Carolien Panhuysen, Ph.D.
![[Carolien Panhuysen]](http://www.bumc.bu.edu/genetics/files/2008/11/carolien_final.jpg)
Research Assistant Professor, Dept of Medicine (Genetics Program), BUSM
1996-97 Post-doctoral Fellowship, Center for the Genetics of Asthma and Complex Diseases, University of Maryland, Baltimore, MD
1996 Ph.D. Genetics and Natural History of Obstructive Pulmonary Disease*
1990 M.D. Medical School, Rijks Universiteit Groningen, The Netherlands
1982 V.W.O St. Maartens College, Haren, The Netherlands
Research Interests
Dr. Panhuysen’s research interests focus on the genetic epidemiologic analyses of complex traits. The use of these analytical methods such as analysis of familial correlations, segregation analysis, and linkage analysis, are designed to unravel evidence for the genetic basis of the disease with the purpose to get a better understanding of the etiology of the disease. Dr. Panhuysen has been actively involved in a genetic epidemiological study of a cohort of Dutch asthma families for the past 10 years. She is currently involved in genetic studies on Inflammatory Bowel Disease, Substance dependencies, Uterine Leiomyomata (fibroids) and Age-related Macular Degeneration (AMD).
Amelung PJ, Panhuysen CIM, Postma DS, Levitt RC, Koëter GH, Francomano CA, Bleecker ER, Meyers DA. Atopy, asthma and bronchial hyperresponsiveness: Exclusion of linkage to markers on chromosomes 11q and 6p. Clin Exp Allergy 1992;22:1077-84.
Meyers DA, Postma DS, Panhuysen CIM, Xu J, Amelung PJ, Levitt RC, Bleecker ER. Evidence for a locus regulating total serum IgE levels mapping to chromosome 5. Genomics 1994;23:464-70.
Meyers DA, Postma DS, Panhuysen CIM, Amelung PJ, Levitt RC and Bleecker ER. Genetics of asthma and COPD. In: Bronchitis V: Proceedings of the fifth international symposium on advances in understanding asthma and COPD. Eds. Postma DS and Gerritsen J. Van Gorcum & Company, The Netherlands. 1994;172-83.
Postma DS, Panhuysen CIM, Kerstjens H. Chronic complications of asthma. In: Manual of asthma management. Eds. O’Byrne P, Thompson N. WB Saunders Company Ltd., London. 1995;739-764.
Panhuysen CIM , Bleecker ER, Koëter GH, Meyers DA, Postma DS. Dutch approach on the study of the genetics of asthma. Clin Exp Allergy 1995;25:35-9.
Xu J, Levitt RC, Panhuysen CIM, Postma DS, Taylor EW, Amelung PJ, Holroyd KJ, Bleecker ER, Meyers DA. Evidence for two unlinked loci regulating total serum IgE levels. Am J Hum Genet 1995;57:425-30.
Xu J, Taylor EW, Panhuysen CIM, Prenger VL, Koskela R, Kiemeney B, LaBuda MD, Maestri NE, Meyers DA. Two locus approach of segregation and linkage analysis in the study of complex traits. Genet Epidemiol 1995;12:825-30.
Postma DS, Panhuysen CIM, Gerritsen J, Koëter GH. Asthma from childhood to adulthood. In: XVI European Congress of Allergology and Clinical Immunology. Proceedings I. Eds. Basomba A, Sastre J. Monduzzi Editore. 1995;331-6.
Postma DS, Bleecker ER, Amelung PJ, Holroyd JK, Panhuysen CIM, Meyers DA, Levitt RC. Localization of bronchial hyperresponsiveness near a major gene for atopy on chromosome 5q31-q33. New Eng J Med 1995;333:894-900.
Panhuysen CIM , Meyers DA, Postma DS, Levitt RC, Bleecker ER. The genetics of asthma and atopy. Allergy 1995;50:863-69.
Panhuysen CIM , Meyers DA. Genetic Regulation of Total Serum IgE Levels, In: Genetics of asthma. Eds Ligget S, Meyers DA. Marcel Dekker, Inc., New York Chapter. 1996;24:511-23.
Panhuysen CIM , Vonk JM, Koëter GH, Schouten JP, Bleecker ER, Postma DS. Adult patients may outgrow their asthma; A 25 year follow-up study. Am J Resp Crit Care Med 1997;153(4):1267-72.
Xu J, Panhuysen CIM, Taylor EW, Wiesch DG, Meyers DA. Empirical evaluation of genome scans for linkage of a quantitative trait associated with a complex disorder. Genet Epidemiol 1997;14(6):927-32.
Amelung PJ, Postma DS, Panhuysen CIM, Meyers DA, Bleecker ER. Susceptibility loci regulating total serum IgE levels, bronchial hyperresponsiveness, and clinical asthma map to chromosome 5q. Chest 1997;111(6 Suppl):S77-S78.
Panhuysen CIM , Bleecker ER, Koëter GH, Meyers DA, Postma DS. Characterization of obstructive airway disease in family members of probands with asthma. An algorithm for the diagnosis of asthma. Am J Respir Crit Care Med 1998;157(6 Pt 1):1734-42.
Wyszynski DF, Panhuysen CIM. Parent-of-origin effect in families with alcoholism. In: Goldin L, Amos CI, Chase GA, Goldstein AM, Jarvik GP, Martinez MM, Suarez BK, Weeks DE, Wijsman EM, and MacCluer JW. Genetic Analysis Workshop 11: Analysis of genetic and environmental factors in common diseases. Genetic Epidemiology 1999;17(Suppl 1):S409-S413.
Brant SR, Panhuysen CIM, Bailey-Wilson JE, Rohal PM, Lee S, Mann J, Ravenhill G, Kirschner BS, Hanauer SB, Cho JH, Bayless TM. Linkage heterogeneity for the IBD1 locus in Crohn’s disease pedigrees by disease onset and severity. Gastroenterology 2000;119(6):1483-90.
The IBD International Genetics Consortium. International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled dataset: Crohn’s disease and chromosome 16. Am J Hum Genet 2001;68:1165-7.
Meigs JB, Panhuysen CIM, Myers RH, Wilson PWF, Cupples,A. A genome-wide scan for loci linked to plasma levels of glucose and hemoglobin A1c in a community-based sample of Caucasian pedigrees: the Framingham offspring study. Diabetes 2002;51(3):833-40.
CIM Panhuysen , LA Cupples, PWF Wilson, AG Herbert, RH Myers, JB Meigs. A genome scan for loci linked to quantitative insulin traits in persons without diabetes: the Framingham Offspring Study. Diabetologia, 46:579-587, 2003.
S Karamohamed, J Volcjak, J Liu, C Shoemaker, CI Panhuysen, JB Meigs, P Wilson, LA Cupples, A Herbert. Polymorphisms in the insulin degrading enzyme gene are associated with type 2 diabetes mellitus in men from the NHLBI Framingham Heart Study. Diabetes, 52: 1562-1567, 2003.
Vonk JM, Jongepier H, Panhuysen CIM, Schouten JP, Bleecker ER, Postma DS. Risk factors associated with the presence of irreversible airflow limitation and reduced transfer coefficient in patients with asthma after 26 years of follow up. Thorax, 58(4):322-327, 2003.
AG Yip, Q Ma, M Wilcox, CI Panhuysen, J Farrell, LA Farrer, DF Wyszynski. Search for genetic factors predisposing to atherogenic dyslipidemia BMC Genetics 2003, 4(Suppl 1):S100 (1 December 2003)
MA Wilcox, DF Wyszynski, CI Panhuysen, Q Ma, A Yip, J Farrell, LA Farrer. Empirically derived phenotypic subgroups – qualitative and quantitative trait analyses. BMC Genetics 2003, 4(Suppl 1):S15
Wyszynski DF, Panhuysen CI, Ma Q, Yip AG, Wilcox MA, Erlich P, Farrer LA. Genome-wide screen for heavy alcohol consumption. BMC Genet;4:S1062003.
ST Brant, CIM Panhuysen, D Nicolae, DM Reddy, DK Bonen, R Karaliukas, L Zhang, E Swanson, LW Datta, T Moran, G Ravenhill, RH Duerr, J-P Achkar, AS Karban, JH Cho. MDR1 Ala893 polymorphism is associated with inflammatory bowel disease., Am J Hum Genet; 73:1282-1292,2003.
A Karban, T Okazaki, CI Panhuysen, T Gallegos, JJ Potter, JE Bailey-Wilson, MS Silverberg, RH Duerr, J Cho, PK Gregersen, Y Wu, J-P Achker, T Dassopoulos, E Mezey, TM Bayless, FJ Nouvet, SR Brant. Functional Annotation of a Novel NFKB1 Promoter Polymorphism that Increases Risk for Ulcerative Colitis. Hum Mol Genet 13(1): 35-45, 2003.
MM Barmada, SR Brant, DL Nicolae, J-P Achkar, CI Panhuysen, TM Bayless, JH Cho. A genome scan in 260 inflammatory bowel disease-affected relative pairs. Inflamm Bowel Dis; 10:15-22, 2004.
A Karban, M Waterman, CI Panhuysen, R Dresner Pollak , S Nesher, L Datta, B Weiss, A Suissa, R Shamir, SR Brant, R Eliakim. NOD2/CARD15 genotype and phenotype differences between Ashkenazi and Sephardic Jews with Crohn’s Disease. Am J Gastroenterol; 99(6):1134-1140, 2004.
B Voetsch, KS Benke, CI Panhuysen, BP Damasceno, J Loscalzo. The combined effect of paraoxinase promotor and coding region polymorphisms on the risk of arterial ischemic stroke among young adults. Arch Neurol, 61:351-356, 2004
KL Gross, CIM Panhuysen, MS Kleinman, H Goldhammer , ES Jones, N Nassery, EA Stewart, and CC Morton. Involvement of Fumarate Hydratase in Non-syndromic Uterine Leiomyomata: Genetic Linkage Analysis and FISH Studies. Genes, Chromosomes & Cancer; 41:183–190, 2004.
AO Edwards, R Ritter, KJ Able, A Manning, C Panhuysen, LA Farrer. Complement Factor H Polymorphism and age-related macular degeneration. Science, 308(5720):421-424, 2005.
J Gelernter, C Panhuysen, R Weiss, K Brady, V Hesselbrock, B Rounsaville, J Poling, M Wilcox, L Farrer, HR Kranzler. Genomewide linkage scan for cocaine dependence and related traits: Significant linkages for a cocaine-related trait and cocaine-induced paranoia. Am J Med Genet; 136:45-52, 2005.
Kalayasiri R, Kranzler HR, Weiss R, Brady K, Gueorguieva R, Panhuysen C, Yang BZ, Farrer L, Gelernter J, Malison RT. Risk factors for cocaine-induced paranoia in cocaine-dependent sibling pairs. Drug and Alcohol Dependence. in press 2005.
Kalayasiri R, Kranzler HR, Weiss R, Brady K, Gueorguieva R, Panhuysen C, Yang BZ, Farrer L, Gelernter J, Malison RT. Risk factors for cocaine-induced paranoia in cocaine-dependent sibling pairs. Drug and Alcohol Dependence. in press 2006 [Epub ahead of print].
Gelernter J, Panhuysen C, Wilcox M, Hesselbrock V, Rounsaville B, Poling J, Weiss R, Sonne S, Zhao H, Farrer L, Kranzler HR. Genome-wide linkage scan for opioid dependence and related traits. Am J Hum Genet 2006, In Press.
Panhuysen CI, Karban A, Knodle Manning A, Bayless TM, Duerr RH, Bailey-Wilson JE, Epstein Jr. EH, Brant SR. Identification of Genetic Loci for Basal Cell Nevus Syndrome and Inflammatory Bowel Disease in a Single Large Pedigree. Hum Genet 2006, In Press.
