HTP Journal Club
The Hematology Training Program Journal Club is held every other Thursday at 4:00 pm in the Evans Biomedical Research Center (EBRC) Building, fourth floor conference Room 428.
Upcoming Journal Club dates:
Thursday, October 29th: Ashley Parks from Dr. Sherr’s Lab. The paper to be discussed will be: ( 2,3,7,8-Tetrachlorodibenzo-p-dioxin Alters the Differentiation of Alloreactive CD8+ T Cells Toward a Regulatory T Cell Phenotype by a Mechanism that is Dependent on Aryl Hydrocarbon Receptor in CD4+ T Cells by Funutake et al).
Recent Journal Clubs:
Dan Dworkis, MD, PhD candidate in Dr. Martin Steinberg’s lab presented on the mechanism for delayed type transfusion reactions in patients with sickle cell anemia. Articles discussed were, “Delayed hemolytic transfusion reaction in sickle cell disease patients: evidence of an emerging syndrome with suicidal red blood cell death” and “To RBC or not to RBC: the role of suicidal death in hemolytic transfusion reactions_02339 1776..1778.”
Ryan Thompson, who is doing his doctoral work in Dr. Tom Gilmore’s lab on the Charles River Campus on NFkB signaling in B cell malignancies, will kick off the new academic year’s HTP Journal Club. He will present an Immunity article by Tsujimoto et al that identifies a unique role for basophils in anaphylaxis. He has also provided us with a Nature Immunology review on basophils.
Ryan Thompson presented on the following articles, “Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma” and “The CARMA1 signalosome links the
signalling machinery of adaptive and innate immunity in lymphocytes.”
Dan Dworkis presented on SNO Hb, as in “Vasoactivity of S-nitrosohemoglobin: role of oxygen, heme, and NO oxidation states.”
John Meyers presented on his work entitled, “PDE4 Inhibitors and Chronic Lymphocytic Leukemia.”
Dr. Liangping Weng presented the following articles, “Recent advances in x-chromosome inactivation” by Edith Heard & “Polycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome” by Jing Zhao, et al.
Representative recent Journal Club articles are:
1) “Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation” by Harvey Lodish and colleagues (PNAS 102: 18962-18967, 2005).
2) “Activating mutations in Notch1 in human acute T cell lymphoblastic leukemia” by Jon Aster and colleagues (Science 306:269-271, 2004).
3) “Bcl10 and MALT1, Independent Targets of Chromosomal Translocation in MALT Lymphoma, Cooperate in a Novel NF-B Signaling Pathway” by Gabriel Nunez and colleagues (JBC 276:19012-19019, 2001).
4) “Cytokine Storm in a Phase 1 Trial of the Anti-CD28 Monoclonal Antibody TGN1412” by Nicki Panoskaltsis and colleagues (NEJM 355: 1018-1028, 2006) and “Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis” by Ralf Gold and colleagues (JEM 202: 445-455, 2005).
5) “A phase II study of bortezomib in relapsed, refractory multiple myeloma” by Kenneth Anderson and colleagues (NEJM 348: 2609-2617, 2003) and “Bortezomib mediates antiangiogenesis in multiple myeloma via direct and indirect effects on endothelial cells.” by Kenneth Anderson and colleagues (Cancer Research 66: 184-191, 2006).
6) “Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412” by Richard Stone and colleagues (Blood, 105:54-60, 2006) and “The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice” by Christian Buske et al (J.Clin.Invest. 115: 2159-2168, 2005).
7) “Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice” by Tasuku Honjo and colleagues (PNAS 104: 1616-1620, 2007) and “Activation-induced deaminase: light and dark sides” by Almudena Ramiro et al (Trends in Molecular Med, 12: 432-439, 2006).
8) “Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma.” By Craig Thompson and colleagues (J Clin Invest 117(2), 326-336, 2007).
9) “Despite inhibition of nuclear localization of NF-B p65, c-Rel, and RelB, 17-b estradiol up-regulates NF-kB signaling in mouse splenocytes: The potential role of Bcl-3.” by Ansar Ahmed and colleagues (J. Immunol. 179:1776-1783, 2007).
10) “Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen proteinase-3” by Ronald J. Falk and colleagues (Nature Medicine 10:72-79. 2004) and “Role of complementary proteins in autoimmunity: an old idea re-emerges with new twists.” by Kathleen McGuire and David S. Holmes (Trends in Immunology 26: 367-372, 2005).
11) “Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability” by Gladwin and colleagues (Blood 109:3088-3098, 2007). “Deconstructing sickle cell disease: Reappraisal of the role of hemolysis in the development of clinical subphenotypes” by Gregory J. Kato, Mark T. Gladwin and Martin H. Steinberg (Blood Reviews 21:37-47, 2007).
12) “Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets” by Weyrich and colleagues (Cell, Vol. 122, 379-391, August 12, 2005) and “The biogenesis of platelets from megakaryocyte proplatelets.” by Italiano and colleagues (J Clin Invest, 115: 3348-3354, 2005).
13) “Transfusion-induced autoantibodies and differential immunogenicity of blood group antigens: a novel hypothesis” by Hillyer and colleagues (Transfusion 47:2189-2196, 2007).
14) “Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor” by Howard Weiner and colleagues (Nature 453: 65-71, 2008).
