Jane E. Freedman, MD
BA, Yale University
MD, Tufts University
General field of research:
Thrombosis, Inflammation, Gene Expression
Affiliations other than medicine:
Evans Center for Interdisciplinary Biomedical Research
Pharmacology and Experimental Therapeutics
Whitaker Cardiovascular Institute
700 Albany Street, W507
Research group information
Lea Beaulieu, firstname.lastname@example.org
Kahraman Tanriverdi, email@example.com
Kristine Morin, firstname.lastname@example.org
Olga Vitseva, email@example.com
Subrata Chakrabarti, firstname.lastname@example.org
Muhammad Rizvi, email@example.com
Platelets, Thrombosis, Inflammation, Immunity, Gene Expression, High Throughput
Summary of research interest:
The major research initiatives in the laboratory emphasize the regulation of pathways contributing to atherothrombotic disease and how these factors contribute to acute coronary syndromes. In addition, a second laboratory contains high-throughput equipment for biomarker, DNA, and RNA analyses and uses these facilities in collaboration with clinical and basic studies.
Specific ongoing projects include:
- The role of platelet-dependent thrombosis in unstable cardiovascular syndromes.
- The role of innate immunity and infection in platelet-dependent thrombosis (M. Rizvi).
- The role of innate immunity and infection in megakaryocytic function (L. Beaulieu).
- Platelet imaging (O. Vitseva).
- The role of obesity in thrombosis and gene expression.
- Gene Expression in cardiovascular disease in the Framingham Heart Study.
- The role of miRNA in the regulation of platelet function (K. Tanriverdi, K. Morin).
- The role of the CD40-CD40L interaction in vascular cellular interaction (S. Chakrabarti).
Freedman JE. Molecular Regulation of Platelet-dependent Thrombosis. Circulation. 2005; 12(17):2725-34.
Chakrabarti S, Varghese S, Vitseva O, Tanriverdi K, Freedman JE. CD40 Ligand Influences Platelet Release of Reactive Oxygen Intermediates. Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25:2428-2434.
Chakrabarti S, Blair P, Freedman JE. CD40-40L Signaling in Vascular Inflammation. Journal of Biological Chemistry. 2007;282(25):18307-17.
Freedman JE. Translational Therapeutics at the Platelet Vascular Interface: Oxidative Stress and Platelets. Arteriosclerosis, Thrombosis, and Vascular Biology. 2008 28(3):s11-6.
Blair PS, Rex S, Vitseva O, Beaulieu L, Tanriverdi K, Chakrabarti S, Hayashi C, Genco CA, Iafrati M, Freedman, JE. Stimulation of Toll-like Receptor 2 in Human Platelets Induces a Thrombo-Inflammatory Response Through Activation of Phosphoinositide 3-Kinase. Circulation Research. 2008 104(3):346-54.
Freedman JE, Hylek E. Clopidogrel, genetics, and drug responsiveness. New England Jnl of Medicine. 2009 Jan 22;360(4):411-3.
Rex S, Beaulieu LM, Perlman DH, Vitseva O, Blair PS, McComb ME, Costello CE, Freedman JE. Immune vs. thrombotic stimulation of platelets differentially regulates signaling pathways, intracellular protein-protein interactions, and alpha-granule release. Thrombosis and Haemostasis. In press 2009.
Technologies available for sharing upon request:
High Throughput Gene Expression and Clinical Translational Research Core Facility