Noyan Gokce, MD
Professor of Medicine
General field of research:
Cardiology, obesity, echocardiography
Affiliations other than medicine:
Evans Center for Interdisciplinary Biomedical Research
Department of Medicine
88 East Newton St, D-8 Cardiology
Cardiology; Endothelium; Obesity; Echocardiography; Blood Vessels
Summary of research interest:
Our current projects focus on mechanisms of obesity-related cardiovascular disease in human subjects.
Karki S, Farb M, Ngo DTM, Myers S, Puri V, Hamburg NM, Carmine B, Hess DT, Gokce N. Forkhead Box O-1 modulation improves endothelial insulin resistance in human obesity. Arterioscler Thromb Vasc Biol. 2015; 35: 1498-1506
Ngo DTM, Farb MG, Kikuchi R, Karki S, Tiwari S, Bigonia S, Bates D, Hamburg N, Vita JA, Hess DT, Walsh K. Gokce N. Anti-angiogenic actions of VEGF-A165b, an inhibitory isoform of VEGF-A, in human obesity. Circulation 2014; 130: 1072-1080. Editorial commentary in same issue: Leong-Poi, H. “Battle of the bulge: The Ying and Yang of Vascular Endothelial Growth Factor in Obesity”.
Bigornia SJ, Farb MG, Tiwari S, Karki S, Hamburg NM, Vita JA, Hess DT, Lavalley MP, Apovian CM, Gokce N. Insulin status and vascular responses to weight loss in obesity. J Am Coll Cardiol. 2013; 62: 2297-2305. Editorial commentary in same issue: Anderson,T. Insulin as a biomarker to predict vascular protection from weight-loss therapy. Designated for JACC CME activity.
Farb M, Ganley-Leal L, Mott M, Liang Y-M, Ercan B, Widlansky ME, Bigornia S, Fiscale A, Apovian C, Carmine B, Hess DT, Vita JA, Gokce N. Arteriolar function in visceral adipose tissue is impaired in human obesity. Arterioscler Thromb Vasc Biol 2012; 32: 467-473.
Apovian CM, Bigornia S, Mott M, Meyers MR, Ulloor L, Gagua M, McDonnell M, Hess D, Joseph L, Gokce N. 2008. Adipose macrophage infiltration is associated with proinflammatory gene expression and systemic vascular endothelial dysfunction in obese subjects. Arterioscl Thromb Vasc Biol 28: 1654-1659.
Vitseva O, Tanriverdi K, Tchkonia T, Kirkland JL, McDonnell M, Apovian CA, Freedman JA, Gokce N. 2008. Inducible Toll-like receptor and NF-κB regulatory pathway expression in human adipose tissue. Obesity.
Meyers M, Gokce N. 2007. Endothelial dysfunction in obesity: etiologic role in atherosclerosis. Current Opinion in Endocrinology & Diabetes 14: 365-369.
Technologies available for sharing upon request:
Vascular and cardiac ultrasound; PCR; Flow-cytometry; Immunohistochemistry