Representative Publications

Papadopoulos, G., Kramer, C., Slocum, C., Weinberg, E., Hua, N., Gudino, C.V., Hamilton, J.A., C.A. Genco.  A Mouse Model for Pathogen-Induced Chronic Inflammation at Local and Systemic Sites. Journal of Visualized Experiments (JoVE). 2014. In Press.

Slocum CS, Coats R, Hua N, Kramer C, Papadopolous G, Weinberg EO, Gudino CV, Hamilton JA, Darveau RP, Genco CA. Distinct lipid A moieties contribute to pathogen-induced site-specific vascular inflammation. PLoS pathogens. 2014 July 2014; 10(7): e1004215. Full Text

Shaik-Dasthagirisaheb YB, Huang N, Weinberg EO, Shen SS, Genco CA, Gibson FC.  Aging and contribution of MyD88 and TRIF in expression of TLR pathway associated genes to Porphyromonas gingivalis. J Perio Res. 2014 May 24. doi:10.1111/jre.12185. Abstract / Full Text

Yu C, Lopez CA, Hu H, Xia Y, Freedman DS, Reddington AP, Daaboul GG, Unlü MS, Genco CA. A high-throughput method to examine protein-nucleotide interactions identifies targets of the bacterial transcriptional regulatory protein fur.PLoS One. 2014 May 8;9(5):e96832. Abstract / Full Text

Beaulieu LM, Lin E, Mick E, Koupenova M, Weinberg EO, Kramer CD, Genco CA, Tanriverdi K, Larson MG, Benjamin EJ, Freedman JE. Interleukin 1 receptor 1 and interleukin 1β regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans. Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):552-64. Abstract / Full Text

Genco CA, Barth K, Gudino CV, Kramer C, Slocum C, Weinberg, E, Smith J, Ingalls R, Freedman J, Ingalls R, Freedman J, Gibson F, Beaulieu L, Wetzler L, Hamilton J, shaik-Dasthagirlsaheb Y, He X, Xiuping L (Group Members). A Dangerous Response: Targeting Chronic Inflammation. 2013. International Innovation–International Innovation, published by Research Media, is the leading global dissemination resource for the wider scientific, technology and research communities, dedicated to disseminating the latest science, research and technological innovations on a global level. More information and a complimentary subscription offer to the publication can be found at: www.researchmedia.eu. Full PDF

Daou N, Yu C, McClure R, Gudino C, Reed GW, Genco CA. Neisseria Prophage Repressor Implicated in Gonococcal Pathogenesis. Infect Immun. 2013 Oct;81(10):3652-61. Abstract / Full Text

Miles B, Scisci E, Carrion J, Sabino GJ, Genco CA, Cutler CW. Noncanonical dendritic cell differentiation and survival driven by a bacteremic pathogen. J Leukoc Biol. 2013 Aug;94(2):281-9. Abstract / Full Text

McClure R, Balasubramanian D, Sun Y, Bobrovskyy M, Sumby P, Genco CA, Vanderpool CK, Tjaden B. Computational analysis of bacterial RNA-Seq data. Nucleic Acids Res. 2013 Aug 1;41(14):e140. Abstract / Full Text

Papadopoulos G, Weinberg EO, Massari P, Gibson FC 3rd, Wetzler LM, Morgan EF, Genco CA. Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss. J Immunol. 2013 Feb 1;190(3):1148-57. Abstract / Full Text

Barth K, Remick DG, Genco CA. Disruption of immune regulation by microbial pathogens and resulting chronic inflammation. J Cell Physiol. 2013 Jul;228(7):1413-22. Abstract / Full Text

Weinberg EO, Genco CA. Directing TRAF-ic: cell-specific TRAF6 signaling in chronic inflammation and atherosclerosis. Circulation. 2012 Oct 2;126(14):1678-80. Abstract / Full Text

Hayashi C, Papadopoulos G, Gudino CV, Weinberg EO, Barth KR, Madrigal AG, Chen Y, Ning H, LaValley M, Gibson FC 3rd, Hamilton JA, Genco CA. Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen. J Immunol. 2012 Oct 1;189(7):3681-8. Abstract / Full Text

Madrigal AG, Barth K, Papadopoulos G, Genco CA. Pathogen-mediated proteolysis of the cell death regulator RIPK1 and the host defense modulator RIPK2 in human aortic endothelial cells. PLoS Pathog. 2012;8(6):e1002723. doi: 10.1371/journal.ppat.1002723. Epub 2012 Jun 7. Abstract / Full Text

Lopez, C.A., G.G. Daaboul, S.  Ahn, A. P. Reddington, M.R. Monroe, X.  Zhang, R.J. Irani, C. Yu, C. A. Genco, M. Cretich, M. Chiari, B. B. Goldberg, J. H. Connor, and M. Selim Ünlü. Biomolecular detection employing the Interferometric Reflectance Imaging Sensor (IRIS).  JoVE Bioengineering.
 J Vis Exp. (51): 2694, 2011. Abstract / Full Text

Hayashi, C., J. Viereck, N. Hua, A.G. Madrigal, F.C. Gibson, J.A. Hamilton, and C.A. Genco. Porphyromonas gingivalis accelerates inflammatory atherosclerosis in the innominate artery of ApoE deficient mice. Atherosclerosis. 215: 52-59, 2011. Abstract / Full Text

Hayashi, C., Gudino, C.V., Gibson, F. C. III, C. A. Genco. Pathogen-Induced Inflammation at Sites Distant from Oral Infection: Bacterial Persistence and Induction of Cell Specific Innate Immune Inflammatory Pathways. Review. Mol Oral Microbiol. 25 (5) 305-16, 2010. Abstract / Full Text

Mellin JR, McClure R, Lopez D, Green O, Genco CA. Role of Hfq in iron dependent and independent gene regulation Neisseria meningitidis. Microbiology.  156:  2316-2326, 2010. Abstract / Full Text

Hayashi, C., Madrigal, A. G., Liu, X., Ukai, T., Goswami, S., Gudino, C. V., Gibson, F. C. III, and C. A. Genco. Pathogen Mediated Inflammatory Atherosclerosis is Mediated in Part via TLR2 Induced Inflammatory Responses. J Innate Immun. 2:334-43, 2010. AbstractFull Text

Genco C, Wetzler L. Neisseria: Molecular Mechanisms of Pathogenesis. 2009. January 2010. Caister Academic Press. How to Order

Follows SA, Murlidharan J, Massari P, Wetzler LM, Genco CA. Neisseria gonorrhoeae Infection Protects Human Endocervical Epithelial from Apoptosis via Expression of Host Anti-Apoptotic Proteins. Infect. Immun. 77: 3602-3610, 2009. Abstract / Full Text

Blair P, Rex S, Vitseva O, Beaulieu L, Tanriverdi K, Chakrabarti S, Hayashi C, Genco CA, Iafrati M, Freedman JE. Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase. Cir. Res. 104: 346-354, 2009. Abstract / Full Text

Agarwal S, Sebastian S, Szmigielski B, Rice PA, Genco CA. Expression of the gonococcal global regulatory protein Fur and genes encompassing the Fur and iron regulon during in vitro and in vivo infection in women. J. Bacteriol.  190:3129-3139, 2008. Abstract / Full Text

Isabella, V., L. F. Wright, K. Barth, J.M. Spence, S. Grogan, C.A.  Genco, and V.L.  Clark. cis- and trans-acting elements involved in regulation of norB (norZ), the gene encoding nitric oxide reductase in Neisseria gonorrhoeae.  Microbiology 154: 226-239, 2008.

Davey M, Liu X, Ukai T, Jain V, Gudino C, Gibson FC 3rd, Golenbock D, Visintin A, Genco CA. Bacterial fimbriae stimulate proinflammatory activation in the endothelium through distinct TLRs. J Immunol. 2008 Feb 15;180(4):2187-95. Abstract / Full Text

Ukai T, Yumoto H, Gibson FC 3rd, Genco CA. Macrophage-elicited osteoclastogenesis in response to bacterial stimulation requires Toll-like receptor 2-dependent tumor necrosis factor-alpha production. Infect Immun. 2008 Feb;76(2):812-9. Abstract / Full Text

Gibson FC 3rd, Ukai T, Genco CA. Engagement of specific innate immune signaling pathways during Porphyromonas gingivalis induced chronic inflammation and atherosclerosis. Front Biosci. 2008 Jan 1;13:2041-59. Review. Abstract

Liu X, Ukai T, Yumoto H, Davey M, Goswami S, Gibson FC 3rd, Genco CA. Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids. Atherosclerosis. 2008 Jan;196(1):146-54. Epub 2007 Apr 26. Abstract

Mellin JR, Goswami S, Grogan S, Tjaden B, Genco CA. A novel fur- and iron-regulated small RNA, NrrF, is required for indirect fur-mediated regulation of the sdhA and sdhC genes in Neisseria meningitidis. J Bacteriol. 2007 May;189(10):3686-94. Epub 2007 Mar 9. Abstract / Full Text

Gibson FC 3rd, Genco CA. Porphyromonas gingivalis mediated periodontal disease and atherosclerosis: disparate diseases with commonalities in pathogenesis through TLRs. Curr Pharm Des. 2007;13(36):3665-75. Review. Abstract

Shaik YB, Grogan S, Davey M, Sebastian S, Goswami S, Szmigielski B, Genco CA. Expression of the iron-activated nspA and secY genes in Neisseria meningitidis group B by Fur-dependent and -independent mechanisms. J Bacteriol. 2007 Jan;189(2):663-9. Epub 2006 Nov 3. Abstract / Full Text

Takahashi Y, Davey M, Yumoto H, Gibson FC 3rd, Genco CA. Fimbria-dependent activation of pro-inflammatory molecules in Porphyromonas gingivalis infected human aortic endothelial cells. Cell Microbiol. 2006 May;8(5):738-57. Abstract

Miyamoto T, Yumoto H, Takahashi Y, Davey M, Gibson FC 3rd, Genco CA. Pathogen-accelerated atherosclerosis occurs early after exposure and can be prevented via immunization. Infect Immun. 2006 Feb;74(2):1376-80. Abstract / Full Text

Takahashi, Y. ,  M. Davey, Yumoto, H., F.C. Gibson, and C.A. Genco. Fimbria-dependent activation of pro-inflammatory molecules in Porphyromonas gingivalis infected human aortic endothelial cells. Cellular Microbiol. 8: 738-757, 2006

Liu, X, T. Olczak, H.C. Guo, D.W. Dixon, and C. A Genco. Identification of amino acid residues involved in heme binding and hemoprotein utilization in the Porphyromonas gingivalis heme receptor HmuR.  Infect.  Immun.  74: 1222-1232, 2006.

Bartolini, E., E. Frigimelica, Y. Shaik, G. Galli, J.A. Welsch, D.M. Granoff, C.A. Genco, G. Grandi, and R. Grifantini. Role of FNR and FNR-regulated, sugar fermentation genes in Neisseria meningitidis infection. Mol. Microbiol. 60: 963-972, 2006.

Mydel, P., Y. Takahashi, H. Yumoto, M. Sztukowska, M. Kubica, F.C. Gibson, D.   Kurtz, J. Travis, C.A. Genco, and J. Potempa. Role of the host oxidative immune response and the bacterial antioxidant, rubrerythrin during anaerobic infection.  Plos Pathogens. 2:712-725, 2006.

Al-Qutub, M.N, Braham, P.H., Karimi-Naser, K., Liu, X, Genco, C.A. and R.P. Darveau. Hemin-dependent modulation of the lipidA structure of Porphyromonas gingivalis lipopolysaccharide.  Infect. Immun.  74: 4474-4485, 2006.

*Listed are selected publications generated from the Genco laboratory or through interactions with collaborating laboratories. For a complete list of publications click here and search Caroline Genco.

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July 22, 2014
Primary teaching affiliate
of BU School of Medicine