Jane E. Freedman, MD

Professor

Education:

BA, Yale University
MD, Tufts University

General field of research:

Thrombosis, Inflammation, Gene Expression

Affiliations other than medicine:

Evans Center for Interdisciplinary Biomedical Research
Pharmacology and Experimental Therapeutics
Whitaker Cardiovascular Institute

Contact information:

Office
700 Albany Street, W507

Lab
Phone: 617-638-4106
Fax: 617-638-4066

freedmaj@bu.edu

Research group information

Lea Beaulieu, lmb@bu.edu

Kahraman Tanriverdi, kahraman@bu.edu

Kristine Morin, kmmorin@bu.edu

Olga Vitseva, vitseva@bu.edu

Subrata Chakrabarti, subrata@bu.edu

Muhammad Rizvi,  ariz77@hotmail.com

Keywords:

Platelets, Thrombosis, Inflammation, Immunity, Gene Expression, High Throughput

Summary of research interest:

The major research initiatives in the laboratory emphasize the regulation of pathways contributing to atherothrombotic disease and how these factors contribute to acute coronary syndromes.  In addition, a second laboratory contains high-throughput equipment for biomarker, DNA, and RNA analyses and uses these facilities in collaboration with clinical and basic studies.

Specific ongoing projects include:

  • The role of platelet-dependent thrombosis in unstable cardiovascular syndromes.
  • The role of innate immunity and infection in platelet-dependent thrombosis (M. Rizvi).
  • The role of innate immunity and infection in megakaryocytic function (L. Beaulieu).
  • Platelet imaging (O. Vitseva).
  • The role of obesity in thrombosis and gene expression.
  • Gene Expression in cardiovascular disease in the Framingham Heart Study.
  • The role of miRNA in the regulation of platelet function (K. Tanriverdi, K. Morin).
  • The role of the CD40-CD40L interaction in vascular cellular interaction (S. Chakrabarti).

Recent publications:

Freedman JE.  Molecular Regulation of Platelet-dependent Thrombosis.  Circulation.  2005; 12(17):2725-34.

Chakrabarti S, Varghese S, Vitseva O, Tanriverdi K, Freedman JE.  CD40 Ligand Influences Platelet Release of Reactive Oxygen Intermediates.  Arteriosclerosis, Thrombosis, and Vascular Biology.  2005;25:2428-2434.

Chakrabarti S, Blair P, Freedman JE.  CD40-40L Signaling in Vascular Inflammation.  Journal of Biological Chemistry.  2007;282(25):18307-17.

Freedman JE.  Translational Therapeutics at the Platelet Vascular Interface: Oxidative Stress and Platelets.  Arteriosclerosis, Thrombosis, and Vascular Biology.  2008 28(3):s11-6.

Blair PS, Rex S, Vitseva O, Beaulieu L, Tanriverdi K, Chakrabarti S, Hayashi C, Genco CA, Iafrati M, Freedman, JE.  Stimulation of Toll-like Receptor 2 in Human Platelets Induces a Thrombo-Inflammatory Response Through Activation of Phosphoinositide 3-Kinase.  Circulation Research. 2008 104(3):346-54.

Freedman JE, Hylek E.  Clopidogrel, genetics, and drug responsiveness.  New England Jnl of Medicine.  2009 Jan 22;360(4):411-3.

Rex S, Beaulieu LM, Perlman DH, Vitseva O, Blair PS, McComb ME, Costello CE, Freedman JE.  Immune vs. thrombotic stimulation of platelets differentially regulates signaling pathways, intracellular protein-protein interactions, and alpha-granule release. Thrombosis and Haemostasis.  In press 2009.

Technologies available for sharing upon request:

High Throughput Gene Expression and Clinical Translational Research Core Facility