James A. Hamilton
Professor of Physiology and Biophysics
Research Professor of Medicine
Indiana University, Ph.D.
General field of research:
Membrane and Structural Biology; MR imaging of human fat depots and atherosclerosis; Animal models of vulnerable plaque rupture
Affiliations other than medicine:
Evans Center for Interdisciplinary Biomedical Research
Physiology and Biophysics
700 Albany Street, W302 Boston, MA 02218-2526
Phone: (617)-638 5048
700 Albany Street, W302 Boston, MA 02218-2526
Phone: (617)-638 5143
Fax: (617)-638 4041
Other research websites:
Research group information
Su Xu, email@example.com
Eileen R. Krenzel, firstname.lastname@example.org
Ning Hua, email@example.com
Jun Cai, firstname.lastname@example.org
Post Doctoral Fellows:
Kellen Fontanini, Ph.D., email@example.com
Chris Sucato, Ph.D., firstname.lastname@example.org
Zhongjing Chen, Ph.D., email@example.com
Alkystis Phinikaridou, Ph.D., firstname.lastname@example.org
Elena Klimtchuk, Boston University
Jeffrey Simard, Max-Planck Institue, Germany
Volker Kurze, German Patent Office
Johann Wolfgang, Goethe-Universität Frankfurt
Shaoqing Peng, Lambda Solutions, Inc., Waltham, MA
Ji-Kyung Choi, Harvard Medical School/Massachusetts General Hospital
Fengli Zhang, Worcester Poly Tech
Jet Ho, M.D., Private Practice
Wen Guo, Boston University School of Medicine
Frits Kamp, Ludwig-Maximilians-Universität München, Germany
John Boylan, Boston College
Seiichi Era, Gifu University, Japan
Shastri Bhamidipati, USDA
Jonathan Vural, Department of Physiology and Biophysics, Boston University
David H. Croll , Professor of Chemistry and Physics, Regis College, Weston, MA
Donna J. Cabral
Howard Lilly, GE Imaging
Dr. David P. Cistola, Washington University School of Medicine
Ye Qiao, Johns Hopkins
Jason Viereck, M.D. Ph.D., Clinical Practice
Nasi Huang, M.D., Boston University
Kevin Hallock, Ph.D., Boston University
Zifang Guo, M.S., North Carolina University
Fatty Acids; MRI; NMR; Atherosclerosis; Fluorescence; Obesity
Summary of research interest:
Membrane and Structural Biology; Imaging of fat depots and atherosclerotic plaque.
Research in our group is aimed at providing fundamental information relating to heart disease, diabetes, obesity, and diseases related to fatty acid metabolism. An overall goal to is to develop novel approaches to biomedical issues by integrating physical-chemical and physiological/biochemical approaches. In our newest research this is achieved by assembling multi-disciplinary teams to translate basic research into clinical applications. We use physical and instrumental methods (including solution state 13C NMR spectroscopy, solid state and magic angle spinning multinuclear NMR, multidimensional NMR, MR imaging, and fluorescence) that are tailored to the specific questions we are addressing. These techniques are complemented with molecular modeling, molecular biology and other cell biology methods. Two major areas of our research are transport of fatty acids and monitoring atherosclerosis using MRI and NMR spectroscopy. Current efforts are directed towards developing MR imaging to detect vulnerable plaques in humans before they rupture and cause life-threatening events.
Hamilton JA., Qiao Y, Farber A, Semaan E. 2008 Sep. Healing of an asymptomatic carotid plaque ulceration. Circulation; 118(10):e147-8.
Lucke, C., Y. Qiao, H.T.B. Van Moerkerk, J.H. Veerkamp, and J.A. Hamilton. 2006. Fatty-Acid-Binding Protein from the Flight Muscle of Locusta Migratoria: Evolutionary Variations in Fatty Acid Binding. Biochemistry 45 (20):6296-305.
Xie, W., J.A. Hamilton, J.L. Kirkland, B.E. Corkey, and W. Guo. 2006. Oleate-Induced Formation of Fat Cells with Impaired Insulin Sensitivity. Lipids 41 (3):267-71.
Meshulam, T., J.R. Simard, J. Wharton, J.A. Hamilton, and P.F. Pilch. 2006. Role of Caveolin-1 and Cholesterol in Transmembrane Fatty Acid Movement. Biochemistry 45 (9):2882-93.
Guo, W., N. Huang, J. Cai, W.S. Xie, and J.A. Hamilton. 2006. Fatty Acid Transport and Metabolism in Hepg2 Cells. American Journal Of Physiology-Gastrointestinal And Liver Physiology 290 (3):G528-G34.
Ruberg, F.L., J. Viereck, A. Phinikaridou, Y. Qiao, J. Loscalzo, and J.A. Hamilton. 2006. Identification of Cholesteryl Esters in Human Carotid Atherosclerosis by Ex Vivo Image-Guided Proton Mrs. Journal Of Lipid Research 47 (2):310-7.
Simard, J.R., P.A. Zunszain, J.A. Hamilton, and S. Curry. 2006. Location of High and Low Affinity Fatty Acid Binding Sites on Human Serum Albumin Revealed by Nmr Drug-Competition Analysis. Journal Of Molecular Biology 361 (2):336-51.
Technologies available for sharing upon request:
NMR (solution state 13C NMR spectroscopy, solid state and magic angle spinning multinuclear NMR, multidimensional NMR); MRI (12 Tesla)