Elaine Hylek, MD, MPH

HylekProfessor of Medicine

Medical School:

University of Pittsburgh


Massachusetts General Hospital

Affiliations other than medicine:

Section of General Internal Medicine

Contact information:

801 Massachusetts Ave, Crosstown 2, Boston, MA 02118

Phone: (617) 414-3743

Fax: (617) 414-4676


cardiovascular disease; atrial fibrillation; thrombatic diseases; anticoagulation; hypertension; stroke prevention

Summary of research interest:

Dr. Elaine Hylek’s clinical research interests include cardiovascular disease, atrial fibrillation, thrombatic diseases, anticoagulation, diabetes, hypertension, stroke prevention, and quality improvement. Dr. Hylek maintains a patient panel in the primary care clinic at Yawkey ACC.

Recent publications:

Hlatky MA, Douglas PS, Cook NL, Wells B, Benjamin EJ, Dickersin K, Goff DC, Hirsch AT, Hylek EM, Peterson ED, Roger VL, Selby JV, Udelson JE, Lauer MS. Future directions for cardiovascular disease comparative effectiveness research: Report of a workshop sponsored by the National Heart, Lung, and Blood Institute. J Am Coll Cardiol. 2012. PMID: 22796257.

Easton JD, Lopes RD, Bahit MC, Wojdyla DM, Granger CB, Wallentin L, Alings M, Goto S, Lewis BS, Rosenqvist M, Hanna M, Mohan P, Alexander JH, Diener HC; ARISTOTLE Committees and Investigators. Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: A subgroup analysis of the ARISTOTLE trial. Lancet Neurol. 2012 Jun;11(6):503-11. PMID: 22572202.

You JJ, Singer DE, Howard PA, Lane DA, Eckman MH, Fang MC, Hylek EM, Schulman S, Go AS, Hughes M, Spencer FA, Manning WJ, Halperin JL, Lip GY. Antithrombotic therapy for atrial fibrillation: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012 Feb;141(2 Suppl):e531S-75S. PMID: 22315271.

Rose AJ, Petrakis BA, Callahan P, Mambourg S, Patel D, Hylek EM, Bokhour BG. Organizational characteristics of high- and low-performing anticoagulation clinics in the Veterans Health Administration. 2012 Aug;47(4):1541-60. PMID: 22299722. doi: 10.1111/j.1475-6773.2011.01377.x.

Rose AJ, Berlowitz DR, Miller DR, Hylek EM, Ozonoff A, Zhao S, Reisman JI, Ash AS. INR targets and site-level anticoagulation control: Results from the Veterans AffaiRs Study to Improve Anticoagulation (VARIA). J Thromb Haemost. 2012 Apr;10(4):590-5. doi: 10.1111/j.1538-7836.2012.04649.x. PMID: 22288563.

Ageno W, Gallus AS, Wittkowsky A, Crowther M, Hylek EM, Palareti G. Oral anticoagulant therapy: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012 Feb;141(2 Suppl):e44S-88S. PMID: 22315269.

Hanchate AD, Schwamm LH, Huang W, Hylek EM. Comparison of ischemic stroke outcomes and patient and hospital characteristics by race/ethnicity and socioeconomic status. Stroke. 2013 Feb;44(2):469-76. PMID: 23306327.

Jasuja GK, Reisman JI, Miller DR, Berlowitz DR, Hylek EM, Ash AS, Ozonoff A, Zhao S, Rose AJ. Identifying major hemorrhage with automated data: Results of the Veterans Affairs Study to improve anticoagulation (VARIA). Thromb Res. 2013 Jan;131(1):31-6. PMID:23158402.

Lopes RD, Al-Khatib SM, Wallentin L, Yang H, Ansell J, Bahit MC, De Caterina R, Dorian P, Easton JD, Erol C, Ezekowitz JA, Gersh BJ, Granger CB, Hohnloser SH, Horowitz J, Hylek EM, McMurray JJ, Mohan P, Vinereanu D, Alexander JH. Efficacy and safety of apixaban compared with warfarin according to patient risk of stroke and of bleeding in atrial fibrillation: a secondary analysis of a randomised controlled trial. Lancet. 2012 Nov 17;380(9855):1749-58.PMID: 23036896.

Lopes RD, Becker RC, Newby LK, Peterson ED, Hylek EM, Granger CB, Crowther M, Wang T, Carvalho AC, Berwanger O, Giraldez RR, Feitosa GS, Ribeiro JP, Darze E, Kalil RA, Andrande M, Boas FV, Andrade J, Rocha AT, Harrington RA, Lopes AC, Garcia DA. Highlights from the IV International Symposium of Thrombosis and Anticoagulation (ISTA), October 20-21, 2011, Salvador, Bahia, Brazil. J Thromb Thrombolysis. 2012 Jul;34(1):143-63. PMID: 22427055.

Witt DM, Delate T, Garcia DA, Clark NP, Hylek EM, Ageno W, Dentali F, Crowther MA. Risk of thromboembolism, recurrent hemorrhage, and death after warfarin therapy interruption for gastrointestinal tract bleeding. Arch Intern Med. 2012 Oct 22;172(19):1484-91. PMID: 22987143.

PubMed link to Dr. Hylek’s publications