By Dr. Pietro Cottone

PCottone

*Sabino V, *Cottone P, Koob GF, Steardo L, Lee MJ, Rice KC, Zorrilla EP. Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats. Psychopharmacol (Berl). 2006; 189(2):175-86. *These two authors equally contributed to the publication. http://www.ncbi.nlm.nih.gov/pubmed/17047935

*Cottone P, *Sabino V, Steardo L, Zorrilla EP. FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability. Neuropsychopharmacol. 2007; 32(5): 1069-81. *These two authors equally contributed to the publication. http://www.ncbi.nlm.nih.gov/pubmed/17077811

*Sabino V, *Cottone P, Steardo L, Schimidhammer H, Zorrilla  EP. 14-methoxymetopon, a highly poten LM opioid agonist, biphasically affects ethanol intake in Sardinian alcohol-preferring rats. Psychopharmacol (Berlin). 2007; 192(4): 537-46. *These two authors equally contributed to the publication.

*Cottone P, *Sabino V, Nagy TR, Rivier JE, Coscina V, Zorrilla EP. Feeding microstructure in diet-induced obesity susceptible and resistant rats: comparative central effects of urocortin 2. J Physiol. 2007; 583 (Pt 2): 487-504. *These two authors equally contributed to the publication. http://www.ncbi.nlm.nih.gov/pubmed/17627984

Esposito G, Scuderi C, Savani C, Steardo Jr. L, De Filippis D, Cottone P, Iuvone T, Cuomo V, Steardo L Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression. Brit J Pharmacol. 2007; 151(8): 1272-9.

http://www.ncbi.nlm.nih.gov/pubmed/17592514

George O, Ghozlan S, Azar MR, Cottone P, Zorrilla EP, Parson LH, O’Dell LE, Richardson HN, Koob GF. CRF-CRF1 system activation medicates withdrawal-induced anxiety-like behavior and increases in nicotine self-administration in nicotine dependent rats. Proc Natl Acad Sci U S A. 2007; 104(43):17198-203. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822665/

*Cottone P, *Sabino V, Steardo L, Zorrilla EP. Intermittent preferred food access reduces the reinforcing efficacy of chow in rats. Am J Physiol Regul Integr Comp Physiol. 2008; 295(4): R1066-76. *These two authors equally contributed to the publication. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576087/

*Cottone P, *Sabino V, Steardo L, Zorrilla EP. Opioid-dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food. Neuropsychopharmacology. 2008 Feb;33(3):524-35. *These two authors equally contributed to the publication. http://www.ncbi.nlm.nih.gov/pubmed/17443124

Greenwell TN, Walker BM, Cottone P, Zorrilla EP, Koob GF. The alpha(1) adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration. Pharmacol Biochem Behav. 2009; 91(3): 295-302. http://www.ncbi.nlm.nih.gov/pubmed/18703080

*Cottone P, *Sabino V, Steardo L, Zorrilla EP. Consummatory, anxiety-related and metabolic adaptations in female rats with alternating access to preferred food. Psychoneuroendocrinol. 2009; 34(1): 38-49. *These two authors equally contributed to the publication. http://www.ncbi.nlm.nih.gov/pubmed/18842344

*Sabino V, *Cottone P, Zhao Y, Iyer MR, Steardo Jr. L, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. The sigma receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neuropsychopharmacol. 2009 May; 34(6): 1842-93. 2008, October 22 (Epub ahead of print]. *These two authors equally contributed to the publication. http://www.ncbi.nlm.nih.gov/pubmed/18946467

*Sabino V, *Cottone P, Parylak SL, Steardo L, Zorrilla EP. Sigma-1 receptor knockout mice display a depressive-like phenotype. Behav Brain Res. 2009 Mar 17; 198(2): 472-6. Epub 2008 Nov 30. *These two authors equally contributed to the publication. http://www.ncbi.nlm.nih.gov/pubmed/19100292

Greenwell TN, Funk CK, Cottone P, Richardson HN, Chen SA, Rice KC, Zorrilla EP, Koob GF. Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long-, but not short-access rats. Addict Biol. 2009 Apr; 14 (2): 130-43. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748834/

*Cottone P, *Sabino V, Roberto M, Bajo M, Pockros L, Frihauf J, Fekete EM, Steardo L, Rice KC, Grigoriadis D, Conti B, Koob GF, Zorrilla EP. CRF system recruitment mediates dark side of compulsive eating. Proc Natl Acad Sci U S A. 2009 Nov; 106(47): 20016-20. *These two authors equally contributed to the publication.  http://www.pnas.org/content/early/2009/11/06/0908789106.abstract

Fonareva I, Spangler E, Cannella N, Sabino V, Cottone P, Ciccocioppo R, Zorrilla EP, Ryabinin AE. Increased Perioculomoor Urocortin 1 immunoreactivity in genetically selected alcohol preferring rats. Alcohol Clin Exp Res. 2009 Nov; 33 (11): 1956-65

*Sabino V, *Cottone P, Zhao Y, Steardo L, Koob GF, Zorrilla EP. Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist. Psychopharmacol (Berl). 2009; 205(2): 327-335. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748837/

Roberto M, Cruz MT, Gilpin NW, Sabino V, Schweitzer P, Bajo M, Cottone P, Madamba S, Stouffer DG, Zorrilla EP, Koob GF, Siggins GR, Parsons LH. CRF-induced amygdala GABA release plays a key role in alcohol dependence. Biol Psychiatry. 2010 May; 67(9): 831-9. http://www.ncbi.nlm.nih.gov/pubmed/20060104

Repunte-Canonigo V, Berton F, Cottone P, Reifel-Miller A, Roberts A, Morales M, Francesconi W, Sanna, PP. A potential role for adiponectin receptor 2 (AdipoR2) in the regulation of alcohol intake. Brain Res. 2010 Jun; 1339: 11-7.   http://www.ncbi.nlm.nih.gov/pubmed/20380822

*Sabino V, *Cottone P, Blasio A, Iyer MR, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats. Neuropsychopharmacol. 2011 May; 36(6): 1207-18. *These two authors equally contributed to the publication. http://www.ncbi.nlm.nih.gov/pubmed/21346735

Fekete E, Zhao Y, Szücs A, Sabino V, Cottone P, Rivier J, Vale W, Koob G, Zorrilla E. Systemic urocortin 2, but not urocortin 1 or stressin(1) -A, suppresses feeding via CRF(2) receptors without malaise and stress. Br J Pharmacol. 2011 Dec; 164(8): 1959-1975.

Blasio A, Narayan AR, Kaminski BJ, Steardo L, Sabino V, Cottone P. A modified adjusting delay task to assess impulsive choice between isocaloric reinforcers in non-deprived male rats: effects of 5-HT(2A/C) and 5-HT (1A) receptor agonists. Psychopharmacol (Berl). 2012 Jan;219(2):377-86 “Special Issue on Impulsivity and Compulsivity” http://www.ncbi.nlm.nih.gov/pubmed/21989803

Iemolo A*, Valenza M*, Tozier L, Knapp CM, Kornetsky C, Steardo L, Sabino V, Cottone P. Withdrawal from chronic, intermittent access to a highly palatable food induces depressive-like behavior in compulsive eating rats Behav Pharmacol. 2012 Sep;23(5-6):593-602. “Special Issue on Pharmacological Approaches to Feeding Behaviour and Eating Disorders” *These two authors equally contributed to the publication. http://www.ncbi.nlm.nih.gov/pubmed/22854309

Parylak SL*, Cottone P*, Sabino V, Rice KC, Zorrilla EP. Effects of CB1 and CRF1 receptor antagonists on binge-like eating in rats with limited access to a sweet fat diet: lack of withdrawal-like responses. Physiology and Behavior. 2012 Jul 6;107(2):231-242 *These two authors equally contributed to the publication. http://www.ncbi.nlm.nih.gov/pubmed/22776620

Cottone P, Wang X, Park JW, Valenza M, Blasio A, Kwak J, Iyer MR, Steardo L, Rice KC, Hayashi T, Sabino V. Antagonism of Sigma-1 receptors blocks compulsive–like eating. Neuropsychopharmacol. 2012 37(12):2593-604. http://www.ncbi.nlm.nih.gov/pubmed/22713906

Cottone P, Iemolo A, Narayan AR, Kwak J, Momaney D, Sabino V. The uncompetitive NMDA receptor antagonists ketamine and memantine preferentially increase the choice for a small, immediate reward in low-impulsive rats. Psychopharmacol (Berl). In Press http://www.ncbi.nlm.nih.gov/pubmed/23104264

Sabino V, Kwak J, Rice K, Cottone P. Pharmacological characterization of the 20% alcohol intermittent access model in Sardinian alcohol-preferring rats: a model of binge-like drinking. Alcohol Clin Exp Res. In Press http://www.ncbi.nlm.nih.gov/pubmed/23126554

Blasio A, Steardo L, Sabino V, Cottone P. Opioid system in the medial prefrontal cortex mediates binge-like eating Addict Biol. In Press http://www.ncbi.nlm.nih.gov/pubmed/23346966

Cottone P, Sabino V, Nagy TR, Coscina DV, Levin BE, Zorrilla EP. Centrally administered urocortin 2 decreases gorging on high-fat diet in in both diet induced obesity-prone and -resistant rats. Int J Obesity. In Press

Sabino V, Narayan AR, Zeric T, Steardo L, Cottone P. mTOR activation is required for the anti-alcohol effect of ketamine, but not memantine, in alcohol-preferring rats. Behav Brain Res. In Press http://www.ncbi.nlm.nih.gov/pubmed/23466691

Dore R, Valenza M, Wang X, Rice KC, Sabino V, Cottone P. The inverse agonist of CB1 receptor SR141716 blocks compulsive eating of palatable food. Addict Biol. In Press