Robert C. Green, M.D., MPH
Professor of Neurology, Medicine and Epidemiology
2000 M.P.H.(Epidemiology), Emory University School of Public Medicine, Atlanta, GA
1980 M.D. (Medicine), University of VA Medical School, Charlottesville, VA
1976 B.A. (Biology), Amherst College, Amherst, MA
Other Appointments
Co-Director, BU Alzheimer’s Disease Clinical and Research Program
Research Interests
Dr. Green joined the faculty of the Boston University School of Medicine in 1999. He is co-director of Boston University’s Alzheimer’s Disease Clinical and Research Program, and is the Clinical Director of the NIA-funded Alzheimer’s Disease Center. Dr. Green is the author of over 130 publications, serves on a number of advisory, editorial and grant review boards, and is immediate past President of the Society for Behavioral and Cognitive Neurology. He has been voted one of America’s “Best Doctors” by his peers.
Dr. Green’s research interests are in early and preclinical detection, treatment and prevention of Alzheimer’s disease. He is a co-Principal Investigator on Boston University’s NIH-funded MIRAGE Study (Multi-Institutional Research in Alzheimer’s Genetic Epidemiology), a consultant on the NIH-funded Cache County Memory and Aging Study and is the Boston site director of the NIH-funded ADAPT Study (Alzheimer’s Disease Anti-Inflammatory Prevention Trial), one of the first large-scale intervention trials to prevent the development of Alzheimer’s disease in at-risk family members. Dr. Green is also Principal Investigator and Director of the REVEAL Study (Risk Evaluation and Education for Alzheimer’s disease) a multi-center project funded by the National Human Genome Research Institute and the National Institute on Aging to develop genetic risk assessment strategies for individuals at risk for Alzheimer’s disease.
Dr. Green graduated from Amherst College and the University of Virginia School of Medicine before completing a residency in neurology at Harvard Medical School’s Longwood Neurology Program. Following this, he completed research fellowships in Behavioral Neurology and Neurophysiology at the Beth Israel Hospital and Children’s Hospital in Boston, winning both the William B. Lennox Research Fellowship and the Wilder Penfield Research Fellowship. Dr. Green obtained additional training in Epidemiology, receiving a Masters in Public Health from the Rollins School of Public Health at Emory University.
Peer-reviewed publications
Mielke MM, Rosenberg PB, Tschanz J, Cook L, Corcoran C, Hayden KM, Norton M, Rabins PV, Green RC, Welsh-Bohmer KA, Breitner JCS, Munger R, Lyketsos CG: Vascular factors predict rate of functional decline in Alzheimer’s disease. Neurology, in press.
Cuenco KR, Green RC, Zhang J, Lunetta K, Erlich PM, Cupples LA, Farrer LA, DeCarli C: Magnetic resonance imaging traits in siblings discordant for Alzheimer disease. J Neuroimaging, in press.
Jefferson AL, Wong S, Gracer TS, Ozonoff A, Green RC , Stern RA. Geriatric performances on the Boston Naming Test-30 item even version. Applied Neuropsychology. in press.
Lunetta KL, Erlich PM, Cuenco KT, Cupples LA, Green RC, Farrer LA, DeCarli C: Heritability of Magnetic Resonance Imaging (MRI) Traits in Alzheimer Disease Cases and Their Siblings in the MIRAGE Study. Alzheimer Dis Assoc Disord, 21(2):85-91, 2007.
Lyketsos CG, Breitner JCS, Green RC, Martin BK, Piantadosi S, Sabbagh M: Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial (ADAPT). Neurology, 68(21):1800-8 , 2007.
Onyike CU, Sheppard JME, Tschanz JT, Mayer LS, Green RC… Lyketsos CG: Epidemiology of apathy in older adults: The Cache County Study. J Ger Psychiatry, 15(5):365-75, 2007.
Rogaeva E, Meng Y, Lee JH, Gu Y-J, Kawarai T, Katayama T, Erlich PM, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Cupples LA, Green RC….St. George-Hyslop, P: The sortilin-related receptor SorLA is associated with Alzheimer’s disease. Nature Genetics, 39:168-77, 2007.
ADAPT Research Group. Cardiovascular and cerebrovascular events in the randomized, controlled Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT). PloS Clinical Trials, 1(7):e33, 2006 .
Green RC , Dekosky ST: Primary prevention trials in Alzheimer’s disease. Neurology 67:S2-5, 2006.
Nair A, Green RC: Alzheimer’s disease at 100 years. Practical Neurology, 5:22-29, 2006.
Gooding HC, Linnenbringer E, Burack J, Roberts JS, Green RC, Biesecker BB. (2006) Desire for genetic susceptibility testing for Alzheimer disease: Perceived threat and the need for information and control in the REVEAL Study. Patient Educ Couns 64:259-267
Binetti G, Benussi L, Roberts S, Villa A, Pasqualetti P, Sheu C-F, Gigola L, Lussignoli G, Dal Forno G, Barbiero L, Corbellini, Green RC, Rossini PM, Ghidoni R. (2006) Areas of intervention for genetic counselling of dementia: Cross-cultural comparison between Italians and Americans. Patient Education & Counseling
Akomolafe A, Lunetta KL, Erlich PM, Cupples LA, Baldwin CT, Huyck M, Green RC, Farrer LA. (2006) Genetic association between endothelial Nitric Oxide Synthase (NOS3) and Alzheimer disease. Clinical Genetics, 70:49-56.
Akomolafe A, Beiser A, Meigs JB, Au R, Green RC, Farrer LA, Wolf PA, Seshadri S. (2006) Diabetes mellitus and risk of developing Alzheimer disease. Arch Neurol 63:1551-1555.
Tsai DH, Green RC, Benke KS, Silliman RA, Farrer LA (2006) Predictors of subjective memory complaint in cognitively normal relatives of patients with Alzheimer’s disease. Journal of Neuropsychiatry and Clinical Neuroscience, 18:384-388.
Eckert SL, Katzen H, Roberts JS, Barber M, Ravdin LD, Relkin NR, Whitehouse PJ, Green RC. (2006) Recall of disclosed Apolipoprotein E genotype and lifetime risk estimate for Alzheimer’s disease: The REVEAL Study. Genetics in Medicine 8:746-751.
Erlich PM, Lunetta KL, Cupples LA, Huyck M, Green RC, Baldwin CT, Farrer LA. (2006) Polymorphisms in the PON gene cluster are associated with Alzheimer disease. Hum Mol Genetics, 15:77-85.
LaRusse S, Roberts JS, Marteau TM, Katzen H, Linnenbringer EL, Barber M, Whitehouse P, Quaid K, Brown T, Green RC, Relkin NR. (2005) Genetic susceptibility testing versus family history-based risk assessment: impact on perceived risk of Alzheimer disease. Genetics in Medicine, 7:48-53.
Hurley A, Harvey R, Roberts JS, Wilson-Chase C, Lloyd S, Prest J, Lock M, Horvath KJ., & Green RC. (2005). Genetic susceptibility for Alzheimer’s disease: Why did adult offspring seek testing? American Journal of Alzheimer’s Disease and Other Dementias, 20(6), 374-81.
Roberts JS, Cupples LA, Relkin NR, Whitehouse PJ, & Green RC. (2005). Genetic risk assessment for adult children of people with Alzheimer’s disease: The Risk Evaluation and Education for AD (REVEAL) Study. Journal of Geriatric Psychiatry & Neurology, 18, 250-55.
Henderson VW, Benke KS, Green RC, et al: Postmenopausal hormone therapy and Alzheimer’s disease risk: Interaction with age. JNNP 2005; 76: 103-105.
Marteau T, Roberts JS, LaRusse SA, Green RC: Genetic susceptibility testing versus family history-based risk assessment: Impact upon perceived risk of Alzheimer’s disease. Risk Analysis, 25(2):397-404, 2005.
Zick CD, Matthews C, Roberts JS, Cook-Deegan, R, Pokorski RJ, Green RC: Genetic susceptibility testing for Alzheimer’s disease and its impact upon health insurance behavior. Health Affairs, 24(2):483-90, 2005.
Cupples LA … Green RC: Estimating risk curves for first-degree relatives of patients with Alzheimer’s disease: The REVEAL Study. Genetics in Medicine, 6:192-196, 2004.
Roberts JS … Green RC: Who seeks genetic susceptibility testing for Alzheimer’s disease? Findings from a multi-site, randomized clinical trial. Genetics in Medicine, 6:197-203, 2004.
Hipps YG… Green RC: Differences between African Americans and whites in their attitudes toward genetic testing for Alzheimer’s disease. Genetic Testing 7:39-44, 2003.
Green RC , et al: Depression as a risk factor for Alzheimer’s disease: The MIRAGE Study. Arch Neurol, 60:753-759, 2003.
Roberts JS.. Green RC: Differences in perceptions of AD between African Americans and white Americans. ADAD 17:19-26, 2003.
Bachman DL, Green RC, et al: Comparison of Alzheimer’s disease risk factors in White and African American families: The MIRAGE Study. Neurology, 60:3072-1374, 2003.
Roberts JS… Green RC: Reasons for seeking genetic susceptibility testing among first-degree relatives of people with Alzheimer’s disease. ADAD, 17:86-93, 2003.
Green RC , Cupples LA, Go R, et al: Risk of dementia among White and African American relatives of Alzheimer’s disease patients. JAMA, 287:329-336, 2002.
Graff-Radford N, Green RC, et al: Association between APOE and Alzheimer’s in African Americans. Arch Neurol 59:594-600, 2002.
Green RC: Genetic susceptibility testing for Alzheimer’s disease: Has the moment arrived? Alz’s Care Quarterly, 3:208-14, 2002.
Books
Green RC : Diagnosis and Management of Alzheimer’s Disease and Other Dementias, Professional Communications, Inc., New York, First Edition, 2001; Second Edition, 2005.
Read C, Green RC, Smyer R (eds ): Genetic Technology and the Future, Johns Hopkins Press, Baltimore, MD, in press.
