Alumni

Constantina Christodoulou, Ph.D.

Constantina received her Ph.D. in Genetics and Genomics in 2012.  She is currently an Investigator II at Novartis Institutes for BioMedical Research.

Publications from thesis work:

Christodoulou C, Kotton DN. Are embroyonic stem and induced pluripotent stem cells the same of different? Implications for their potential therapeutic use. Cell Cycle 2012 Jan 1; 11(1): 5-6.

Christodoulou C, Longmire TA, Shen SS, Bourdon A, Sommer CA, Gadue P, Spira A, Gouon-Evans V, Murphy GJ, Mostoslavsky G, Kotton DN.  Mouse ES and iPS cells can form similar definitive endorderm despite differences in imprinted genes. J Clin Invest 2011 Jun; 121(6): 2313-25.

Sommer CA, Sommer AG, Longmire TA, Christodoulou C, Thomas DD, Gostissa M, Alt FW, Murphy GJ, Kotton DN, Mostoslavsky G.  Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single exisable vector. Stem Cells 2010 Jan; 28(1): 64-74.

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Catalina Perdomo Ph.D.

Catalina received her Ph.D. in Genetics and Genomics in 2012.  She is currently a Research Associate at Princeton University.

Publications from thesis work:

Perdomo C, Spira A, Schembri F.  MiRNAs as regulators of the response to inhaled environmental toxins and airway carcinogenesis. Mutat Res 2011 Dec 1; 717(1-2): 32-7.

Wu J, Qian J, Li C, Kwok L, Cheng F, Liu P, Perdomo C, Kotton D, Vaziri C, anderlind C, Spira A, Cardoso WV, Lu J.  miR-129 regulates cell proliferation by downregulating Cdk6 expression. Cell Cycle 2010 May; 9(9): 1809-18.

Schembri F, Sridhar S, Perdomo C, Gustafson AM, Zhang X, Ergun A, Lu J, Liu G, Zhang X, Bowers J, Vaziri C, Ott K, Sensinger K, Collins JJ, Brody JS, Getts R, Lenburg ME, Spira A.  MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci U S A 2009 Feb 17; 106(7): 2319-24.

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Florin Craciun, Ph.D.

Florin received his Ph.D. in Genetics and Genomics in 2011.  He is currently a Senior Scientist at Sanofi.

Publications from thesis work:

Craciun FL, Schuller ER, Remick DG.  Early enhanced local neutrophil recruitment in peritonitis-induced sepsis improves bacterial clearance and survival. J Immunol 2010 Dec 1; 185(11): 6930-8.

Osuchowski MF, Craciun FL, Schuller E, Sima C, Gyurko R, Remick DG.  Untreated type 1 diabetes increases sepsis-induced mortality without inducing a prelethal cytokine response. Shock 2010 Oct; 34(4): 369-76.

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Ihn Young Song,  Ph.D.

Ihn received her Ph.D. in Genetics and Genomics in 2010.  She is currently a Postdoctoral Fellow in the Department of Genetics and Genomics at the University of California, San Francisco.

Publications from thesis work:

Barkley LR, Song IY, Zou Y, Vaziri C.  Reduced expression of GINS complex members induces hallmarks of premalignancy in primary untransformed human cells. Cell Cycle, 2009 May 15; 8(10): 1577-88.

Ohashi E, Hanafusa T., Kamei K, Song I, Tomida J, Hashimoto H, Vaziri C, Ohmori H.  Identification of a novel REV1-interacting motif necessary for DNA polymerase kappa function. Genes Cells., 2009 Feb; 14(2): 101-11.

Foy RL, Song IY, Chitalia VC, Cohen HT, Saksouk N, Cayrou C, Vaziri C, Cote J, Panchenko MV.  Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex. J Biol Chem., 2008 Oct 24; 283(43): 28817-26.

Tomida J, Masuda Y, Hiroaki H, Ishikawa T, Song I, Tsurimoto T, Tateishi S, Shiomi T, Kamei Y, Kim J, Kamiya K, Vaziri C, Ohmori H, Todo T.  DNA damaged-induced ubiquitylation of RFC2 subunit of replication factor C complex. J Biol Chem., 2008 Apr 4; 283(14): 9071-9.

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Chen Khuan Wong, Ph.D.
Chen’s research focuses on studying the association between Smad4 defect and metastasis, a major cause of cancer death, in colon cancer.  Smad4 is a tumor suppressor which localizes to 18q, a chromosomal region with frequent loss of heterozygosity in advanced disease stage.  Smad4 plays a central role in the TGF-beta antigrowth signaling pathway and its loss of function is associated with poor prognosis and chemotherapeutic resistance in colon cancer.  Currently, I am working on identifying Smad4 interacting transcription factors and cofactors, which may serve as targets that become alternatively inactivated, culminating in loss of metastasis suppression.

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Gerald Stanvitch, Ph.D.

Jerry received his Ph.D. in Genetics and Genomics in 2010.  He is currently the Senior Director of Scientific Content at Aptitude Health.

Publications from thesis work:

Stanvitch G, Moore LL.  cin-4, a gene with homology to topoisomerase II, is required for centromere resolution by cohesin removal from sister kinetochores during mitosis. Genetics, 2008 Jan; 178(1): 83-97.

Moore LL, Stanvitch G, Roth MB, Rosen D.  HCP-4/CENP-C promotes the prophase timing of centromere resolution by enabling the centromere association of HCP-6 in Caenorhabditis elegans. Mol Cell Biol, 2005 Apr; 25(7): 2583-92.

 

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Tovah Day Ph.D.

Tovah received her Ph.D. in Genetics and Genomics in 2009.  She is currently a Postdoctoral Fellow in the Weinstock Lab at the Dana Farber Cancer Institute.

Publications from thesis work:

Day T, Vaziri C. HPV E6 oncoprotein prevents recovery of stalled replication forks independently of p53 degradation Cell Cycle 2009 Jul 15; 8(14):2138.  Epub 2009 Jul 15.

Liu P, Barkley LR, Day T, Bi X, Slater DM, Alexandrow MG, Nasheurer HP, Vaziri C. The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism. J Biol Chem. 2006 Oct 13; 281(41):30631-44. Epub 2006 Aug 15.

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Kelly (Graham) Seyed, Ph.D.

Kelly received her Ph.D. in Genetics and Genomics in 2009.  She is currently the Managing Director at McAllister and Quinn.

 

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Panagiotis Papageorgis  Ph.D.

Panagiotis received his  Ph.D. in Genetics and Genomics in 2009.  He is currently an Associate Professor and Dean at European University Cyprus

Publications from thesis work:

Papageorgis P, Lambert AW, Ozturk S, Gao F, Pan H, Manne U, Alekseyev YO, Thiagalingam A, Abdolmaleky HM, Lenburg M, Thiagalingam S. Smad signaling is required to maintain epigenetic silencing during breast cancer progression. Cancer Res 2010 Feb 1; 70(3):968-78.

Gao F, Ponte JF, Levy M, Papageorgis P, Cook NM, Ozturk S, Lambert AW, Thiagalingam A, Abdolmaleky HM, Sullivan BA, Thiagalingam S. hBub1 negatively regulates p53 mediated early cell death upon mitotic checkpoint activation. Cancer Biol Ther 2009 Apr; 8(7):548-56.

Gao F, Ponte JF, Papageorgis P, Levy M, Ozturk S, Lambert AW, Pan H, Chinnappan D, Cheng KH, Thiagalingam A, Abdolmaleky HM, Thiagalingam S. hBub1 deficiency triggers a novel p53 mediated early apoptotic checkpoint pathway in mitotic spindle damaged cells.Cancer Biol Ther 2009 Apr; 8(7):627-35.

Pan H, Gao F, Papageorgis P, Abdolmaleky HM, Faller DV, Thiagalingam S. Aberrant activation of gamma-catenin promotes genomic instability and oncogenic effects during tumor progression.Cancer Biol Ther 2007 Oct; 610):1638-43.

 

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Dorothy Pazin Ph.D.

Dorothy received her Ph.D. in Genetics and Genomics in 2009.  She is currently an Alliance Manager at Broad Insititute of MIT and Harvard.

Publications from thesis work:

Lee HJ, Pazin DE, Kahlon RS, Correa SM, Albrecht KH. Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern. Dev Dyn 2009 Apr; 238(4):812-25.

Liu P, Pazin DE, Merson RR, Albrecht KH, Vaziri C. The developmentally-regulated Smoc2 gene is repressed by aryl-hydrocarbon receptor (Ahr) signaling. Gene 2009 Mar 15; 433(1-2):72-80. Epub 2008 Dec 24.

Lam AL, Pazin DE, Sullivan BA. Control of gene expression and assembly of chromosomal subdomains by chromatin regulators with antagonistic functions. Chromosoma 2005 Sep; 114(4):242-51. Epub 2005 Oct 15.

 

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Courtney Kronenthal, Ph. D.

Courtney received her Ph.D. in Genetics and Genomics in 2007. She is currently working with the Genomes2People project at Bringham and Womens.

Publications:

Mintzer JL, Kronenthal CJ, Kelly V, Seneca M, Butler G, Fecenko-Tacka K, Altamuro D, Madore SJ. Preparedness for a natural disaster: how coriell planned for hurricane sandy. Biopreserv Biobank. 2013 Aug;11(4):216-20. doi: 10.1089/bio.2013.0035. Epub 2013 Aug 6.

Kronenthal C, Delaney SK, Christman MF. Broadening research consent in the era of genome-informed medicine. Genet Med. 2012 Apr;14(4):432-6. doi: 10.1038/gim.2011.76. Epub 2012 Mar 15.

 

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Damien Slater, Ph.D.

Damien received his Ph.D. in Genetics and Genomics in 2007. He is currently a Senior Scientist at Foundation Medicine.

Publications from thesis work:

Liu P, Barkley LR, Day T, Bi X, Slater DM, Alexandrow MG, Nasheuer HP, Vaziri C. The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism. J Biol Chem. 2006 Oct 13;281(41):30631-44. Epub 2006 Aug 15.

Bi X, Barkley LR, Slater DM, Tateishi S, Yamaizumi M, Ohmori H, Vaziri C. Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest. Mol Cell Biol. 2006 May;26(9):3527-40.

Bi X, Slater DM, Ohmori H, Vaziri C. DNA polymerase kappa is specifically required for recovery from the benzo[a]pyrene-dihydrodiol epoxide (BPDE)-induced S-phase checkpoint. J Biol Chem. 2005 Jun 10;280(23):22343-55. Epub 2005 Apr 6.

 

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Dana Lau-Corona
Dana currently is a Researcher in the Boston Area after graduating with her Ph.D. in Genetics and Genomics in May of 2018.

Publications:

Lau-Corona D, Suvorov A, Waxman D. Feminization of Male Mouse Liver by Persistent Growth Hormone Stimulation: Activation of Sex-Biased Transcriptional Networks and Dynamic Changes in Chromatin States. Mol Cell Biol. 2017 Sep;

Connerney J. Lau-Corona D, Rampersaud A, Waxman D. Activation of Male Liver Chromatin Accessibility and STAT5-Dependent Gene Transcription by Plasma Growth Hormone Pulses. Endocrinology. 2017 Feb; 158(5): 1386-1405.

Lau-Corona D, Kershenobich D, Gutierrez-Reyes G. The impact of genetic variability on liver disease in the Hispanic/Latin-American population. Autoimmunity.2011 May; 44(7):549-554. doi: 10.3109/08916934.2011.592883. Epub 2011 Aug 24.

Kershenobich D, Lau-Corona D, Kershenovich R, Gutierrez-Reyes G. Management of Alcoholic Liver Disease: An Update. Alcoholism: Clinical & Experimental Research. 2011 Feb; 35(5):804-805. Epub 2011 April 26.

Keri Dame
Keri Dame is utilizing her education as a Research Fellow (ORISE) at the FDA. She graduated with her Ph.D. in Genetics & Genomics in September of 2017 after conducting research under Dr. Laertis Ikonomou.

Publication(s):

Dame K, Cincotta S, Lang AH, Sanghrajka RM, Zhang L, Choi J, Kwok L, Wilson T, Kandula M, Monti S, Hollenberg AN, Mehta P, Kotton DN, Ikonomou L. Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells through Transient, Developmental Stage-Specific Overexpression of Nkx2-1. CellPress. 2016 Dec; 8(2):216-225. Epub 2017 Feb 2.

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Carly Garrison
Carly graduated from the program in December 2015 and shortly after started a Postdoctoral Research Fellowship at Fred Hutch where she focuses on cancer biomarker discovery for early detection, recurrence and response to treatment using patient plasma. During her time at BU, conducted research under Avrum Spira. 

Publication(s):

Garrison CB, Lastwika KJ, Zhang Y, Li CI, Lampe, PD. Proteomic Analysis, Immune Dysregulation, and Pathway Interconnections with Obesity. J Proteome Res., 2016 Oct; 16(1):274-287. Epub 2017.

Perdomo C, Campbell JD, Gerrein J., Tellez CS, Garrison CB, Walser TC, Drizik E, Si J, Gower AC, Vick J, Anderlind C, Jackson GR, Mankus C, Schembri F, O’Hara C, Gomperts BN, Dubinett SM, Hayden P, Belinsky SA, Lenburg ME, Spira A. MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis. PNAS. 2013 Nov. 110(47):18946-18951.

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Elyse Kozlowski
In 2016, Elyse graduated from BUSM with a Ph.D. in Genetics & Genomics and currently works as a Program Manager for the All of Us Research Program through University of Arizona.

Publication(s):

Pino P, Sebastian S, Kim EA, Bush E, Brochet M, Volkmann K, Kozlowski E, Llinas M, Billker O, Soldati-Favre D. A tetracycline-repressible transactivator system to study essential genes in malaria parasites. Cell Host Microbe. 2012 Dec 13; 12(6):824-24; doi: 10.1016/j.chom.2012.10.016.

Jones MR, Blahna MT, Kozlowski E, Matsuura KY, Ferrari JD, Morris SA, Powers JT, Daley GQ, Quinton LJ, Mizgerd JP. Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival. PLoS Genet. 2012; 8(11):e1003105. doi: 10.1371/journal.pgen.1003105. Epub 2012 Nov 29.

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Akshaya Ramesh
Akshaya graduated in 2017 from the GPGG and has moved across the country for a Postdoctoral Fellowship in the Department of Neurology at the University of California, San Francisco (UCSF).

Publication(s):

Ramesh A, Darko S, Hua A, Overman G, Ransier A, Francica JR, Trama A, Tomaras GD, Yahnes BF, Douek DC, Kepler TB. Structure and Diversity of the Rhesus Macaque Immunoglobulin Loci through Multiple De Novo Genome Assemblies. Front Immunol. 2017 Oct. https://doi.org/10.3389/fimmu.2017.01407.

Francica JR, Sheng Z, Zhang Z, Nishimura Y, Shingai M, Ramesh A, Keele BF, Schmidt SD, Flynn BJ, Darko S, Lynch RM, Yamamoto T, Matus-Nicodemos R, Wolinksy D, NISC Comparative Sequencing Program, Nason M, Valiante NM, Malyala P, De Gregorio E, Barnett SW, Singh M, O’Hagan DT, Koup RA, Mascola JR, Martin MA, Kepler TB, Douek DC, Shapiro L, Seder RA. Analysis of immunoglobulin transcripts and hypermutation following SHIV(AD8) infection and protein-plus-adjuvant immunization. Nat Commun. 2015 Apr; 6:6565. doi: 10.1038/ncomms7565.

Small ST, Ramesh A, Bun K, Reimer L, Thomsen E, Baea M, Bockarie MJ, Siba P, Kzura JW, Tisch DJ, Zimmerman PA. Population genetics of the filarial worm wuchereria bancrofti in a post-treatment region of Papua New Guinea: insights into diversity and life history. PLoS Negl Trop Dis. 2013 Jul; 7(7):e2308. doi: 10.1371/journal.pntd.0002308. Print 2013.

Ramesh A, Small ST, Kloos ZA, Kazura JW, Nutman TB, Serre D, Zimmerman PA. The complete mitochondrial genome sequence of the filarial nematode Wuchereria bancrofti from three geographic isolates provides evidence of complex demographic history. Mol Biochem Parasitol. 2012 May; 183(1):32-41. doi: 10.1016/j.molbiopara.2012.01.004. Epub 2012 Feb 1.

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