Andrew J. Henderson

Associate Professor

Education:

Ph.D., University of California, Riverside
Post-Doc, Columbia University

General field of research:

HIV Transcription and Signal Transduction

Affiliations other than medicine:

Evans Center for Interdisciplinary Biomedical Research
Department of Medicine and Microbiology Section of Infectious Diseases
Center for HIV/AIDS Care and Research

Contact information:

Office
645 EBRC
Phone: (617) 414-5240

Lab
640 EBRC

andrew.henderson@bmc.org

Other research websites:

www.bumc.bu.edu/Dept/Content.aspx?DepartmentID=59&PageID=12921
www.bmc.org/hiv%2Daids/Research_Faculty_Henderson.htm

Research group information

Gillian Schiralli Lester, Post-Doc gms13@psu.edu
Chanhyo Lee, Post-Doc chanhyo.lee@bmc.org
Malini Natarajan, Grad Student malini@bu.edu
Daniele Cary, Grad student daniele.cary@bmc.org

Keywords:

HIV Latency Transcription Signal Transduction T cells Macrophages

Summary of research interest:

My research focuses on cellular mechanisms that regulate HIV replication and transcription. Active projects in the lab include elucidating T cell costimulatory signal transduction cascades that positively and negatively regulate HIV transcription, determining mechanisms by which HIV circumvents anti-inflammatory signals to promote HIV replication and AIDS-associated inflammatory diseases and characterizing the transcriptional status of HIV provirus in T cell and macrophage subsets. Although, HIV is our primary experimental system, our research provides general insights into signal transduction, tissue-specific gene expression, immune cell function and mechanisms that contribute to inflammatory disorders and autoimmunity.

Recent publications:

Zhang, Z., A. Klatt, D.S. Gilmour, A.J. Henderson. 2007. Negative Elongation Factor, NELF, Represses HIV Transcription by Pausing RNA Polymerase II Complex. J. Biol. Chem. 282:16981-16988. (PMID: 17442680)

Zhang, Z., A. Klatt. A.J. Henderson, D.S. Gilmour. 2007. Transcription termination factor Pcf11 limits the processivity of Pol II on an HIV provirus to repress gene expression. Genes Dev. 21: 1609-1614. (PMC1899470)

Klatt A., Z. Zhang, P. Kalantari, P. Hankey, D.S. Gilmour, A.J. Henderson. 2008. The Receptor Tyrosine Kinase RON represses HIV-1 Transcription by Targeting RNA Polymerase II Processivity. J. Immunol. 180:1670-1677. (PMID: 18209063)

Readinger, J.A., G.M. Schiralli, J-K. Jiang, C.Thomas, A. August, A.J. Henderson, P.L. Schwartzberg. 2008. Selective targeting of ITK blocks multiple steps of HIV replication. Proc. Natl. Acad. Sci. USA. 105:6684-6689. (PMC2365562)

Kalantari, P., O. Harandi, P. Hankey, A.J. Henderson. 2008. HIV-1 Tat mediates degradation of RON receptor tyrosine kinase, a regulator of inflammation. J.Immunol. 181:1548-1555. (PMC2536764)

Strasner, A.B., M. Natarajan, T. Doman, D. Key, A. August, A.J. Henderson. 2008. The Src kinase Lck facilitates assembly of HIV-1 at the plasma membrane. J. Immunol. 181:3706-3713. (PMC2587142)