Emergency BU Alert BU Medical Campus OPEN Jan. 28, 2015 Boston University Medical Campus will be open Wednesday, Jan. 28, 2015. BUSM classes will be held as scheduled. Staff should check with their managers regarding work schedules. Medical, PA and GMS students who are assigned to inpatient services or clinics are expected to be present, if possible. Students who are assigned to outpatient services should check with their course director or the policy at the clinical site. GMS classes are canceled. Staff should check with their manager regarding their work schedules. The Henry M. Goldman School of Dental Medicine will follow normal school hours. All Patient Treatment Centers will be open for patient care and all classes will be held as scheduled. BU School of Public Health classes are canceled; SPH non-essential staff may telecommute. Employees who are part of the BUMC parking program should park in your assigned lot or garage. The Boston parking ban is still in effect. For updated information, please call the weather/emergency hotline at 617-638-6886 or visit the BU Emergency Communications website at http://www.bu.edu/ehs/comm/

Jane E. Freedman, MD

Professor

Education:

BA, Yale University
MD, Tufts University

General field of research:

Thrombosis, Inflammation, Gene Expression

Affiliations other than medicine:

Evans Center for Interdisciplinary Biomedical Research
Pharmacology and Experimental Therapeutics
Whitaker Cardiovascular Institute

Contact information:

Office
700 Albany Street, W507

Lab
Phone: 617-638-4106
Fax: 617-638-4066

freedmaj@bu.edu

Research group information

Lea Beaulieu, lmb@bu.edu

Kahraman Tanriverdi, kahraman@bu.edu

Kristine Morin, kmmorin@bu.edu

Olga Vitseva, vitseva@bu.edu

Subrata Chakrabarti, subrata@bu.edu

Muhammad Rizvi,  ariz77@hotmail.com

Keywords:

Platelets, Thrombosis, Inflammation, Immunity, Gene Expression, High Throughput

Summary of research interest:

The major research initiatives in the laboratory emphasize the regulation of pathways contributing to atherothrombotic disease and how these factors contribute to acute coronary syndromes.  In addition, a second laboratory contains high-throughput equipment for biomarker, DNA, and RNA analyses and uses these facilities in collaboration with clinical and basic studies.

Specific ongoing projects include:

  • The role of platelet-dependent thrombosis in unstable cardiovascular syndromes.
  • The role of innate immunity and infection in platelet-dependent thrombosis (M. Rizvi).
  • The role of innate immunity and infection in megakaryocytic function (L. Beaulieu).
  • Platelet imaging (O. Vitseva).
  • The role of obesity in thrombosis and gene expression.
  • Gene Expression in cardiovascular disease in the Framingham Heart Study.
  • The role of miRNA in the regulation of platelet function (K. Tanriverdi, K. Morin).
  • The role of the CD40-CD40L interaction in vascular cellular interaction (S. Chakrabarti).

Recent publications:

Freedman JE.  Molecular Regulation of Platelet-dependent Thrombosis.  Circulation.  2005; 12(17):2725-34.

Chakrabarti S, Varghese S, Vitseva O, Tanriverdi K, Freedman JE.  CD40 Ligand Influences Platelet Release of Reactive Oxygen Intermediates.  Arteriosclerosis, Thrombosis, and Vascular Biology.  2005;25:2428-2434.

Chakrabarti S, Blair P, Freedman JE.  CD40-40L Signaling in Vascular Inflammation.  Journal of Biological Chemistry.  2007;282(25):18307-17.

Freedman JE.  Translational Therapeutics at the Platelet Vascular Interface: Oxidative Stress and Platelets.  Arteriosclerosis, Thrombosis, and Vascular Biology.  2008 28(3):s11-6.

Blair PS, Rex S, Vitseva O, Beaulieu L, Tanriverdi K, Chakrabarti S, Hayashi C, Genco CA, Iafrati M, Freedman, JE.  Stimulation of Toll-like Receptor 2 in Human Platelets Induces a Thrombo-Inflammatory Response Through Activation of Phosphoinositide 3-Kinase.  Circulation Research. 2008 104(3):346-54.

Freedman JE, Hylek E.  Clopidogrel, genetics, and drug responsiveness.  New England Jnl of Medicine.  2009 Jan 22;360(4):411-3.

Rex S, Beaulieu LM, Perlman DH, Vitseva O, Blair PS, McComb ME, Costello CE, Freedman JE.  Immune vs. thrombotic stimulation of platelets differentially regulates signaling pathways, intracellular protein-protein interactions, and alpha-granule release. Thrombosis and Haemostasis.  In press 2009.

Technologies available for sharing upon request:

High Throughput Gene Expression and Clinical Translational Research Core Facility