Sagar, Manish, M.D.

Medical School: Johns Hopkins University, School of Medicine
Residency training: Johns Hopkins Hospital
Fellowship training: University of Washington

Dr. Manish Sagar is an Associate Professor of Medicine at the Boston University School of Medicine. He was recruited to the Boston University Medical Campus from Brigham and Women’s Hospital in 2012. Dr. Sagar’s research focuses on the pathogenesis of human immunodeficiency virus type 1 heterosexual transmission. He has been a member of the AIDS Clinical Trials Group (ACTG) since 2005. Dr. Sagar has served on numerous committees including NIH study sections and Doris Duke Charitable Foundation Early Career Development Award Review Committee. He is an active member of the Infectious Diseases Society of America (IDSA).

Selected Publications:

Limaye AP, Connolly PA, Sagar M, Fritsche TR, Cookson BT, Wheat LJ, Stamm WE. Transmission of Histoplasma Capsulatum by organ transplantation. N Engl J Med 2000; 343(16):1163-6. [PMID: 11036122]

Sagar M, Lavreys L, Baeten JM, Richardson BA, Mandaliya K, Chohan BH, Kreiss JK, Overbaugh J. Infection with multiple HIV-1 variants is associated with faster disease progression. J Virol 2003; 77(23):12921-6. [PMCID: PMC262567]

Sagar M, Lavreys L, Baeten JM, Richardson BA, Mandaliya K, Achola N, Kreiss JK, Overbaugh J. Identification of modifiable factors that affect the genetic diversity of the transmitted HIV-1 population. AIDS 2004; 18(4):615-9. [PMID: 15090766]

Sagar M, Kirkegaard E, Long EM, Celum C, Buchbinder S, Daar ES, Overbaugh J. HIV-1 diversity at the time of infection is not restricted to certain populations or specific HIV-1 subtypes. J Virol 2004; 78(13):7279-83. [PMCID: PMC421693]

Chohan B*, Lang D*,  Sagar M*, Korber B,  Lavreys L, Richardson B,  Overbaugh J. Selection for HIV-1 envelope glycosylation variants during transmission of certain genetic subtypes and may impact viral RNA levels. J Virol 2005; 79(10):6528-31. [PMCID: PMC1091724] *authors contributed equally to this work

Baeten JM, Lavreys L, Sagar M, Kreiss JK, Richardson BA, Chohan B, Panteleeff D, Mandaliya K, Ndinya-Achola JO, Overbaugh J. Effect of contraceptive methods on natural history of HIV: Studies from the Mombasa cohort. J Aquir Immun Defic Syndr 2005; 38(S1): S18-21. [PMID: 15867603]

Rainwater S, Devange S, Sagar M, Ndinya-Achola J, Mandaliya K, Kreiss JK, Overbaugh J. No evidence for rapid subtype C spread within an epidemic in which multiple subtypes and intersubtype recombinants circulate. AIDS Research and Human Retroviruses. 2005; 21(12):1060-5. [PMID: 16379611]

Sagar M, Kirkegaard E, Lavreys L, Overbaugh J. Diversity in HIV-1 envelope V1-V3 sequences early in infection reflects sequence diversity throughout the HIV-1 genome but does not predict the extent of sequence diversity during chronic infection. AIDS Research and Human Retroviruses 2006; 22(5):430-7. [PMID: 16706620]

Sagar M, Wu X, Lee S, Overbaugh J. HIV-1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection and these modifications affect antibody neutralization sensitivity. Journal of Virology 2006; 80(19):9586-98. [PMCID: PMC1617272]

Tsibris A, Sagar M, Gulick R, Su Z, Hughes M, Greaves W, Subramanian M, Flexner C, Leopold K, Coakley E, Kuritzkes D. In vivo emergence of vicriviroc resistance in an HIV-1 subtype C infected subject. Journal of Virology 2008; 82(16):8210-4. [PMCID: PMC2519584]

Sagar M, Laeyendecker O, Lee S, Gamiel J, Wawer MJ, Gray RH, Serwadda D, Sewankambo NK, Shepherd JC, Toma J, Huang W, Quinn TC. HIVs with signature genotypic characteristics are selected during heterosexual transmission. Journal of Infectious Diseases 2009; 199(4):580-9. [PMCID: PMC2755256]

Paredes R, Sagar M, Marconi VC, Hoh R, Martin JN, Parkin NT, Petropoulos CJ, Deeks SG, Kuritzkes DR. Mechanisms of slow decay of multidrug resistant HIV-1 carrying the M184V mutation in viremic subjects interrupting reverse transcriptase inhibitors. Journal of Virology 2009; 83(4):2038-43. [PMCID: PMC2643770]

Etemad B, Fellows A, Kamat A, Kwambana B, Sagar M. HIV-1 V1-V5 envelope variants from the chronic phase of infection use CCR5 and fuse more efficiently than those from early after infection. Journal of Virology 2009; 83(19):9694-708. [PMCID: PMC2748008]

Sagar M. Clinical implications of new findings in HIV basic research. HIV Therapy 2009; 3(4):351-60. [PMCID: PMC2908407]

Sagar M. HIV-1 Transmission Biology: Selection and Characteristics of the Infecting Viruses. Journal of Infectious Diseases 2010; 202(S2):S289-96. [PMCID: PMC2946383]

Henrich TJ, Tsibris AM, Lewine NR, Konstantinidis I, Leopold KE, Sagar M, Kuritzkes DR. Evolution of CCR5 Antagonist Resistance in an HIV-1 Subtype C Clinical Isolate. JAIDS 2010; 55(4):420-7. [PMCID: PMC3070184]

Sagar M, Akiyama H, Etemad B, Ramirez N, Freitas I, Gummuluru S. Transmembrane Domain Membrane Proximal External Region but not Surface Unit Directed Broadly Neutralizing HIV-1 Antibodies can Restrict Dendritic Cell Mediated HIV-1 Trans Infection. Journal of Infectious Diseases 2012; 205(8):1248-57. [PMCID: PMC3308909 (Available on 2013/4/15)]

Chatziandreou N, Arauz AB, Freitas I, Nyein PH, Fenton G, Mehta SH. Kirk GD, Sagar M. Sensitivity changes over the course of infection increases the likelihood of resistance against fusion but not CCR5 receptor blockers. AIDS Research and Human Retroviruses. Epub ahead of print. [PMID: 22650962]

Redd AD, Collinson-Streng AN, Chatziandreou N, Mullis CE, Laeyendecker O, Martens C, Ricklefs S, Kiwanuka N, Nyein PH, Lutalo T, Kong X, Manucci J, Sewankambo N, Wawer MJ, Gray RH, Porcella SF, Fauci AS, Sagar M, Serwadda D, and Quinn TC. Previously transmitted HIV-1 viral strains are preferentially selected during subsequent sexual transmissions. Journal of Infectious Diseases. (In Press)

Primary teaching affiliate
of BU School of Medicine