Boston University Medical Campus
Biomedical Genetics

Clinton T. Baldwin, Ph.D.

Broadly speaking, the goal of the research I conduct is the identification of genes that cause diseases in humans. Current techniques for isolating disease genes involve the use of statistical methods on pedigrees of related affected and unaffected individuals. These methods are often computationaly intensive since the scale of the human genome is so large and even a small representation of the 3 billion or so bases that comprise an individuals genetic identity can be insufficient. It is thus one of the goals of the lab to try to utilize the computational facilities available at Boston University to provide a solution for this problem both in terms of increasing the accuracy of results and decreasing the time needed to produce them.

T Cuenco K, Lunetta KL, Baldwin CT, McKee AC, Guo J, Cupples LA, Green RC, St George-Hyslop PH, Chui H, DeCarli C, Farrer LA; MIRAGE Study Group. Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease. Arch Neurol. 2008 Dec;65(12):1640-8.

Sedgewick AE, Timofeev N, Sebastiani P, So JC, Ma ES, Chan LC, Fucharoen G, Fucharoen S, Barbosa CG, Vardarajan BN, Farrer LA, Baldwin CT, Steinberg MH, Chui DH. BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies. Blood Cells Mol Dis. 2008 Nov-Dec;41(3):255-8. Epub 2008 Aug 8.

Cuenco KT, Green RC, Zhang J, Lunetta K, Erlich PM, Cupples LA, Farrer LA, DeCarli C; MIRAGE Study Group. Magnetic resonance imaging traits in siblings discordant for Alzheimer disease. J Neuroimaging. 2008 Jul;18(3):268-75.

Sebastiani P, Wang L, Nolan VG, Melista E, Ma Q, Baldwin CT, Steinberg MH. Fetal hemoglobin in sickle cell anemia: Bayesian modeling of genetic associations. Am J Hematol. 2008 Mar;83(3):189-95.

Sebastiani P, Zhao Z, Abad-Grau MM, Riva A, Hartley SW, Sedgewick AE, Doria A, Montano M, Melista E, Terry D, Perls TT, Steinberg MH, Baldwin CT. A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples. BMC Genet. 2008 Jan 14;9:6.

Ma Q, Wyszynski DF, Farrell JJ, Kutlar A, Farrer LA, Baldwin CT, Steinberg MH. Fetal hemoglobin in sickle cell anemia: genetic determinants of response to hydroxyurea. Pharmacogenomics J. 2007 Dec;7(6):386-94. Epub 2007 Feb 13.

Sebastiani P, Nolan VG, Baldwin CT, Abad-Grau MM, Wang L, Adewoye AH, McMahon LC, Farrer LA, Taylor JG 4th, Kato GJ, Gladwin MT, Steinberg MH. A network model to predict the risk of death in sickle cell disease. Blood. 2007 Oct 1;110(7):2727-35. Epub 2007 Jun 28.

Terry DF, Wyszynski DF, Nolan VG, Atzmon G, Schoenhofen EA, Pennington JY, Andersen SL, Wilcox MA, Farrer LA, Barzilai N, Baldwin CT, Asea A. Serum heat shock protein 70 level as a biomarker of exceptional longevity. Mech Ageing Dev. 2006 Nov;127(11):862-8. Epub 2006 Oct 6.

Meng Y, Baldwin CT, Bowirrat A, Waraska K, Inzelberg R, Friedland RP, Farrer LA. Association of polymorphisms in the Angiotensin-converting enzyme gene with Alzheimer disease in an Israeli Arab community. Am J Hum Genet. 2006 May;78(5):871-7. Epub 2006 Mar 16.

Erlich PM, Lunetta KL, Cupples LA, Huyck M, Green RC, Baldwin CT, Farrer LA; MIRAGE Study Group. Polymorphisms in the PON gene cluster are associated with Alzheimer disease. Hum Mol Genet. 2006 Jan 1;15(1):77-85. Epub 2005 Nov 30.

Russo CJ, Melista E, Cui J, DeStefano AL, Bakris GL, Manolis AJ, Gavras H, Baldwin CT. Association of NEDD4L ubiquitin ligase with essential hypertension. Hypertension. 2005 Sep;46(3):488-91. Epub 2005 Aug 15.

Sebastiani P, Ramoni MF, Nolan V, Baldwin CT, Steinberg MH. Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia. Nat Genet. 2005 Apr;37(4):435-40. Epub 2005 Mar 20.

Zhou XF, Cui J, DeStefano AL, Chazaro I, Farrer LA, Manolis AJ, Gavras H, Baldwin CT. Polymorphisms in the promoter region of catalase gene and essential hypertension. Dis Markers. 2005;21(1):3-7.

Cui J, Melista E, Chazaro I, Zhang Y, Zhou X, Manolis AJ, Baldwin CT, Destefano AL, Gavras H. Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. J Hypertens. 2005 Jan;23(1):55-62.

Erlich PM, Cui J, Chazaro I, Farrer LA, Baldwin CT, Gavras H, DeStefano AL. Genetic variants of WNK4 in whites and African Americans with hypertension. Hypertension. 2003 Jun;41(6):1191-5. Epub 2003 Apr 28. DeStefano AL, Gates GA, Heard-Costa N, Myers RH, Baldwin CT. Genomewide linkage analysis to presbycusis in the Framingham Heart Study. Arch Otolaryngol Head Neck Surg. 2003 Mar;129(3):285-9.

Farrer LA, Bowirrat A, Friedland RP, Waraska K, Korczyn AD, Baldwin CT. Identification of multiple loci for Alzheimer disease in a consanguineous Israeli-Arab community. Hum Mol Genet. 2003 Feb 15;12(4):415-22.

Farrer LA, Friedland RP, Bowirrat A, Waraska K, Korczyn A, Baldwin CT. Genetic and environmental epidemiology of Alzheimer’s disease in arabs residing in Israel. J Mol Neurosci. 2003;20(3):207-12.

Joost O, Wilk JB, Cupples LA, Harmon M, Shearman AM, Baldwin CT, O’Connor GT, Myers RH, Gottlieb DJ. Genetic loci influencing lung function: a genome-wide scan in the Framingham Study. Am J Respir Crit Care Med. 2002 Mar 15;165(6):795-9.

Baldwin CT, Cupples LA, Joost O, Demissie S, Chaisson C, Mcalindon T, Myers
RH, Felson D. Absence of linkage or association for osteoarthritis with the vitamin D receptor/type II collagen locus: the Framingham Osteoarthritis Study. J Rheumatol. 2002 Jan;29(1):161-5.

Baldwin CT, Hoth C, Amos J, da Silva E, Milunsky A. An exonic mutation in the HuP2 paired domain gene causes Waardenburg’s syndrome. Nature. 1992 Feb 13;355(6361):637-8.

Baldwin C, Lipsky N, Hoth C, Mamuya W, Milunsky A. Mutations in PAX3 associated with Waardenburg syndrome type I. Hum Mutat. 1994;3(3):205-11.

Baldwin C, Farrer L, Adair R, Dharmavaram R, Jimenez S, Anderson L. Linkage of early-onset osteoarthritis and chondrocalcinosis to human chromosome 8q. Am J Hum Genet. 1995 Mar;56(3):692-7.
Baldwin C, Hoth C, Macina R, Milunsky A. Mutations in PAX3 that cause Waardenburg syndrome type I: ten new mutations and review of the literature. Am J Med Genet. 1995 Aug 28;58(2):115-22. Review.

Baldwin C, Bonne-Tamir B, Weiss S, DeStefano A, Adair R, Franklyn B, Kidd K, Korostishevsky M, Farrer L. Linkage of congenital, recessive deafness (DFNB4) to chromosome 7q31 and evidence for genetic heterogeneity in the Middle Eastern Druze population. Hum Mol Genet. 1995 Sep;4(9):1637-42.

Bonne-Tamir B, DeStefano A, Briggs C, Adair R, Franklyn B, Weiss S, Korostishevsky M, Frydman M, Baldwin C, Farrer L. Linkage of congenital recessive deafness (gene DFNB10) to chromosome 21q22.3. Am J Hum Genet. 1996 Jun;58(6):1254-9.

Baima J, Nicolaou M, Schwartz F, DeStefano A, Bursztyn M, Handy D, Manolis A, Gavras I, Farrer L, Baldwin C, Gavras H. Evidence for linkage between essential hypertension and a putative locus on human chromosome 17. Hypertension. 1999 Jul;34(1):4-7.

Baldwin C, Cupples LA, Joost O, Demissie S, Chaisson C, McAlindon T, Myers R, Felson D. Absence of linkage or association for osteoarthritis with the vitamin D receptor/type II collagen locus: the Framingham Osteoarthritis Study. J Rheumatol. 2002 Jan;29(1):161-5.

DeStefano AL, Gates GA, Heard-Costa N, Myers RH, Baldwin C. Genomewide linkage analysis to presbycusis in the Framingham Heart Study. Arch Otolaryngol Head Neck Surg. 2003 Mar;129(3):285-9.

Farrer LA, Bowirrat A, Friedland RP, Waraska K, Korczyn AD, Baldwin C. Identification of multiple loci for Alzheimer disease in a consanguineous Israeli-Arab community. Hum Mol Genet. 2003 Feb 15;12(4):415-22.

Erlich PM, Cui J, Chazaro I, Farrer LA, Baldwin C, Gavras H, DeStefano AL. Genetic variants of WNK4 in Whites and African Americans With hypertension. Hypertension. 2003 Jun;41(6):1191-5. Epub 2003 Apr 28.