Elizabeth S. Klings, MD

Assistant Professor

Education:

MD – New York University School of Medicine

General field of research:

Pulmonary Hypertension and Sickle Cell Disease

Affiliations other than medicine:

Evans Center for Interdisciplinary Biomedical Research
Department of Medicine
Pulmonary Center
Comprehensive Sickle Cell Center

Contact information:

Office
C639

Lab
R-304

klingon@bu.edu

Other research websites:

http://www.bumc.bu.edu/pulmonary/people/elizabethklings/

Summary of research interest:

Dr. Klings’ research focuses on the role of altered nitric oxide biology and oxidative stress in the pathogenesis of pulmonary vascular complications of sickle cell disease. She is an NIH-funded Principal Investigator and a member of the Vascular Biology Research Group of the Pulmonary Center . Additionally, Dr. Klings is an investigator in the Boston Comprehensive Sickle Cell Center, the Genetic Modulation of Sickle Cell Disease Research group and the Cardiovascular Proteomics Center at Boston University . Through collaborative efforts with each of these groups, Dr. Klings has screened over 150 sickle cell disease patients at Boston Medical Center for pulmonary hypertension. This cohort of patients is being studied for genetic modifiers associated with the development of pulmonary hypertension. Additionally, the role of oxidative post-translational protein modification in disease pathogenesis is being explored

Recent publications:

Klings, E.S., D.A. Bland, D. Rosenman, S. Princeton, A. Odhiambo, G. Li, S.A. Bernard, M.H. Steinberg, H.W. Farber. 2008. Pulmonary Arterial Hypertension and Left-Sided Heart Disease in Sickle Cell Disease: Clinical Characteristics and Association with Soluble Adhesion Molecule Expression. Am J Hematol 83(7): 547-553.

Morris, C.R., J.H. Suh, S. Larkin, D.A. Bland, M.H. Steinberg, E.P. Vichinsky, M. Shigenaga, B. Ames, F.A. Kuypers, E.S. Klings. 2008. Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease. Blood 111(1): 402-10.

Klings, E.S. 2008. Pulmonary Hypertension of Sickle Cell Disease: More Than Just Another Lung Disease (Editorial). Am J Hematol 83(1): 4-5.

Odhiambo, A., D.H. Perlman, H. Huang, C.E. Costello, H.W. Farber, M.H. Steinberg, M.E. McComb, E.S. Klings. 2007. Identification of oxidative post-translational modification of serum albumin in patients with idiopathic pulmonary arterial hypertension and pulmonary hypertension of sickle cell anemia. Commun Mass Spectrom 21: 2195-2203.

Klings, E.S., D.F. Wyszynski, V.G. Nolan, M.H. Steinberg. 2006. Abnormal Pulmonary Function in Adults with Sickle Cell Anemia: Association of Decreased D L CO with Systemic Disease. Amer J Resp Crit Care Med 173: 1264-1269.

Klings, E.S., S. Safaya, A.H. Adewoye, A. Odhiambo, G. Frampton, M Lenburg, N. Gerry, P. Sebastiani, M.H. Steinberg, H.W. Farber. 2005. Differential Gene Expression in Pulmonary Artery Endothelial Cells Exposed to Sickle Cell Plasma. Physiol Genomics 21: 293-8.

Klings E.S., B.W. Christman, J. McClung, A.F. Stucchi, L. McMahon, M. Brauer, H.W. Farber. 2001. Increased oxidative stress in the acute chest syndrome of sickle cell disease: Demonstration in vivo using F2 isoprostanes. Amer J Resp and Crit Care Med 164: 1248-1252.

Klings E.S., H.W. Farber. 2001. The role of free radicals in the pathogenesis of acute chest syndrome of sickle cell disease (review). Resp Research 2:280-285.