Katya Ravid

Professor of Medicine and Biochemistry

Founding Director, Evans Center for Interdisciplinary Biomedical Research

Director, BU Interdisciplinary Biomedical Research Office


DSc/PhD, Technion-Israel Institute of Technology

Post-Doc, Massachusetts Institute of Technology

General field of research:

Blood Stem Cells and Hematological Malignancies; Cardiovascular Disease

Affiliations other than medicine:

Evans Center for Interdisciplinary Biomedical Research (Medical Campus)

BU Interdisciplinary Biomedical Research Office (Charles River Campus)

Whitaker Cardiovascular Institute

Pharmacology and Experimental Therapeutics

Department of Biochemistry

BU Sargent College

Contact information:


700 Albany Street, W-601

Boston, MA 02118

Phone: (617) 638-5053


700 Albany Street, W-500

Boston, MA 02118

Phone: (617) 638-5095


Other research websites:





Research group information:

Please visit: http://www.bumc.bu.edu/ravidlab


Megakaryocytes, Platelets, Stem Cells, Blood Cells, Thrombosis, Vascular Biology, Cell Cycle, Gene Expression


Staining of tubulin in a polyploid megakaryocyte (DJ. McCrann in Dr. Ravid’s lab)

Summary of research interest:

The cells of all blood lineages arise from pluripotent hematopoietic stem cells that reside in the marrow. The bone marrow also contains stem cells of other lineages, including fat, vascular etc. Our research is focused on interrelated projects that bear on mechanisms associated with the development of blood and vascular pathologies: (1) molecular mechanisms involved in the development of bone marrow megakaryocytes into platelets, a process that includes cellular polyploidization prior to platelet fragmentation. Our laboratory identified mechanisms of polyploidy in both megakaryocyte and vascular smooth muscle cells, and found that the degree of polyploidy serves as an excellent biomarker for aging; (2) molecular mechanisms involved in bone marrow megakaryocyte control of the extracellular matrix and myeloproliferative neoplasms; (3) the role of vascular and bone marrow cell adenosine receptors in stem cells biology and vascular function. Transgenic and knockout models are used to assist in exploring mechanisms in vivo. Our laboratory was the first to identify.

Selected publications:

For an updated list, please visit: http://www.bumc.bu.edu/ravidlab