2015 Seed Grant Application Open

SEED GRANT: Application Due April 10, 2015

The Genome Science Institute is pleased to announce the availability of one year seed grants ranging up to $20,000; each to enhance genetics and genomics research at Boston University/Boston Medical Center. These grants are intended to provide the resources needed to generate preliminary data prior to the submission of extramural grants (e.g., R01s or P01s).

PURPOSE AND SCOPE: This RFA is intended to stimulate the expansion of genetics and genomics research by enabling the generation of preliminary data and establishing collaborations so they can be convincingly presented in extramural grant applications. We encourage applicants to seek opportunities to

ELIGIBLITY: The RFA is open to all BU faculty on the Medical or Charles River campuses. Joint PIs are allowed. For faculty-level applicants, at least one PI must have been a GSI member for the six months prior to the submission deadline. (Exceptions for new faculty will be considered.) The GSI is open to all BU faculty engaged in genetics and/or genomics research. Please contact gsi@bu.edu to apply.

APPLICATION INSTRUCTIONS:

  1. A two-page application outlining the specific aims, rationale, background (brief) and methodology (brief) of the project.
  2. A one-page summary describing the expertise of the individuals involved.
  3. NIH four-page Biosketch including other support information for all participants.
  4. A detailed budget. Requests can be made only for support staff and/or supplies (i.e., not faculty salaries).
  5. Appropriate IRB/Animal Studies Approval.
  6. Application should be sent to gsi@bu.edu by 5:00 PM on Friday, April 10, 2015.

REVIEW PROCESS: Applications will be reviewed for scientific merit and potential importance in the field of genetics and genomics. Applications will be ranked by the GSI Seed Grant Committee and funding level determined by the GSI directors. A summary of the discussion is available by contacting the seed committee chair after the review. Anyone with a Conflict of Interest with a potential reviewer should make appropriate notes in the application.

REPORTING: Individuals who are funded should appropriately acknowledge support of the GSI in publications and grant applications that arise from this project. A 1-2 page progress report outlining the work carried out, as well as a basic breakdown of how funds have been spent is due 24 months from the date of award. (Although, individuals may be asked to provide this sooner.) Individuals will also be required to give a seminar in the GSI seminar series reporting their findings.

Finally, individuals are required to notify the GSI if any of the work conducted as a result of a GSI seed grant contributes in any way to either a publication or a subsequent award. This allows the GSI to measure the effectiveness of this program.

Faculty Promotions – Associate Professor

Big congratulations are in order for the recent promotions of two GSI faculty members – Dr. Hui Feng and Dr. Valentina Perissi! On May 15, 2019, it was announced that they each have been promoted to Associate Professor status.


The formal BUMC announcement notes each of their research focuses and accomplishments:

Hui Feng, MED, Pharmacology & Experimental Therapeutics and Medicine, established the Zebrafish Genetics and Cancer Therapeutics Laboratory using zebrafish to genetically screen for potential therapeutic targets for human cancers, based on tumor suppressive phenotypes. Dr. Feng’s research studies how cancer cells adapt to cellular and microenvironmental stress and evade immune surveillance in zebrafish. Dr. Feng also collaborates with chemists to develop small molecule compounds to inhibit MYC-driven cancer aggressiveness. Current extramural funding includes an existing R01 and foundation grants (including one from the American Cancer Society) and has published articles in high-impact journals such as Nature, Nature Cell BiologyCancer Cell and Leukemia.

Click here for more information on my research and background!

 

Valentina Perissi, MED, Biochemistry, is a molecular and cell biologist whose NIH- and DOD-supported work investigates the interplay between inflammation and metabolism in the context of breast cancer and obesity-induced insulin resistance and diabetes. Dr. Perissi’s research investigates the mechanism of its actions in adipogenesis and has uncovered a critical, non-transcriptional role for GPS2 in regulating the enzymatic activity of the TRAF2/CIAP1/Ubc13 ubiquitin conjugating complex. The Perissi lab uses tissue-specific mouse models to study how the different components of the NCoR complex contribute to broadly regulate the cellular responses to external stimulation by acting in different cellular compartments to modulate hormonal and inflammatory pathways. Dr. Perissi is also the Co-Director of the Adipose Tissue Biology and Nutrient Metabolism Core  in the Boston Nutrition Obesity Research Center.

Click here for more information on my research and background!


The Genome Science Insitute is very proud to have members that are dedicated to advancing genetics and genomics research while also recognizing them for their vast, overall accomplishments. We can’t wait to see what your futures have in store and look forward to your future scientific accomplishments!

GSI Seminar Speaker, May 22, Len Zon

“Pathways regulating hematopoietic stem cell self-renewal and migration”

Professor of Pediatric Medicine at Harvard Medical School, Director of Stem Cell Program at Boston Children’s Hospital

2PM in the Conte Building, K103

GSI Workshop Competition 2019 Winners

The Genome Science Institute is excited to announce the winners of our first ever Workshop Competition! For full details on the competition and our partners that made the competition possible, check out our official announcement here!

  1. Digital Droplet PCR Award – “Quantitative measurement of intact HIV provirus in latent reservoir of aging HIV populations”
    Alex Olson, Carolyn Coote, and Andrew Henderson, Ph.D.
    BMC and BUSM Dept of Medicine and Microbiology

  2. scRNA-seq Award – “A transcriptomic analysis of induced pluripotent stem cell-derived conventional dendritic cells”
    Ian Rifkin, M.D. Ph.D. and Gustavo Mostoslavsky, M.D. Ph.D.
    BUSM Dept of Microbiology, Dept of Medicine, CREM

  3. scRNA-seq Award – “Role of microRNAs in channeling cell fate determination”
    Daniel Cifuentes, Ph.D.
    BUSM Dept of Biochemistry

  4. scRNA-seq Award – “Single Cell Analysis of Skull Formation”
    Shannon Fisher, M.D. Ph.D.
    BUSM Dept of Pharmacology and Experimental Therapeutics

  5. scRNA-seq Award – “Role of GPS2 in Adipose Tissue Adaptation to Metabolic Stress”
    Valentina Perissi, Ph.D.
    BUSM Dept of Biochemistry

 

GSI Seminar Speaker, Mar 20, John Kim

“Small RNAs and non-canonical RBPs in worms and yeast”

Associate Professor at Johns Hopkins University, Department of Biology

3PM in the Conte Building, K103

GSI Seminar Speaker, Jan 16, Frank Slack

“MicroRNAs for Personalized Medicine in Cancer”

Director, HMS Initiative for RNA Medicine, Shields Warren Mallinckrodt Professor of Medical Research, BIDMC Cancer Center, Harvard Medical School

3PM in the Conte Building, K103

BUSM GSI 2019 Workshop Competition Announcement

The BUSM Genome Science Institute, in collaboration with the BU Single-Cell Sequencing Core, is sponsoring two workshops this Spring 2019, providing the BUMC and BU research community a chance to explore two developing areas of genomic experiments for generating preliminary data for future grant proposals. 

Both workshops are limited competitions for labs to submit an experimental proposal by March 15, 2019.  Winners selected by the GSI Review Panel would receive a set of deeply subsidized reagents from the GSI to conduct Droplet Digital PCR (ddPCR) or a pilot Single-Cell RNA Sequencing experiment (scRNASeq). Three awards for ddPCR (up to $2400 reagent value per lab) and three awards for scRNA-Seq (up to $9000 in reagent value per lab) will be made to the best-chosen proposals.

On February 20, the GSI will host a seminar by Biorad scientists on the theory and workflow of Droplet Digital PCR on the QX200 instrument housed on K-building, 2nd floor.  There will also be an info session discussing the scope of the Single Cell RNA Sequencing Pilot experiments.  These workshop awards will allow labs to conduct significant but focused pilot experiments, and details will be discussed at the February seminar and updated on this website.

If your lab is interested in ddPCR, please enter your interest information at this link.

Two-page long proposals must be submitted to the GSI website by March 15, and winners would be announced promptly and will be required to submit samples for experimentation by the end of the Spring term. Results from pilot experiments should then be presented at the GSI Research Symposium in November 2019. 

Click here for details on the proposal criteria.

Click here for the ddPCR Applications Guide.

 

For further questions, please email the GSI at gsi@bu.edu.

Save the Date! 2018 GSI Research Symposium: November 15th

Save the Date, November 15th 2018!

The Annual GSI Research Symposium is an interdisciplinary event emphasizing research in Genetics and Genomics. Participation in the poster session and attendance at the GSI Symposium is open to all Boston area researchers with interests that emphasize these disciplines. Abstracts will be selected for oral presentation distinction and additional prizes will be awarded for the best posters in multiple categories. Participation in the oral presentations and poster prizes are open to all undergraduate students, graduate students in MA, MSc, DSc, PhD, MD, MPH and MD/PhD programs, and postdoctoral fellows.

There will be three categories for participants. To apply, please fill out the online Submission Form. Abstracts are due October 19th by 5pm.

The Genome Science Institute 2018 Annual Research Symposium will be held  November 15th 2018 in the Hiebert Lounge from Noon-5 p.m.

Noon-12:30 p.m. – Lunch and Networking
12:30-2:00 – Posters
2:00-4:00 – Talks
4:00-4:30 – Awards

Poster Session: Poster presentations are open to all Boston area researchers including undergraduate students, graduate students, postdoctoral fellows and faculty.
Oral Presentations: Presenters will be invited from abstracts submitted by undergraduate and graduate students, and postdoctoral fellows.
Awards: Prizes will be given for top student and postdoctoral posters and presentations.
Genetics and Genomics Graduate Studies at BU: Representatives from BU graduate programs that provide training in Genetics and Genomics will be available.
Vendor Tables: Representatives from companies providing Genetics and Genomics related products and services will present their latest technology.

 

Call for Abstracts: 2018 GSI Research Symposium due October 19th

The Annual GSI Research Symposium is an interdisciplinary event emphasizing research in Genetics and Genomics. Participation in the poster session and attendance at the GSI Symposium is open to all Boston area researchers with interests that emphasize these disciplines. Abstracts will be selected for oral presentation distinction and additional prizes will be awarded for the best posters in multiple categories. Participation in the oral presentations and poster prizes are open to all undergraduate students, graduate students in MA, MSc, DSc, PhD, MD, MPH and MD/PhD programs, and postdoctoral fellows.

There will be three categories for participants. To apply, please fill out the online Submission Form. Abstracts are due October 19th by 5pm.

 

For more information about the Research Symposium, please visit its informational website here.

Ingenuity Pathway Analysis (IPA) Training and CLC bio Seminar

QIAGEN Bioinformatics at Boston University Medical Campus
Wednesday, April 11th
Ingenuity Pathway Analysis (IPA) and CLC bio Seminar

Session 1:  11:00 TO 12:00

CLC product for secondary analysis

Overview of Application, Importing NGS read data, QC & Pre-processing

  • De novo assembly – Genomes & Transcriptomes. Characterizing Contigs, Joining & Finishing
  • Mapping/Alignment to Reference, Variant Calling, Annotation & Filtering
  • RNA Seq Analysis Workflow & Tools
  • Overview of Microbial Modules (Finishing & Microbial Genomics)

CLC Biomedical Workbench & Ingenuity Variant Analysis

  • Prebuilt intuitive pipeline for your human DNA-seq data that allows you to quickly go from reads or called variants to identifying and prioritizing the casual variants.

 12:00 To 12:30- Pizza Lunch

Session 2:  12;30 TO 2:00

IPA for insightful data analysis and interpretation

  • Biological interpretation of gene (including RNAseq), protein and metabolic expression data
  • Pathway involvement and change
  • Effected biological processes
  • Causal regulators and their directional effect on genes, functions and diseases across multiple time points or doses.
  • Explore IPA’s knowledge and discovery tools that allow you to relate the most recent literature findings to your research.
  • Questions and Answers

Session 3- 2:00 TO 4:00

Available for individual sessions by appointment, email Amar below

Please register ahead of time so we have an accurate

count for lunch

Location: BUMC Instructional Building L214
Presenter:QianDong,Phd
ApplicationScientist
Register: Amar Swami
Amar.Swami@qiagen.com

 

Congratulations to the Winners of the 2017 GSI Research Symposium

pic website

The Directors, faculty, and staff of the Genome Science Institute would like to thank all who attended the Ninth Annual GSI Research Symposium and helped to make it a success! We extend special thanks to those faculty members who participated as poster judges this year, and to the vendors upon whose generous support this event depends.

Following a very successful event, the Directors of the Genome Science Institute at Boston University School of Medicine are pleased to announce the winners of the 2017 GSI Research Symposium!

Oral Award Recipients
Virginia Fisher Department of Biostatistics, BUSPH A Hierarchical Approach to Genetic Fine Mapping Incorporating Functional Annotation
Anoush Calikyan Undergraduate College Of Arts and Sciences, BUSM Modeling Familial Partial Lipodystrophy Dunnigan Type 2 with CRISPR Technology
Ruben Esse Department of Biochemistry, BUSM Embryonic H379 Methylation of Enhancers Poises them for Future Tissue-Specific Activation and Prevents their Epigenetic Silencing
Hongjae Sunwoo Department of Molecular Biology, MGH Repeat E Anchors Xist RNA to the Inactive X Chromosome Territory Through Interaction with CIZ1

Poster Award Recipients
-Timothy Norman, CSF1R+ progenitors con-tribute to postnatal pulmonary lymphatic endo-thelium
Eve Byington, Discovery of Topologically Associating Domains using RNA-Seq datasets in human brain
Dmitry Kretov, Dicer-independent miR-451 interferes with Canonical microRNA-biogenesis pathway
Ekaterina Gushchanskaia, Effect of small RNAs on chromatin landscape

We extend our sincere congratulations to this year’s winners. Given both the quantity and quality of the abstracts and posters submitted this year, choosing just 5 speakers and 5 poster award winners was by no means an easy task.

We hope that all who attended enjoyed the Symposium, and look forward to seeing you again in November 2018!