Ryan McClure B.S.
PHD-Candidate in Microbiology
Address: Boston University Department of Medicine, Section of Infectious Diseases. 650 Albany st X-620. Boston, MA 02118
I am originally from Adrian, Michigan. I attended Michigan State University and obtained a B.S. in Biochemistry there. After moving out to Boston after graduating I worked at the Center for Human Genetics at Boston University Medical Center. There I analyzed chromosomes and performed karyotypes on infertile couples or patients with cancer. After taking one or two classes at Boston University I decided to pursue my PhD in Microbiology.
Ph.D. Candidate in Microbiology, Boston University Department of Medicine; Boston, MA
B.S. in Biochemistry, Michigan State University; Michigan
Neisseria meningitidis is a Gram-negative bacteria that is the one of the causative agents of meningitis. Proper regulation of gene expression is crucial to growth of the bacteria both in culture and in a host. One way in which bacteria control gene expression is through small RNAs. Small RNAs bind to messenger RNA molecules and prevent their translation into protein. Recently our lab has identified the first small RNA in N. meningitidis, Nrrf. Nrrf binds to the succinate dehydrogenase genes and prevents their translation into proteins. Most small RNAs function using a protein called Hfq as a required cofactor (although surprisingly Nrrf seems to be Hfq independent). Our lab also has microarray data from a mutant strain of N. meningitidis which has no functional Hfq. Genes which show differential expression based on the absence or presence of Hfq are probable targets of small RNA regulation. Currently, I am working to find other small RNAs and their messenger RNA targets in N. meningitidis.
Mellin JR, Lopez D, McClure R, and Genco CA.
Hfq is Not Required For Action of the Fur-regulated sRNA NrrF but Significantly Affects Additional Aspects of Gene Regulation In Neisseria meningitidis. 2009. Infect Immun. [Submitted for publication].
Huang XL, Isabel de Michelena M, Leon E, Maher TA, McClure R, and Milunsky A.
Pallister-Killian syndrome: tetrasomy of 12pter–>12p11.22 in a boy with an analphoid, inverted duplicated marker chromosome. Nov 2007. Clin Genet 72:72(5):434.