Samta Jain Ph.D.

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Samta Jain

Postdoctoral Associate

Address: Boston University Department of Medicine, Section of Infectious Diseases. 650 Albany st. X-620. Boston, MA 02118

Email: samtajk@bu.edu

Office: 617-414-5256

 

 

 

Education:

Post-doctorate (2011-2013), Department of Molecular Microbiology, University of Groningen, The Netherlands

Research area: Ether-lipid membrane engineering of Escherichia coli

Post-doctorate (2010-2011), Department of Ecophysiology, Max-Planck-Institute for Terrestrial Microbiology, Marburg, Germany

Research area: Biochemical investigation of the outer membrane secretin complex of the Type IV pili system of pathogenic Neisseria.

Ph.D. (2005- 2010), Department of Molecular Microbiology, University of Groningen, The Netherlands

Research area: The type IV secretion and the type IV pili systems of Neisseria gonorrhoeae

MSc (Master of Science), Biotechnology, AMC- Bangalore University, India

 

Research:

Host-pathogen interaction- Porphyromonas gingivalis mediated infection of the host cell

Porphyromonas gingivalis is an anaerobic gram-negative bacterium and a major causative factor for periodontal disease in humans. The cysteine proteases of P. gingivalis called gingipains function in bacterial survival, colonization and evasion of the host defenses. Although gingipains can cleave numerous substrates within the host cell, the exact functional consequence of this activity is not well understood. I am studying the mechanisms by which P. gingivalis and these secreted virulence factors enter the host cells and investigating their role in evasion of the intracellular innate immune signaling.

 

Publications:

Siewering K*, Jain S*, Friedrich C, Webber-Birungi M T, Alexander Wagner I, Huntley S, Kahnt J, Klingl A, Boekema E J, Søgaard-Andersen L, and van der Does C. Peptidoglycan-binding protein TsaP functions in surface assembly of type IV pili. 2014, PNAS 111(10): E953–61.Abstract / Full Text.

Jain S*, Zweig M*, Peeters E, Siewering K, Hackett KT, Dillard J P and van der Does C. Characterization of the Single Stranded DNA Binding Protein SsbB Encoded in the Gonoccocal Genetic Island.2012, PLoS One 7(4):e35285. Full Text.

Jain S, Kahnt J and van der Does C. Processing and Maturation of the pilin of the type IV secretion system encoded within the gonococcal genetic island. 2011, J Biol Chem. 286(51):43601-10. Full Text.

Jain S*, Moscicka K B*, Bos M P, Pachulec E, Stuart M C, Keegstra W, Boekema E J and van der Does C. Structural characterization of outer membrane components of the type IV pili system in pathogenic Neisseria. 2011, PLoS One 6: e16624. Full Text.

Salgado-Pabon W, Jain S, Turner N, van der Does C and Dillard J P. A novel relaxase homologue is involved in chromosomal DNA processing for type IV secretion in Neisseria gonorrhoeae. 2007, Mol Microbiol 66: 930-947. Abstract.

Jain S, Rajput A, Kumar Y, Uppuluri N, Arvind A S and Tatu U. Proteomic analysis of urinary protein markers for accurate prediction of diabetic kidney disorder. 2005, J Assoc Physicians India 53: 513-520. Abstract.

Khachane A, Kumar R, Jain S, Jain S, Banumathy G, Singh V, Nagpal S and Tatu U.“Plasmo2D”: an ancillary proteomic tool to aid identification of proteins from Plasmodium falciparum. 2005 J Proteome Res 4: 2369-2374. Abstract.

 

*These authors contributed equally.

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July 22, 2014
Primary teaching affiliate
of BU School of Medicine