Haralambos Gavras MD

Gavras_HProfessor of Medicine

Education:

M.D. – Athens University School of Medicine

General field of research:

Hypertension, Cardiovascular diseases

Affiliations other than medicine:

Evans Center for Interdisciplinary Biomedical Research
Chief, Section of Hypertension and Atherosclerosis, Boston Medical Center.
Cardiovascular Institute, B.U.S.M.

Contact information:

Office
700 Albany Street, W-508
Phone: (617) 638-4025

Lab
700 Albany Street, W-508
Fax: (617) 638-4027

hgavras@bu.edu

Other research websites:

http://www.bumc.bu.edu/medicine/hypertension/

Research group information

Irene Gavras MD Clinical Investigator igavras@bu.edu
Hector Lucero PhD Cellular Biologist hlucero@bu.edu
Ekaterina Kintsurashvili PhD Molecular Biologist ekint@bu.edu
Maria Marketou MD Research Fellow marketou@bu.edu
Theodora Anagnostou MD Research Fellow

Keywords:

Renin-angiotensin; Angiotensin-converting enzyme; Bradykinin adrenergic receptors

Summary of research interest:

Studies in the pathophysiology and mechanisms of hypertension. Experimental models of renin-dependent, salt-dependent and hyperadrenergic mechanisms of hypertension. Non-enzymatic properties of the angiotensin-converting enzyme. Molecular mechanisms of angiotensin-induced cardiomyopathy.

Vasoregulatory and metabolic role of the B1 and B2 receptors of bradykinin.

Recent publications:

Ignjacev-Lazich I, Kintsurashvili E, Johns C, Vitseva O, Duka A, Shenouda S, Gavras I, Gavras H. 2005.Angiotensin-converting enzyme regulates bradykinin receptor gene expression. Am J Physiol Heart Circ Physiol 289: H1814-H1820. PMID: 16219810

Duka A, Schwartz F, Duka I, Johns C, Melista E, Gavras I, Gavras H. 2006. A novel Gene (Cmya3) induced in the heart by angiotensin II dependent but not salt dependent hypertension in mice. Am J Hypertens 19: 275-281. PMID: 16500513

Yang D, Zhang Y, Nguyen HG, Koupenova M, Chauhan AK, Makitalo M, Jones MR, St Hilaire C, Seldin DC, Toselli P, Lamperti E, Schreiber BM, Gavras H, Wagner DD, Ravid K. 2006. The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. J Clin Invest 116:1913-1923. PMID: 16823489

Shenouda SM, Johns C, Gavras I, Gavras H. 2006. Long-Term Inhibition of the Central alpha(2B)-Adrenergic Receptor Gene Via Recombinant AAV-Delivered Antisense in Hypertensive Rats. Am J Hypertens 19:1135-1143. PMID: 17070424

Sun B, Kintsurashvili E, Ona D, Ignjacev-Lazich I, Gavras I, Gavras H. 2007. Inhibition of the alpha(1D)-adrenergic receptor gene by RNA interference (RNAi) in rat vascular smooth muscle cells and its effects on other adrenergic receptors. Vascul Pharmacol 46:367-372. PMID: 17307398

Duka A, Kintsurashvili E, Duka I, Ona D, Hopkins TA, Bader M, Gavras I, Gavras H. 2008. Angiotensin-converting enzyme inhibition after experimental myocardial infarct: role of the kinin B1 and B2 receptors. Hypertension 51:1352-1357. PMID: 18347228

Kintsurashvili E, Shenouda S, Ona D, Ona L, Ahmad S, Ravid K, Gavras I, Gavras H. 2009. Hypertension in transgenic mice with brain-selective overexpression of the alpha2B-adrenoceptor. Am J Hypertens 22:41-45. PMID: 18989257

Gavras, H. 2009. Pathogenesis of Hypertension: A Review. J Med Sci 2:25-28.

Lucero HA, Kintsurashvili E, Marketou ME, Gavras H: Cell signaling, internalization and nuclear localization of the angiotensin converting enzyme in smooth muscle cells and endothelial cells. J Biol Chem 285:5555-5568, 2010. PMID:20022959

McCalmon SA, Desjardins DM, Ahmad S, Davidoff KS, Snyder CM, Sato K, Ohashi K, Kielbasa OM, Mathew M, Ewen EP, Walsh K, Gavras H, Naya FJ: Modulation of Angiotensin II-Mediated Cardiac Remodeling by the MEF2A Target Gene Xirp2. Circ Res 106: 952-960, 2010.PMID: 20093629

Marketou M, Kintsurashvili E,  Papanicolaou KN, Lucero HA, Gavras I,  Gavras H Cardioprotective effects of a selective b2 receptor agonist of bradykinin post acute myocardial infarct.  Am J Hypertens 23:562-568, 2010. PMID: 20186129

Manolis AJ, Marketou ME, Gavras I, Gavras H: Cardioprotective properties of bradykinin: role of the B(2) receptor. Hypertens Res 33:772-777, 2010. PMID: 20093629

Technologies available for sharing upon request:

Blood pressure measurements; cardiac hemodynamics in rats and mice.
Animal protocols: AN-13857 – “Cardioprotective properties of bradykinin” and AN-14460 – “Ischemic cardiomyopathy by coronary ligation in rats and mice”.