Hector Lucero

Research Assistant Professor

Education:

Ph.D in Biochemistry, University of Buenos Aires Argentina

Post Doctoral Training, Department of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY

General field of research:

Extracellular Enzyme Activities- Biochemistry,  Cell and Molecular Biology – Protein Trafficking

Affiliations other than medicine:

Evans Center for Interdisciplinary Biomedical Research
Hypertension and Atherosclerosis Section, Department of Medicine

Contact information:

Office
W 508
Phone: (617)-638 4075

Lab
W 524
Phone:  (617)-638 4075

hlucero@bu.edu

Keywords:

Protein trafficking; Gene expression; Cell Signaling

Summary of research interest:

Elucidation of novel molecular mechanisms involved in the retro-translocation of exogenous Angiotensin Converting Enzyme (ACE) leading to the nuclear localization of the enzyme and subsequent modulation of gene expression.

Recent publications:

Amparo Romero, Isin Cakir, Charles A. Vaslet, Ronald C. Stuart, Omar Lansari, Hector A. Lucero, and Eduardo A. Nillni.  (2008) Role of a pro-sequence in the secretory pathway of pro thyrotropin releasing hormone (proTRH) J. Biol. Chem, 283, 31438-31448.

Héctor A. Lucero, Katya Ravid, Jessica L. Grimsby, Sandra J. DiCamillo, Joni M. Mäki , Johanna Myllyharju and Herbert M. Kagan. (2008) Lysyl Oxidase Oxidizes Cell Membrane Proteins and Enhances the Chemotactic Response of Vascular Smooth Muscle Cells. J. Biol. Chem.  283, 24103 – 24117.

Héctor A. Lucero and Herbert M. Kagan. (2006) Lysyl oxidase: an oxidative enzyme and effector of cell function. Cell Mol Life Sci. 63, 2304-2316.

Héctor A. Lucero and Phillips W. Robbins. (2004) Lipid raftsprotein association and the regulation of protein activity Arch. Biochem. Biophys. 426, 208224.

Héctor A. Lucero, Daren Gae, Guillermo E. Taccioli. (2003) Novel localization of the DNA-PK complex in lipid rafts: a putative role in the signal transduction pathway of the ionizing radiation response. J Biol Chem. 278, 22136-43.

Dorota A. Bulik, Mariusz Olczak, Héctor A. Lucero, Barbara C. Osmond, Phillips W. Robbins, and Charles A. Specht. (2003) Chitin synthesis in Saccharomyces cerevisiae in response to supplementation of growth medium with glucosamine and cell wall stress Eukaryotic Cell 2, 886900.

Héctor A. Lucero, Michael J. Kuranda and Dorota Bulik. (2002) A Non-radioactive, High Throughput Assay for Chitin Synthase Activity. Anal. Biochem. 305, 97-105.

Héctor A. Lucero, and Benjamin Kaminer. (1999) “The role of calcium on the activity of ERcalcistorin/protein disulfide isomerase and the significance of the C-terminal and its calcium binding: a comparison with mammalian protein disulfide. J. Biol. Chem. 274, 3243-3251.

Technologies available for sharing upon request:

Chemotaxis, Cell Migration and Cell Invasion Assay

Signal Transducing Pathway Assay

Membrane Protein and Soluble Protein Purification

Binding of 125I-labeled Ligands to Cell Monolayers

Fluorescent Wide Field and Confocal Microscopy

Cell Trafficking and Subcellular Localization

Enzymatic Assay and Analysis

Protein Phosphorylation and Processing