Cynthia V. Gudino M.P.H.

 

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Cynthia Gudino

Laboratory Research Manager

Address: Boston University Department of Medicine, Section of Infectious Diseases. 650 Albany st X-620. Boston, MA 02118

Email: gudino@bu.edu

Office: 617-414-5299

Fax: 617-414-5298

 

 

 

About Me:

I am originally from California. I have been in Boston since 2003 studying and working at Boston University.Currently I am interested in pursuing a career in Public Health as it relates to infectious diseases, biosafety, and prevention.  I have worked in the Genco laboratory since 2007. I was an undergraduate intern, under the supervision of Takashi Ukai and Xinyan (Lucy) Liu, in the Genco lab for one year prior to my position. I have high hopes, dreams and enthusiasm for what I do and what I wish to do in the future and am grateful for my experiences in the lab.

Research:

The innate immune system is our body’s first line of defense against foreign organisms. It recognizes, recruits and destroys invading bacteria. My research looks at activation of cells of the innate immune system, through cytokine and chemokine production, by the periodontal pathogen Porphyromonas gingivalis. Recently research has shown an association between P.gingivalis and the risk for cardiovascular disease. P.gingivalis causes a chronic inflammatory disorder through the Toll-like receptor pathway. I look at P.gingivalis infection in knockdown mouse models (TLRs, IL-1b, IL-1) and cell lines analyzing the host-response to infection–atherosclerosis, inflammation, and pathogenesis.

Another project I am currently working on is the effects of Neisseria gonorrhoeae (GC) infection and the role of intracellular receptors (NOD1, NOD2, Rip2, and cIAP2), identified as key mediators of inflammatory and immune responses, in knockdown mouse models. I am currently working on establishing the GC infection mouse model in our laboratory. Looking at GC colonization, PMN influx and cytokine/chemokine production in our knockout models.

In addition to my research I am also the Laboratory Manager and Laboratory Safety Coordinator in the Genco lab. I keep our lab organized, supervise work, and maintain a safe environment for our growing lab. I am interested in advancing biosafety and establishing a safe and efficient environment for laboratories to conduct research. If you have any questions about our lab, my project, or safety feel free to contact me.

Education:

M.P.H. in Environmental Health, Boston University School of Public Health

B.A. in Biology, Boston University College of Arts and Sciences

Publications:

Papadopoulos, G., Kramer, C., Slocum, C., Weinberg, E., Hua, N., Gudino, C.V., Hamilton, J.A., C.A. Genco.  A Mouse Model for Pathogen-Induced Chronic Inflammation at Local and Systemic Sites. Journal of Visualized Experiments (JoVE). 2014. In Press.

Slocum CS, Coats R, Hua N, Kramer C, Papadopolous G, Weinberg EO, Gudino CV, Hamilton JA, Darveau RP, Genco CA. Distinct lipid A moieties contribute to pathogen-induced site-specific vascular inflammation. PLoS pathogens. 2014 July 2014; 10(7): e1004215. Full Text

Genco CA, Barth K, Gudino CV, Kramer C, Slocum C, Weinberg, E, Smith J, Ingalls R, Freedman J, Ingalls R, Freedman J, Gibson F, Beaulieu L, Wetzler L, Hamilton J, shaik-Dasthagirlsaheb Y, He X, Xiuping L (Group Members). A Dangerous Response: Targeting Chronic Inflammation. 2013. International Innovation.

Daou N, Yu C, McClure R, Gudino C, Reed GW, Genco CA. Neisseria Prophage Repressor Implicated in Gonococcal Pathogenesis. Infect Immun. 2013 Oct;81(10):3652-61. Abstract / Full Text

Hayashi C, Papadopoulos G, Gudino CV, Weinberg EO, Barth KR, Madrigal AG, Chen Y, Ning H, LaValley M, Gibson FC 3rd, Hamilton JA, Genco CA. Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen. J Immunol. 2012 Oct 1;189(7):3681-8. Abstract / Full Text

Hayashi, C., Gudino, C.V., Gibson, F. C. III, C. A. Genco. Pathogen-Induced Inflammation at Sites Distant from Oral Infection: Bacterial Persistence and Induction of Cell Specific Innate Immune Inflammatory Pathways. Review. Mol Oral Microbiol. 25 (5) 305-16, 2010. Abstract / Full Text

Hayashi, C., Madrigal, A. G., Liu, X., Ukai, T., Goswami, S., Gudino, C. V., Gibson, F. C. III, and C. A. Genco. Pathogen Mediated Inflammatory Atherosclerosis is Mediated in Part via TLR2 Induced Inflammatory Responses. J Innate Immun. 2:334-43, 2010. Abstract / Full Text

Davey M, Liu X, Ukai T, Jain V, Gudino C, Gibson FC 3rd, Golenbock D, Visintin A, Genco CA. Bacterial fimbriae stimulate proinflammatory activation in the endothelium through distinct TLRs. J Immunol. 2008 Feb 15;180(4):2187-95. Abstract / Full Text

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July 22, 2014
Primary teaching affiliate
of BU School of Medicine