Barbara S. Nikolajczyk, Ph.D.
Associate Professor of Microbiology
B.S. The Ohio State University, Columbus, Ohio
Ph.D. The University of North Carolina at Chapel Hill
Dr. Nikolajczyk is an experienced Molecular Immunologist who has been leading analysis of immune systems changes in obesity and type 2 diabetes patients and DIO mice for the past 5 years. She has led the teams that published the first detailed work showing B cells and T cells from T2D patient blood are pro-inflammatory thus are consistent with murine studies published at about the same time. She has recently published a manuscript detailing the role B cells play in T cell regulation during T2D thus is well versed in analysis of white blood cells. Dr. Nikolajczyk’s established molecular expertise coupled with her more recent experience with metabolic research brings a unique perspective to the analysis of obesity and type 2 diabetes, and how those changes might be exploited to find a cure.
- McDevit, D.C., and B.S. Nikolajczyk. 2006. Changes in immunoglobulin-nucleoprotein complex structure mapped by chromatin immunoprecipitation. Mol Immunol. 43(10):1541-1548. PMID: 16313959
- Liang, M.D., Y. Zhang, D. McDevit, S. Marecki, and B.S. Nikolajczyk. 2006. The Interleukin-1beta Gene is Transcribed from a Poised Promoter Architecture in Monocytes. J. Biol. Chem. 281:9227-9237. PMID: 16439360
- Nikolajczyk, B. 2006. Regulation of Cytokine Transcription in the Context of Chromatin. Arch. Immunol. 54:299-305.
- Nikolajczyk, B.S., S.H. Sardi, J.R. Tumang, and L.M. Ganley-Leal. 2007. Immunoglobulin Kappa Enhancers are Differentially Regulated at the Level of Chromatin Structure. Mol. Immunol. Mar 21; [Epub ahead of print]. PMID: 17382392
- Zhang, Y., S. Saccani, H. Shin, and B.S. Nikolajczyk. 2008. Dynamic protein associations define two phases of IL-1beta transcriptional activation. J. Immunol. 181:503-512. PMID: 18566416
- *Shin, H., Y. *Zhang, M. Jagannathan, H. Hasturk, A. Kantarci, H. Liu, T.E. Van Dyke, L.M. Ganley-Leal, and B.S. Nikolajczyk. 2009. B cells from periodontal disease patients express surface Toll-like Receptor 4. J. Leuk. Biol. 85:648-655. *equal contribution. PMID: 19118102
- Noronha, A.M., Y. Liang, J.T. Hetzel, H. Hasturk, A. Kantarci, A Stucchi, Y. Zhang, B.S. Nikolajczyk, F.A. Farraye, and L.M. Ganley-Leal. 2009. Hyperactivated B cells in human inflammatory bowel disease. J. Leuk. Biol. 86:1007-1016. PMID19589946
- Jagannathan, M., H. Hasturk, Y. Liang, H. Shin, J.T. Hetzel, A. Kantarci, D. Rubin, M.E. McDonnell, T.E. Van Dyke, L.M. Ganley-Leal, and B.S. Nikolajczyk. 2009. TLR cross-talk specifically regulates cytokine production by B cells from chronic inflammatory disease patients. J. Immunol. 183:7461-7470. PMID: 19917698
- Jagannathan, M., M.E. McDonnell, Y. Liang, H. Hasturk, J.T. Hetzel, D. Rubin, A. Kantarci, T.E. Van Dyke, L.M. Ganley-Leal, and B.S. Nikolajczyk. 2010. Toll-like receptors regulate B cell cytokine production in patients with diabetes. Diabetologia 53:1461-1471. PMID: 20383694
- Nikolajczyk, B.S. 2010. B cells as unappreciated mediators of human non-autoimmune inflammatory disease.Cytokine 50:234-242. PMID: 20382544
- Ganley-Leal, LM, Liang, YM, Jagannathan-Bogdan, M, Farraye, FA and Nikolajczyk, BS. 2010. Differential regulation of TLR4 expression in human B cells and monocytes. Mol. Immunol. 48:82-88. PMID: 20956019
- Jagannathan-Bogdan, M, McDonnell, ME, Shin, H, Rehman, Q, Hasturk, H, Apovian, CM, and Nikolajczyk, BS. 2011. Elevated pro-inflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in T2D. J. Immunol. 186:1162-172. PMID: 21169542
- Nikolajczyk, BS, Jagannathan-Bogdan, M, Denis, G. 2012. The Outliers become a Stampede as Immunometabolism Reaches a Tipping Point. Immunol. Rev. 249:253-275. PMID 22889227.
- Belkina, AC, Nikolajczyk, BS, Denis, GV. 2013. BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses. J. Immunol. [Epub ahead of print]. PMID: 23420887.
- DeFuria, J, Belkina, AC, Jagannathan-Bogdan, M, Snyder-Cappione, J, Carr, JD, Nersesova, Y, Markham, D, Strissel, KJ, Watkins, A, Allen, J, Bouchard, J, Torald, G, Jasuja, R, Obin, MS, McDonnell, ME, Apovian, C, Denis, GV and Nikolajczyk, BS. B cells promote inflammation in obesity and type 2 diabetes through regulation of T cell function and an inflammatory cytokine profile (In Press).