by Sglutathiolation, Antioxidants & Redox Signaling, 2010. 13(7): p. 1023-1032.

Théberge, R. Infusini, G., Tong, W., McComb, M.E., Costello, C.E., Top-down analysis of small plasma proteins using an LTQ-Orbitrap: Potential for mass spectrometry-based clinical assays for transthyretin and haemoglobin, Int. J. Mass Spectrom., 2011. 300(2-3): p. 130-142.