General field of research:
Lung Cancer; Mechanisms of Lung Cancer Progression
Affiliations other than medicine:
Evans Center for Interdisciplinary Biomedical Research
Pulmonary/ Critical Care
715 Albany Street R304
Phone: (617) 638 4860
Phone: (617) 638 4868
Fax: (617) 536 8093
Other research websites:
Research group information
mechanisms of lung cancer metastases
Summary of research interest:
Dr. Kathuria’s research focuses on developing a gene-expression signature, applied to histologically tumor-free lymph nodes obtained at surgical resection for curative intent in early stage NSCLC, that can guide subsequent treatment decisions to optimize patient outcomes. In addition she is interested in understanding the molecular mechanisms regulating caveolin-1 and other target genes by ETS transcription factors in lung tumor progression.
Sloan KA, Marquez HA, Li J, Cao YX, Hinds A O’Hara CJ, Kathuria S, Ramirez MI, Williams MC, and Kathuria H. 2009. Increased PEA3/E1AF and Decreased Net/Elk-3, both Ets Proteins, Characterize Human NSCLC Progression and Regulate Caveolin-1 Transcription in Calu-1 and NCI-H23 NSCLC Cell Lines. in press, Carcinogenesis.
Kathuria H, Spira A, Brody J. 2007 “Genomics of Lung Cancer” in Handbook of Genomic Medicine. Elsevier Press, in press.
Kathuria H, Cao Y, Hinds A, Ramirez MI, Williams MC. 2007. ERM is expressed by alveolar epithelial cells in adult mouse lung and regulates caveolin-1 transcription in mouse lung epithelial cell lines. J Cell Biochem. 102(1): 13-27.
Sloan, K.A., Hinds, A., Akkanti, B., Williams, M.C., and Kathuria, H. 2006 Changes in Caveolin-1 Expression as a Function of Human Lung Adenocarcinoma Progression (A) Proc Amer Thor Soc.
Kathuria H, Cao YX, Williams MC, Ramirez MI. 2005. ETS proteins regulate caveolin-1 transcription. Proc Amer Thor Soc. 2: 735(A).
Kathuria H, Cao YX, Ramirez MI, Williams, MC. 2004. Transcription of the caveolin-1 gene is differentially regulated in lung type I epithelial and endothelial cell lines: A role for ETS proteins in epithelial cell expression. J. Biol. Chem. 279: 30028-30036.
Technologies available for sharing upon request:
RNA isolation from paraffin-embedded tissue