Irene Gavras MD


Professor of Medicine


M.D. – Athens University School of Medicine

General field of research:

Hypertension, Cardiovascular diseases

Affiliations other than medicine:

Section of Hypertension and Atherosclerosis, Department of Medicine
Cardiovascular Institute

Contact information:

700 Albany street, W-508
Phone: (617) 638-4026
Fax: (617) 638-4027


Pathophysiology and Treatments of Hypertension; Experimental; Clinical

Summary of research interest:

Role of various components of the renin-angiotensin system in hypertension and ischaemic heart disease.

Cardioprotective effects of angiotensin converting enzyme inhibition. Cardiovascular and metabolic properties of bradykinin analogues.

Recent publications:

Rosenthal T, Gavras I. 2006. Fixed-drug combinations as first-line treatment for hypertension. Prog Cardiovasc Dis 48:416-425. PMID: 16714161

Cardoso de Carvalho F, Bregagnollo E, Santos Silva V, Brunie A, da Silva Franco RJ, Martin LC, Gavras I, Gavras H. 2006. Frequency of coronary artery disease in patients with renal artery stenosis without clinical manifestations of coronary insufficiency. Am J Hypertens 19:1125-1128. PMID:17070422.

Sun B, Kintsurashvili E, Ona D, Ignjacev-Lazich I, Gavras I, Gavras H. 2007. Inhibition of the alpha(1D)-adrenergic receptor gene by RNA interference (RNAi) in rat vascular smooth muscle cells and its effects on other adrenergic receptors. Vascul Pharmacol 46:367-372. PMID: 17307398

Duka A, Kintsurashvili E, Duka I, Ona D, Hopkins TA, Bader M, Gavras I, Gavras H. 2008. Angiotensin-converting enzyme inhibition after experimental myocardial infarct: role of the kinin B1 and B2 receptors. Hypertension 51:1352-1357. PMID: 18347228

Gavras H, Gavras I. 2008. Vasopressin Inhibitors. In: Hypertension Primer, Fourth Edition. Editors: Joseph L. Izzo, Jr.,Domenic A. Sica and Henry R. Black. Published by Lippincott Williams & Wilkins, Philadephia, PA, pp 474-476.

Silva VS, Martin LC, Franco RJ, Carvalho FC, Bregagnollo EA, Castro JH, Gavras I, Gavras H. 2008. Pleiotropic Effects of Statins May Improve Outcomes in Atherosclerotic Renovascular Disease. Am J Hypertens 21:1163-1168.

Kintsurashvili E, Shenouda S, Ona D, Ona L, Ahmad S, Ravid K, Gavras I, Gavras H. 2009. Hypertension in transgenic mice with brain-selective overexpression of the alpha2B-adrenoceptor. Am J Hypertens 22:41-45. PMID: 18989257

Rosenthal T, Gavras I. 2009. Angiotensin inhibition and malignancies: a review. J Hum Hypertens. PMID: 19339998

Marketou M, Kintsurashvili E,  Papanicolaou KN, Lucero HA, Gavras I,  Gavras H Cardioprotective effects of a selective b2 receptor agonist of bradykinin post acute myocardial infarct.  Am J Hypertens 23:562-568, 2010. PMID: 20186129

Manolis AJ, Marketou ME, Gavras I, Gavras H: Cardioprotective properties of bradykinin: role of the B(2) receptor. Hypertens Res 33:772-777, 2010. PMID: 20093629