Love, John, M.D., Ph.D.
Medical School: Boston University, Boston, MA
Residency training: Internal Medicine, University of Chicago, Chicago, IL
Fellowship training: Infectious Disease, Beth Israel Deaconess Medical Center, Boston, MA
Dr. Love’s research involves the interaction of the human pathogen group A Streptococcus (GAS) with cells encountered early in infection, particularly oropharyngeal keratinocytes and macrophages. Recent observations have found that vitamin D paradoxically makes macrophages more sensitive to GAS infection, in contrast to other studied pathogens. Two GAS toxins, streptolysin O (SLO) and NAD-glycohydrolase, appear to be intimately involved in this atypical outcome. The mechanism of this paradox is under investigation, as it would connect the innate immune response to infection (which generates vitamin D as a paracrine signal) to a potentially deleterious outcome for the host.