Robert Lafyatis, M.D.
Dr. Lafyatis’s research group investigates pathogenic mechanisms in systemic sclerosis. This includes three areas of primary focus. The first is fibrosis and how it is regulated through cytokine mediators such as IL-13 and TGF-beta. The second is innate immunity, and how endogenous and exogenous innate immune stimuli regulate fibrosis. The third area is investigation of how innate immune stimuli regulate vascular injury in systemic sclerosis. The laboratory makes extensive use of and patient derived clinical materials, using immunohistochemistry, RT-PCR and microarray analyses of skin samples to understand pathogenesis, to identify biomarkers and to develop more relevant animal models of systemic sclerosis.